egg-white and Eczema

Food atopy is important but inadequately studied among children with atopic dermatitis (AD). We evaluated whether any association existed between AD severity, quality of life, total IgE, eosinophil counts, and the number of food items sensitized. Specific IgE of ten common food items was measured for a group of consecutive AD patients (n=85) enrolled during a randomized trial and correlated the findings with eczema severity. Twenty-four patients (28%) were negative for any of the ten common food items. The most commonly sensitized foods were shrimp (54%), egg white (43%), wheat (42%), and peanut (41%). Atopy to beef as a protein and orange as a fruit were least common among the food items studied, even among patients positive for 8-9 IgE items. Patients with severe AD (objective SCORAD>40) were more likely to be positive for at least one of the food items (Yates corrected p=0.024 for ≥1 food-specific IgE in severe vs. moderate AD, OR 3.42 and 95% CI 1.15-10.32); and for at least seven of the food items (p=0.001 for ≥7 food-specific IgE vs. nil with OR 11.67 and 95% CI 2.29-67.77), respectively. The Spearman coefficients between the number of positive food-specific IgE and total SCORAD, objective SCORAD, area of AD involvement, Children's Dermatology Life Quality Index (CDLQI), total IgE levels, and eosinophil counts were 0.42 (p<0.001), 0.45 (p<0.001), 0.50 (p<0.001), 0.17 (p=0.116), 0.80 (p<0.001), and 0.22 (p=0.043), respectively. Specific IgE levels for beef correlated with all the other food-specific IgE levels, including cow's milk (ρ=0.061, p<0.001) and soy (ρ=0.70, p<0.001). The number of common food items sensitized correlated with disease severity, extent, and total IgE levels. IgE sensitization to beef protein is unlikely in the majority of children with AD, but its serum IgE level is associated with disease severity and risk of sensitization to other foods.

Topics: Adolescent; Allergens; Animals; Antibody Specificity; Arachis; Cattle; Child; Dermatitis, Atopic; Eczema; Egg White; Eosinophils; Female; Food Hypersensitivity; Humans; Immunoglobulin E; Leukocyte Count; Male; Meat; Quality of Life; Severity of Illness Index

Eighty-two children with food sensitivity were followed-up for 2-5 years. Most children showed a decreasing sensitivity and the clinical course of food allergy seemed to reflect the course of the humoral immune responses to the offending foods. The occurrence of IgE- and IgG-antibodies paralleled in most cases. However, an early, high IgG/IgE food antibody ratio seemed to be a good prognostic sign, indicating a possible blocking capacity of IgG-antibodies.

Topics: Adolescent; Animals; Asthma; Cattle; Child; Child, Preschool; Conjunctivitis; Eczema; Egg White; Fishes; Follow-Up Studies; Food Hypersensitivity; Humans; Immune Tolerance; Immunoglobulin E; Immunoglobulin G; Immunoglobulins; Lactoglobulins; Milk; Ovomucin; Rhinitis

Prick tests to milk and egg white were compared to clinical histories of sensitivity to these foods. Seventeen RAST-positive versus 17 RAST-negative controls were used. All 34 children and young adults were selected because they had atopic respiratory and/or dermal manifestations. Atopic eczema manifestations were present in 11 of the RAST-postive subjects and in two of the controls. Of these, nine had past history of egg white intolerance. Egg white challenge was associated with dermal reactions as follows: eczema in two, urticaria in two and angioedema in two. Positive clinical histories compared favorably (p less than 0.001) with prick tests for egg white but poorly (p greater than 0.05) for milk. Similarly, positive clinical histories compared significantly (p less than 0.001) with RAST for egg white but poorly (p greater than 0.05) for milk.

Topics: Adolescent; Adult; Allergens; Animals; Asthma; Cattle; Child; Eczema; Egg White; Female; Humans; Hypersensitivity; Immunoglobulin E; Male; Medical History Taking; Milk; Radioallergosorbent Test; Rhinitis, Allergic, Seasonal; Skin Tests; Time Factors

The diagnostic reliability in food allergy of skin prick tests (SPT) and the radio-allergosorbent test (RAST) was investigated in paediatric patients with respiratory and skin allergies. SPT and RAST were found to be reliable for the diagnosis of allergy to codfish, peas, nuts, peanuts and egg white. Positive SPT and RAST to cereals were common, but were most often without clinical significance or were correlated with respiratory allergy to the inhalation of flour dust. SPT and RAST were only partly reliable with regard to allergy to cow's milk, and were mostly reliable when used together and showing corresponding results. Experimental allergosorbents for RAST with soy beans and white beans were not reliable. The study shows the need to improve the diagnostic materials and to establish the diagnostic reliability of the material and tests used for each food item in question.

Topics: Adolescent; Animals; Arachis; Asthma; Child; Child, Preschool; Eczema; Edible Grain; Egg White; Fabaceae; Food Hypersensitivity; Humans; Infant; Milk; Nuts; Plants, Medicinal; Radioallergosorbent Test; Skin Tests

Topics: Allergens; Animals; Antibodies; Asthma; Cats; Child; Child, Preschool; Dogs; Dust; Eczema; Egg White; Female; Fishes; Follow-Up Studies; Horses; Humans; Immunoglobulin E; Infant; Male; Milk; Pollen; Radioimmunoassay; Rhinitis, Allergic, Seasonal; Skin Tests; Urticaria

Topics: Adult; Albumins; Amniotic Fluid; Antibodies; Breast Feeding; Eczema; Egg White; Female; Food Hypersensitivity; Glycine max; Hemagglutination Tests; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Pregnancy

Topics: Adult; Allergens; Animals; Breast Feeding; Eczema; Egg White; Female; Food Hypersensitivity; Glycine max; Hemagglutination Tests; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Milk