egg-white and Celiac-Disease

Undernourishment is common in children with cerebral palsy (CP), but the reasons are unknown. We previously reported elevated levels of immunoglobulin (Ig) A and IgG antibodies against gliadin (AGA) and tissue transglutaminase (tTG) in 99 children and young adults with CP without characteristic findings of gluten enteropathy in small bowel biopsies. Our aim was to perform a case-control study of IgG antibodies against other dietary antigens, AGA, anti-tTG, and IgE antibodies against wheat and gluten.. Sera from 99 cases with CP and 99 healthy, age- and sex-matched controls were analysed with fluorescence enzyme-linked immunosorbent assay for detection of IgG antibodies against β-lactoglobulin, casein, egg white, IgG- and IgA-AGA, IgA-anti-tTG, and IgE antibodies against gluten and wheat.. Compared with controls, the odds ratio in cases with CP for having elevated levels of IgG antibodies against β-lactoglobulin was 17.0 (95% confidence interval [CI] 2.3-128), against casein 11.0 (95% CI 2.6-46.8), and against egg white 7.0 (95% CI 1.6-30.8). The IgE responses for wheat/gluten were generally low. The tetraplegic and dyskinetic CP subtypes had significantly higher frequencies of elevated levels for all of the tested antibodies except IgG against egg white, and IgA-anti-tTG. A significantly lower weight was seen in cases with CP with positive versus negative serology.. Elevated levels of IgG against dietary antigens were more frequent in the CP group compared with controls, and particularly in the tetraplegic and dyskinetic CP subtypes with the most severe neurologic handicap and undernourishment. Hypothetically, malnourishment may cause increased intestinal permeability and thus immunization against dietary antigens.

Topics: Adolescent; Adult; Antibodies; Autoantibodies; Body Weight; Case-Control Studies; Caseins; Celiac Disease; Cerebral Palsy; Child; Child, Preschool; Dietary Proteins; Egg White; Female; Glutens; Humans; Immunoglobulin A; Immunoglobulin E; Immunoglobulin G; Infant; Lactoglobulins; Male; Malnutrition; Transglutaminases; Triticum; Young Adult

Celiac disease, eosinophilic esophagitis, and urticaria are 3 manifestations of food allergy with different pathogenic mechanisms. We report the case of a 2-year-old child with digestive symptoms, slow growth, and severe asthma. The results of skin prick tests were positive to several foods. Endoscopy revealed eosinophilic esophagitis and celiac disease. Treatment consisted of a gluten-free diet and a 1-month course of oral corticosteroids. Endoscopy and biopsy findings were normal at 5 years of age. A gluten-free diet is the basis of treatment of celiac disease, but the role of an elimination diet in eosinophilic esophagitis is not well established. Our patient also developed urticaria when exposed to milk and egg.We present, to our knowledge, the first report of a patient with celiac disease, eosinophilic esophagitis, and immediate-type immunoglobulin E-mediated food allergy.

Topics: Animals; Celiac Disease; Child, Preschool; Diet, Gluten-Free; Egg White; Eosinophilic Esophagitis; Female; Food Hypersensitivity; Glutens; Humans; Immunoglobulin E; Milk; Treatment Outcome; Urticaria

Topics: Animals; Antigens; CD4-Positive T-Lymphocytes; Celiac Disease; Chick Embryo; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Egg White; Humans; Indomethacin; Mice; Mice, Inbred Strains; Mice, Transgenic; Muramidase; Receptors, Antigen, T-Cell

By means of the leukocyte migration inhibition test a significant depression of migration index (indicating increased immunity) was found in 10 untreated coeliac patients compared with 24 control subjects with the dietary antigens bovine serum albumin (BSA) and egg white but not with milk. The degree of immunity was similar to that obtained with gluten fraction III as antigen. Treatment with a gluten-free diet led to a decrease in immunity to egg white and BSA, but immunity to gluten fraction III was increased in the early months of treatment.

Topics: Adolescent; Adult; Animals; Antigens; Cattle; Celiac Disease; Child; Egg White; Female; Glutens; Humans; Immunity, Cellular; Leukocyte Migration-Inhibitory Factors; Male; Middle Aged; Milk; Serum Albumin, Bovine

Topics: Adult; Aged; Animals; Antibodies; Celiac Disease; Egg White; Female; Food Hypersensitivity; Glutens; Humans; Male; Middle Aged; Milk; Mood Disorders; Schizophrenia

Topics: Animals; Antibodies; Blood; Celiac Disease; Child, Preschool; Edible Grain; Egg White; Egg Yolk; Female; Folic Acid; Food Hypersensitivity; Glutens; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulins; Male; Milk; Oryza; Sheep; Triticum