eflornithine has been researched along with Vomiting in 3 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Vomiting: The forcible expulsion of the contents of the STOMACH through the MOUTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Subacute (2 week) oral or intravenous administration of DL-alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), caused diarrhea and frequent emesis as early as 4 to 5 days in dogs (dose greater than or equal to 200 mg/kg/day)." | 3.66 | Intestinal changes caused by DL-alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase. ( Diekema, KA; Gibson, JP; Loudy, DE; McCann, PP; Sprinkle, DJ; Yarrington, JT, 1983) |
| "Patients with resected superficial bladder cancers were studied." | 2.68 | Toxicity evaluation of difluoromethylornithine: doses for chemoprevention trials. ( Loprinzi, CL; Love, RR; Messing, EM; Morton, RF; Novotny, P; O'Fallon, JR; Poon, MA; Quella, SK; Trump, DL, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yarrington, JT | 1 |
| Sprinkle, DJ | 1 |
| Loudy, DE | 1 |
| Diekema, KA | 1 |
| McCann, PP | 1 |
| Gibson, JP | 1 |
| Loprinzi, CL | 1 |
| Messing, EM | 1 |
| O'Fallon, JR | 1 |
| Poon, MA | 1 |
| Love, RR | 1 |
| Quella, SK | 1 |
| Trump, DL | 1 |
| Morton, RF | 1 |
| Novotny, P | 1 |
| Levin, VA | 1 |
| Chamberlain, MC | 1 |
| Prados, MD | 1 |
| Choucair, AK | 1 |
| Berger, MS | 1 |
| Silver, P | 1 |
| Seager, M | 1 |
| Gutin, PH | 1 |
| Davis, RL | 1 |
| Wilson, CB | 1 |
1 trial available for eflornithine and Vomiting
| Article | Year |
|---|---|
Toxicity evaluation of difluoromethylornithine: doses for chemoprevention trials.
Topics: Antineoplastic Agents; Carcinoma, Transitional Cell; Chemoprevention; Dose-Response Relationship, Dr | 1996 |
2 other studies available for eflornithine and Vomiting
| Article | Year |
|---|---|
Intestinal changes caused by DL-alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase.
Topics: Animals; Depression, Chemical; Diarrhea; Dogs; Eflornithine; Female; Intestinal Absorption; Intestin | 1983 |
Phase I-II study of eflornithine and mitoguazone combined in the treatment of recurrent primary brain tumors.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Drug Eval | 1987 |