Page last updated: 2024-10-25

eflornithine and Vomiting

eflornithine has been researched along with Vomiting in 3 studies

Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.

Vomiting: The forcible expulsion of the contents of the STOMACH through the MOUTH.

Research Excerpts

ExcerptRelevanceReference
"Subacute (2 week) oral or intravenous administration of DL-alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), caused diarrhea and frequent emesis as early as 4 to 5 days in dogs (dose greater than or equal to 200 mg/kg/day)."3.66Intestinal changes caused by DL-alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase. ( Diekema, KA; Gibson, JP; Loudy, DE; McCann, PP; Sprinkle, DJ; Yarrington, JT, 1983)
"Patients with resected superficial bladder cancers were studied."2.68Toxicity evaluation of difluoromethylornithine: doses for chemoprevention trials. ( Loprinzi, CL; Love, RR; Messing, EM; Morton, RF; Novotny, P; O'Fallon, JR; Poon, MA; Quella, SK; Trump, DL, 1996)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19902 (66.67)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yarrington, JT1
Sprinkle, DJ1
Loudy, DE1
Diekema, KA1
McCann, PP1
Gibson, JP1
Loprinzi, CL1
Messing, EM1
O'Fallon, JR1
Poon, MA1
Love, RR1
Quella, SK1
Trump, DL1
Morton, RF1
Novotny, P1
Levin, VA1
Chamberlain, MC1
Prados, MD1
Choucair, AK1
Berger, MS1
Silver, P1
Seager, M1
Gutin, PH1
Davis, RL1
Wilson, CB1

Trials

1 trial available for eflornithine and Vomiting

ArticleYear
Toxicity evaluation of difluoromethylornithine: doses for chemoprevention trials.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1996, Volume: 5, Issue:5

    Topics: Antineoplastic Agents; Carcinoma, Transitional Cell; Chemoprevention; Dose-Response Relationship, Dr

1996

Other Studies

2 other studies available for eflornithine and Vomiting

ArticleYear
Intestinal changes caused by DL-alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase.
    Experimental and molecular pathology, 1983, Volume: 39, Issue:3

    Topics: Animals; Depression, Chemical; Diarrhea; Dogs; Eflornithine; Female; Intestinal Absorption; Intestin

1983
Phase I-II study of eflornithine and mitoguazone combined in the treatment of recurrent primary brain tumors.
    Cancer treatment reports, 1987, Volume: 71, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Drug Eval

1987