eflornithine has been researched along with Tuberous Sclerosis in 1 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Tuberous Sclerosis: Autosomal dominant neurocutaneous syndrome classically characterized by MENTAL RETARDATION; EPILEPSY; and skin lesions (e.g., adenoma sebaceum and hypomelanotic macules). There is, however, considerable heterogeneity in the neurologic manifestations. It is also associated with cortical tuber and HAMARTOMAS formation throughout the body, especially the heart, kidneys, and eyes. Mutations in two loci TSC1 and TSC2 that encode hamartin and tuberin, respectively, are associated with the disease.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McKenna, J | 1 |
| Kapfhamer, D | 1 |
| Kinchen, JM | 1 |
| Wasek, B | 1 |
| Dunworth, M | 1 |
| Murray-Stewart, T | 1 |
| Bottiglieri, T | 1 |
| Casero, RA | 1 |
| Gambello, MJ | 1 |
1 other study available for eflornithine and Tuberous Sclerosis
| Article | Year |
|---|---|
Metabolomic studies identify changes in transmethylation and polyamine metabolism in a brain-specific mouse model of tuberous sclerosis complex.
Topics: Animals; Brain; Cystathionine; Cystathionine beta-Synthase; Disease Models, Animal; DNA Methylation; | 2018 |