eflornithine has been researched along with Seizures in 9 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The running was followed by seizures and sometimes death." | 5.29 | Inhibition of DFMO-induced audiogenic seizures by chlordiazepoxide. ( Fuller, DJ; Gensler, HL; Gerner, EW; Gerrish, KE, 1993) |
| " Patients aged 15 years or older with confirmed second-stage T b gambiense infection were randomly assigned by computer-generated randomisation sequence to receive intravenous eflornithine (400 mg/kg per day, every 6 h; n=144) for 14 days or intravenous eflornithine (400 mg/kg per day, every 12 h) for 7 days with oral nifurtimox (15 mg/kg per day, every 8 h) for 10 days (NECT; n=143)." | 5.14 | Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial. ( Arnold, U; Baudin, E; Buard, V; Ghabri, S; Ghorashian, S; Ilunga, M; Kande, V; Karunakara, U; Kasparian, S; Kazadi-Kyanza, S; Mutangala, W; Mutombo, W; Ngouama, D; Pohlig, G; Priotto, G; Schmid, C; Torreele, E, 2009) |
| " This open trial shows that DFMO is as active as and possibly less toxic than melarsoprol." | 2.67 | Efficacy and toxicity of eflornithine for treatment of Trypanosoma brucei gambiense sleeping sickness. ( Ethier, L; Loko, L; Milord, F; Mpia, B; Pépin, J, 1992) |
| "The running was followed by seizures and sometimes death." | 1.29 | Inhibition of DFMO-induced audiogenic seizures by chlordiazepoxide. ( Fuller, DJ; Gensler, HL; Gerner, EW; Gerrish, KE, 1993) |
| "Experimental seizures are followed by an especially rapid and massive induction of brain ornithine decarboxylase (ODC), an enzyme which catalyses the rate-limiting step in the synthesis of polyamines." | 1.28 | Ornithine decarboxylase induction and polyamine synthesis in the kindling of seizures: the effect of alpha-difluoromethylornithine. ( de Belleroche, JS; Herberg, LJ; Mintz, M; Rose, IC, 1992) |
| "Kainate-induced seizure activity was followed by a transient increase in ODC activity, a long-lasting increase in putrescine levels and spectrin degradation, and a delayed increase in 3H-Ro5-4864 binding, mainly in hippocampus and piriform cortex." | 1.28 | Changes in polyamine levels and spectrin degradation following kainate-induced seizure activity: effect of difluoromethylornithine. ( Baudry, M; el-Skaf, G; Lynch, G; Massicotte, G; Najm, I; Vanderklish, P, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 6 (66.67) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| VanSickle, EA | 1 |
| Michael, J | 1 |
| Bachmann, AS | 1 |
| Rajasekaran, S | 1 |
| Prokop, JW | 1 |
| Kuzniecky, R | 1 |
| Hofstede, FC | 1 |
| Steindl, K | 1 |
| Rauch, A | 1 |
| Lipson, MH | 1 |
| Bupp, CP | 1 |
| Priotto, G | 1 |
| Kasparian, S | 1 |
| Mutombo, W | 1 |
| Ngouama, D | 1 |
| Ghorashian, S | 1 |
| Arnold, U | 1 |
| Ghabri, S | 1 |
| Baudin, E | 1 |
| Buard, V | 1 |
| Kazadi-Kyanza, S | 1 |
| Ilunga, M | 1 |
| Mutangala, W | 1 |
| Pohlig, G | 1 |
| Schmid, C | 1 |
| Karunakara, U | 1 |
| Torreele, E | 1 |
| Kande, V | 1 |
| Gerrish, KE | 1 |
| Fuller, DJ | 1 |
| Gerner, EW | 1 |
| Gensler, HL | 1 |
| Milord, F | 1 |
| Pépin, J | 1 |
| Loko, L | 1 |
| Ethier, L | 1 |
| Mpia, B | 1 |
| Herberg, LJ | 1 |
| Rose, IC | 1 |
| de Belleroche, JS | 1 |
| Mintz, M | 1 |
| Najm, I | 1 |
| el-Skaf, G | 1 |
| Massicotte, G | 1 |
| Vanderklish, P | 1 |
| Lynch, G | 1 |
| Baudry, M | 1 |
| Hayashi, Y | 1 |
| Hattori, Y | 1 |
| Hori, Y | 1 |
| de Vera, N | 1 |
| Artigas, F | 1 |
| Serratosa, J | 1 |
| Martínez, E | 1 |
| Genedani, S | 1 |
| Bernardi, M | 1 |
| Botticelli, A | 1 |
| Bertolini, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Study Comparing the Nifurtimox-Eflornithine Combination With the Standard Eflornithine Regimen for the Treatment of Trypanosoma Brucei Gambiense Human African Trypanosomiasis in the Meningoencephalitic Phase[NCT00146627] | Phase 3 | 280 participants (Anticipated) | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for eflornithine and Seizures
| Article | Year |
|---|---|
Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial.
Topics: Administration, Oral; Adult; Animals; Congo; Democratic Republic of the Congo; Drug Administration S | 2009 |
Efficacy and toxicity of eflornithine for treatment of Trypanosoma brucei gambiense sleeping sickness.
Topics: Administration, Oral; Animals; Cerebrospinal Fluid; Democratic Republic of the Congo; Diarrhea; Eflo | 1992 |
7 other studies available for eflornithine and Seizures
| Article | Year |
|---|---|
Expanding the phenotype: Four new cases and hope for treatment in Bachmann-Bupp syndrome.
Topics: Adolescent; Adult; Alopecia; Brain; Child; Child, Preschool; Developmental Disabilities; Dicarboxyli | 2021 |
Inhibition of DFMO-induced audiogenic seizures by chlordiazepoxide.
Topics: Acoustic Stimulation; Animals; Brain; Chlordiazepoxide; Eflornithine; Female; gamma-Aminobutyric Aci | 1993 |
Ornithine decarboxylase induction and polyamine synthesis in the kindling of seizures: the effect of alpha-difluoromethylornithine.
Topics: Animals; Biogenic Polyamines; Eflornithine; Electric Stimulation; Enzyme Induction; Kindling, Neurol | 1992 |
Changes in polyamine levels and spectrin degradation following kainate-induced seizure activity: effect of difluoromethylornithine.
Topics: Animals; Eflornithine; Hippocampus; Kainic Acid; Male; Polyamines; Rats; Seizures; Spectrin | 1992 |
Involvement of putrescine in the development of kindled seizure in rats.
Topics: Amygdala; Animals; Brain; Eflornithine; Electroencephalography; Frontal Lobe; Kindling, Neurologic; | 1992 |
Changes in polyamine levels in rat brain after systemic kainic acid administration: relationship to convulsant activity and brain damage.
Topics: Animals; Body Weight; Brain; Brain Damage, Chronic; Eflornithine; Injections, Intraperitoneal; Kaini | 1991 |
Convulsive syndrome induced by the intracerebroventricular injection of alpha-difluoromethylornithine in rats.
Topics: Animals; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Eflornithine; Female; Injections | 1985 |