Page last updated: 2024-10-25

eflornithine and Pyrexia

eflornithine has been researched along with Pyrexia in 5 studies

Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.

Research Excerpts

ExcerptRelevanceReference
"Endogenous concentrations of putrescine, spermidine, spermine and related biosynthetic enzymes were not affected by the administration of bacterial endotoxin and the subsequent development of fever in rabbits."7.67Evidence against putrescine and polyamines as endogenous mediators of fever. ( Dascombe, MJ; Haegele, KD, 1985)
" Patients aged 15 years or older with confirmed second-stage T b gambiense infection were randomly assigned by computer-generated randomisation sequence to receive intravenous eflornithine (400 mg/kg per day, every 6 h; n=144) for 14 days or intravenous eflornithine (400 mg/kg per day, every 12 h) for 7 days with oral nifurtimox (15 mg/kg per day, every 8 h) for 10 days (NECT; n=143)."5.14Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial. ( Arnold, U; Baudin, E; Buard, V; Ghabri, S; Ghorashian, S; Ilunga, M; Kande, V; Karunakara, U; Kasparian, S; Kazadi-Kyanza, S; Mutangala, W; Mutombo, W; Ngouama, D; Pohlig, G; Priotto, G; Schmid, C; Torreele, E, 2009)
"Endogenous concentrations of putrescine, spermidine, spermine and related biosynthetic enzymes were not affected by the administration of bacterial endotoxin and the subsequent development of fever in rabbits."3.67Evidence against putrescine and polyamines as endogenous mediators of fever. ( Dascombe, MJ; Haegele, KD, 1985)
"Today, human African trypanosomiasis is an extremely rare diagnosis, especially in children."1.36[Human African trypanosomiasis: description of two pediatric cases in Yaoundé, Cameroon]. ( Akazong, CA; Boula, A; Chelo, D; Ebo'O Eyenga, V; Kinkela, MN; Kohagne Tongue, L; Kyebyene, A; Tietche, F, 2010)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's2 (40.00)18.2507
2000's1 (20.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Priotto, G1
Kasparian, S1
Mutombo, W1
Ngouama, D1
Ghorashian, S1
Arnold, U1
Ghabri, S1
Baudin, E1
Buard, V1
Kazadi-Kyanza, S1
Ilunga, M1
Mutangala, W1
Pohlig, G1
Schmid, C1
Karunakara, U1
Torreele, E1
Kande, V1
Kinkela, MN1
Chelo, D1
Boula, A1
Ebo'O Eyenga, V1
Kohagne Tongue, L1
Akazong, CA1
Kyebyene, A1
Tietche, F1
Ganju, V1
Edmonson, JH1
Buckner, JC1
Blanchot, I1
Dabadie, A1
Tell, G1
Guiguen, C1
Faugère, B1
Plat-Pelle, AM1
Roussey, M1
Dascombe, MJ1
Haegele, KD1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Clinical Study Comparing the Nifurtimox-Eflornithine Combination With the Standard Eflornithine Regimen for the Treatment of Trypanosoma Brucei Gambiense Human African Trypanosomiasis in the Meningoencephalitic Phase[NCT00146627]Phase 3280 participants (Anticipated)InterventionalCompleted
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for eflornithine and Pyrexia

ArticleYear
Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial.
    Lancet (London, England), 2009, Jul-04, Volume: 374, Issue:9683

    Topics: Administration, Oral; Adult; Animals; Congo; Democratic Republic of the Congo; Drug Administration S

2009
Phase I study of combined alpha interferon, alpha difluoromethylornithine (DFMO), and doxorubicin in advanced malignancy.
    Investigational new drugs, 1994, Volume: 12, Issue:1

    Topics: Doxorubicin; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Eflornithine; Fatigue; Fe

1994

Other Studies

3 other studies available for eflornithine and Pyrexia

ArticleYear
[Human African trypanosomiasis: description of two pediatric cases in Yaoundé, Cameroon].
    Medecine tropicale : revue du Corps de sante colonial, 2010, Volume: 70, Issue:1

    Topics: Cameroon; Child; Child, Preschool; Eflornithine; Fever; Humans; Male; Trypanocidal Agents; Trypanoso

2010
[Recurrent fever episodes in an African child: diagnostic difficulties of trypanosomiasis in France].
    Pediatrie, 1992, Volume: 47, Issue:3

    Topics: Angola; Child, Preschool; Eflornithine; Fever; France; Humans; Male; Recurrence; Trypanosomiasis, Af

1992
Evidence against putrescine and polyamines as endogenous mediators of fever.
    The Journal of pharmacy and pharmacology, 1985, Volume: 37, Issue:5

    Topics: Animals; Eflornithine; Endotoxins; Fever; Ornithine; Polyamines; Putrescine; Rabbits; Shigella dysen

1985