eflornithine has been researched along with Pyrexia in 5 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Endogenous concentrations of putrescine, spermidine, spermine and related biosynthetic enzymes were not affected by the administration of bacterial endotoxin and the subsequent development of fever in rabbits." | 7.67 | Evidence against putrescine and polyamines as endogenous mediators of fever. ( Dascombe, MJ; Haegele, KD, 1985) |
| " Patients aged 15 years or older with confirmed second-stage T b gambiense infection were randomly assigned by computer-generated randomisation sequence to receive intravenous eflornithine (400 mg/kg per day, every 6 h; n=144) for 14 days or intravenous eflornithine (400 mg/kg per day, every 12 h) for 7 days with oral nifurtimox (15 mg/kg per day, every 8 h) for 10 days (NECT; n=143)." | 5.14 | Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial. ( Arnold, U; Baudin, E; Buard, V; Ghabri, S; Ghorashian, S; Ilunga, M; Kande, V; Karunakara, U; Kasparian, S; Kazadi-Kyanza, S; Mutangala, W; Mutombo, W; Ngouama, D; Pohlig, G; Priotto, G; Schmid, C; Torreele, E, 2009) |
| "Endogenous concentrations of putrescine, spermidine, spermine and related biosynthetic enzymes were not affected by the administration of bacterial endotoxin and the subsequent development of fever in rabbits." | 3.67 | Evidence against putrescine and polyamines as endogenous mediators of fever. ( Dascombe, MJ; Haegele, KD, 1985) |
| "Today, human African trypanosomiasis is an extremely rare diagnosis, especially in children." | 1.36 | [Human African trypanosomiasis: description of two pediatric cases in Yaoundé, Cameroon]. ( Akazong, CA; Boula, A; Chelo, D; Ebo'O Eyenga, V; Kinkela, MN; Kohagne Tongue, L; Kyebyene, A; Tietche, F, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Priotto, G | 1 |
| Kasparian, S | 1 |
| Mutombo, W | 1 |
| Ngouama, D | 1 |
| Ghorashian, S | 1 |
| Arnold, U | 1 |
| Ghabri, S | 1 |
| Baudin, E | 1 |
| Buard, V | 1 |
| Kazadi-Kyanza, S | 1 |
| Ilunga, M | 1 |
| Mutangala, W | 1 |
| Pohlig, G | 1 |
| Schmid, C | 1 |
| Karunakara, U | 1 |
| Torreele, E | 1 |
| Kande, V | 1 |
| Kinkela, MN | 1 |
| Chelo, D | 1 |
| Boula, A | 1 |
| Ebo'O Eyenga, V | 1 |
| Kohagne Tongue, L | 1 |
| Akazong, CA | 1 |
| Kyebyene, A | 1 |
| Tietche, F | 1 |
| Ganju, V | 1 |
| Edmonson, JH | 1 |
| Buckner, JC | 1 |
| Blanchot, I | 1 |
| Dabadie, A | 1 |
| Tell, G | 1 |
| Guiguen, C | 1 |
| Faugère, B | 1 |
| Plat-Pelle, AM | 1 |
| Roussey, M | 1 |
| Dascombe, MJ | 1 |
| Haegele, KD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Study Comparing the Nifurtimox-Eflornithine Combination With the Standard Eflornithine Regimen for the Treatment of Trypanosoma Brucei Gambiense Human African Trypanosomiasis in the Meningoencephalitic Phase[NCT00146627] | Phase 3 | 280 participants (Anticipated) | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for eflornithine and Pyrexia
| Article | Year |
|---|---|
Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial.
Topics: Administration, Oral; Adult; Animals; Congo; Democratic Republic of the Congo; Drug Administration S | 2009 |
Phase I study of combined alpha interferon, alpha difluoromethylornithine (DFMO), and doxorubicin in advanced malignancy.
Topics: Doxorubicin; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Eflornithine; Fatigue; Fe | 1994 |
3 other studies available for eflornithine and Pyrexia
| Article | Year |
|---|---|
[Human African trypanosomiasis: description of two pediatric cases in Yaoundé, Cameroon].
Topics: Cameroon; Child; Child, Preschool; Eflornithine; Fever; Humans; Male; Trypanocidal Agents; Trypanoso | 2010 |
[Recurrent fever episodes in an African child: diagnostic difficulties of trypanosomiasis in France].
Topics: Angola; Child, Preschool; Eflornithine; Fever; France; Humans; Male; Recurrence; Trypanosomiasis, Af | 1992 |
Evidence against putrescine and polyamines as endogenous mediators of fever.
Topics: Animals; Eflornithine; Endotoxins; Fever; Ornithine; Polyamines; Putrescine; Rabbits; Shigella dysen | 1985 |