eflornithine has been researched along with Psoriasis in 5 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Psoriasis: A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kousa, M | 1 |
| Käpyaho, K | 2 |
| Lauharanta, J | 1 |
| Linnamaa, K | 1 |
| Jänne, J | 2 |
| Mustakallio, K | 1 |
| Kariniemi, AL | 1 |
| Virtanen, I | 1 |
| McCullough, JL | 1 |
| Weinstein, GD | 1 |
| Rosenblum, MG | 1 |
| Jenkins, JJ | 1 |
| Grosshans, E | 2 |
| Henry, M | 2 |
| Tell, G | 2 |
| Schechter, PJ | 2 |
| Böhlen, P | 1 |
| Grove, J | 2 |
| Koch-Weser, J | 2 |
| Juillard, J | 1 |
5 other studies available for eflornithine and Psoriasis
| Article | Year |
|---|---|
Methylglyoxal BIS (guanylhydrazone) and alpha-difluoromethylornithine-induced polyamine deprivation in psoriatic lesions.
Topics: Carboxy-Lyases; Dose-Response Relationship, Drug; Eflornithine; Guanidines; Humans; Injections, Intr | 1982 |
Effect of polyamine antimetabolites on cultured human keratinocytes from normal and uninvolved psoriatic skin.
Topics: Antimetabolites; Cell Division; Cells, Cultured; DNA; Eflornithine; Guanidines; Humans; Keratins; Mi | 1984 |
Percutaneous penetration of methylglyoxal bis(guanylhydrazone): effects on hairless mouse epidermis in vivo.
Topics: Administration, Topical; Animals; DNA; Eflornithine; Guanidines; In Vitro Techniques; Mice; Mice, Ha | 1983 |
[Polyamines in psoriasis].
Topics: Anthralin; Carboxy-Lyases; Chemical Phenomena; Chemistry; Double-Blind Method; Eflornithine; Humans; | 1980 |
Comparative effects of topical anthralin and difluoromethylornithine (alpha DFMO) on epidermal polyamine concentration in psoriasis.
Topics: Anthracenes; Anthralin; Eflornithine; Humans; Ornithine; Polyamines; Psoriasis; Skin | 1981 |