eflornithine has been researched along with Prostatic Intraepithelial Neoplasia in 3 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Prostatic Intraepithelial Neoplasia: A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Christov, KT | 1 |
| Moon, RC | 1 |
| Lantvit, DD | 1 |
| Boone, CW | 1 |
| Kelloff, GJ | 1 |
| Steele, VE | 1 |
| Lubet, RA | 1 |
| Pezzuto, JM | 1 |
| Ranger-Moore, J | 1 |
| Alberts, DS | 1 |
| Montironi, R | 2 |
| Garcia, F | 1 |
| Davis, J | 1 |
| Frank, D | 1 |
| Brewer, M | 1 |
| Mariuzzi, GM | 1 |
| Bartels, HG | 1 |
| Bartels, PH | 2 |
| Mazzucchelli, R | 1 |
| Marshall, JR | 1 |
1 review available for eflornithine and Prostatic Intraepithelial Neoplasia
| Article | Year |
|---|---|
Prostate cancer prevention: review of target populations, pathological biomarkers, and chemopreventive agents.
Topics: Adenocarcinoma; Androgen Antagonists; Animals; Antineoplastic Agents; Clinical Trials as Topic; Diet | 1999 |
2 other studies available for eflornithine and Prostatic Intraepithelial Neoplasia
| Article | Year |
|---|---|
Prostate intraepithelial neoplasia in Noble rats, a potential intermediate endpoint for chemoprevention studies.
Topics: Animals; Antineoplastic Agents; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Drug Scree | 2004 |
Karyometry in the early detection and chemoprevention of intraepithelial lesions.
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma; Carcinoma, Ductal, Breast; Disease Progression; | 2005 |