eflornithine has been researched along with Pregnancy in 48 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our previous study has demonstrated that dietary arginine supplementation during early pregnancy enhanced embryo implantation in rats." | 7.79 | Arginine enhances embryo implantation in rats through PI3K/PKB/mTOR/NO signaling pathway during early pregnancy. ( Huang, Z; Mao, X; Qiao, S; Wang, F; Wu, G; Zeng, X, 2013) |
| " These COX-2 and ODC inhibitor drugs were not overtly toxic at the doses used when administered to mice after weaning." | 5.31 | Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas, and selective toxicity against Apc mutant embryos. ( Cole, CE; Hawk, ET; Jacoby, RF; Kelloff, G; Lubet, RA; Newton, MA; Tutsch, K, 2000) |
| "Our previous study has demonstrated that dietary arginine supplementation during early pregnancy enhanced embryo implantation in rats." | 3.79 | Arginine enhances embryo implantation in rats through PI3K/PKB/mTOR/NO signaling pathway during early pregnancy. ( Huang, Z; Mao, X; Qiao, S; Wang, F; Wu, G; Zeng, X, 2013) |
| " When DL-alpha-difluoromethylornithine (DFMO), a highly selective irreversible inhibitor of ODC, is given during the early post-implantation period, when ODC activity in the conceptus is rapidly rising and reaches its highest values, it causes pregnancy arrest." | 3.66 | Contragestational effects of DL-alpha-difluoro-methylornithine, an irreversible inhibitor of ornithine decarboxylase, in the hamster. ( Colombo, G; Galliani, G; Luzzani, F, 1983) |
| "Intraperitoneal injection of alpha-difluoromethylornithine (DFMO) at a dose of 200 mg/kg, twice a day, during days 4-7 of pregnancy caused inhibition of embryogenesis in rats." | 3.66 | Alpha-difluoromethylornithine as a postcoitally effective antifertility agent in female rats. ( Reddy, PR; Rukmini, V, 1981) |
| "Changes in uterine ornithine decarboxylase (ODC) activity throughout pregnancy and the importance of progesterone in the regulation of this enzyme during the early post-implantation period have been studied in the hamster." | 3.66 | Evidence for a role of progesterone in the control of uterine ornithine decarboxylase in the pregnant hamster. ( Colombo, G; Galliani, G; Luzzani, F, 1982) |
| " Safety was further assessed based on treatment emergent adverse events (AEs) occurring during hospitalisation." | 2.77 | In-hospital safety in field conditions of nifurtimox eflornithine combination therapy (NECT) for T. b. gambiense sleeping sickness. ( Blesson, S; Blum, J; Ghabri, S; Ilunga, M; Kande, V; Kisala, M; Kuemmerle, A; Lumpungu, I; Mordt, OV; Mubwa, N; Mutanda, S; Mutombo, W; Nganzobo, P; Schmid, C; Tete, D, 2012) |
| " These COX-2 and ODC inhibitor drugs were not overtly toxic at the doses used when administered to mice after weaning." | 1.31 | Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas, and selective toxicity against Apc mutant embryos. ( Cole, CE; Hawk, ET; Jacoby, RF; Kelloff, G; Lubet, RA; Newton, MA; Tutsch, K, 2000) |
| "The roles of polyamines in intrauterine growth restriction (IUGR) is studied." | 1.31 | Inhibition of placental ornithine decarboxylase by DL-alpha-difluoro-methyl ornithine causes fetal growth restriction in rat. ( Hiramatsu, Y; Ishida, M; Kudo, T; Masuyama, H; Mizutani, Y, 2002) |
| "Ethylnitrosourea was given to pregnant rats as a single i." | 1.28 | Study of postnatal effects of chemopreventive agents on offspring of ethylnitrosourea-induced transplacental carcinogenesis in rats. I. Influence of retinol acetate, alpha-tocopherol acetate, thiamine chloride, sodium selenite, and alpha-difluoromethylorn ( Alexandrov, VA; Bespalov, VG; Boone, CW; Kelloff, GJ; Malone, WF, 1991) |
| "She tested positive and suspected pneumocystosis (later confirmed) and began treatment with IV Septrin and hydrocortisone." | 1.28 | A maternal death caused by AIDS. Case report. ( Barton, SE; Gazzard, B; Kell, PD; Marwood, RP; Nelson, M; Smith, DE, 1991) |
| "Imipramine (IMI) was administered s." | 1.27 | Effect of prenatal imipramine exposure on development of the postnatal rat heart and brain. ( Delongchamp, RR; Harmon, JR; Kimmel, GL; Webb, PJ, 1986) |
| "Spermine levels were not decreased and in some cases were actually increased during the course of alpha-difluoromethylornithine administration; assessment of total organ content of spermine or total polyamines per organ (putrescine + spermidine + spermine) indicated that the tissues were still actively increasing their net polyamine content despite continued inhibition of ODC." | 1.26 | Ornithine decarboxylase and polyamines in tissues of the neonatal rat: effects of alpha-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase. ( Barnes, GA; Bartolome, J; Lerea, L; Seidler, FJ; Slotkin, TA; Trepanier, PA; Weigel, SJ; Whitmore, WL, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (50.00) | 18.7374 |
| 1990's | 7 (14.58) | 18.2507 |
| 2000's | 10 (20.83) | 29.6817 |
| 2010's | 5 (10.42) | 24.3611 |
| 2020's | 2 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Kuemmerle, A | 2 |
| Schmid, C | 2 |
| Bernhard, S | 1 |
| Kande, V | 2 |
| Mutombo, W | 2 |
| Ilunga, M | 2 |
| Lumpungu, I | 2 |
| Mutanda, S | 2 |
| Nganzobo, P | 2 |
| Tete, DN | 1 |
| Kisala, M | 2 |
| Burri, C | 1 |
| Blesson, S | 2 |
| Valverde Mordt, O | 1 |
| Shi, C | 1 |
| Yan, Z | 1 |
| Zhang, Y | 1 |
| Qin, L | 1 |
| Wu, W | 1 |
| Gao, C | 1 |
| Gao, L | 1 |
| Liu, J | 1 |
| Cui, Y | 1 |
| Fenelon, JC | 1 |
| Murphy, BD | 1 |
| Kong, X | 1 |
| Wang, X | 1 |
| Yin, Y | 1 |
| Li, X | 1 |
| Gao, H | 1 |
| Bazer, FW | 1 |
| Wu, G | 2 |
| López-García, C | 1 |
| López-Contreras, AJ | 1 |
| Cremades, A | 1 |
| Castells, MT | 1 |
| Marín, F | 1 |
| Schreiber, F | 1 |
| Peñafiel, R | 1 |
| Oba, A | 1 |
| Gahtse, A | 1 |
| Ekouya Bowassa, G | 1 |
| Nika, E | 1 |
| Zeng, X | 1 |
| Mao, X | 1 |
| Huang, Z | 1 |
| Wang, F | 1 |
| Qiao, S | 1 |
| Blum, J | 1 |
| Ghabri, S | 1 |
| Tete, D | 1 |
| Mubwa, N | 1 |
| Mordt, OV | 1 |
| Feith, DJ | 1 |
| Bol, DK | 1 |
| Carboni, JM | 1 |
| Lynch, MJ | 1 |
| Sass-Kuhn, S | 1 |
| Shoop, PL | 1 |
| Shantz, LM | 1 |
| Balasegaram, M | 1 |
| Dejene, S | 1 |
| Tinnemann, P | 1 |
| Perkins, S | 1 |
| Davidson, R | 1 |
| Zhao, YC | 1 |
| Chi, YJ | 1 |
| Yu, YS | 1 |
| Liu, JL | 1 |
| Su, RW | 1 |
| Ma, XH | 1 |
| Shan, CH | 1 |
| Yang, ZM | 1 |
| Slotkin, TA | 7 |
| Grignolo, A | 1 |
| Whitmore, WL | 4 |
| Lerea, L | 2 |
| Trepanier, PA | 2 |
| Barnes, GA | 2 |
| Weigel, SJ | 2 |
| Seidler, FJ | 2 |
| Bartolome, J | 3 |
| Fozard, JR | 4 |
| Part, ML | 3 |
| Méndez, JD | 2 |
| Diaz-Flores, M | 1 |
| Durán, G | 1 |
| Hicks, JJ | 2 |
| Galliani, G | 2 |
| Colombo, G | 2 |
| Luzzani, F | 2 |
| Persons, D | 1 |
| Yang, P | 1 |
| Baylin, SB | 1 |
| Luk, GD | 1 |
| Prakash, NJ | 3 |
| Grove, J | 3 |
| Schechter, PJ | 1 |
| Sjoerdsma, A | 1 |
| Koch-Weser, J | 1 |
| Reddy, PR | 1 |
| Rukmini, V | 1 |
| Gritli-Linde, A | 1 |
| Linde, A | 1 |
| Brock, M | 1 |
| Henley, CM | 1 |
| Sparapani, M | 1 |
| Virgili, M | 1 |
| Caprini, M | 1 |
| Facchinetti, F | 1 |
| Ciani, E | 1 |
| Contestabile, A | 1 |
| Kirchner, DL | 1 |
| Mercieca, MD | 1 |
| Crowell, JA | 1 |
| Levine, BS | 1 |
| Jacoby, RF | 1 |
| Cole, CE | 1 |
| Tutsch, K | 1 |
| Newton, MA | 1 |
| Kelloff, G | 1 |
| Hawk, ET | 1 |
| Lubet, RA | 1 |
| Rillema, JA | 2 |
| Collins, S | 1 |
| Williams, CH | 1 |
| Lin, CH | 1 |
| Lyons, H | 1 |
| Seelbach, MS | 1 |
| Tolia, V | 1 |
| Vijesurier, R | 1 |
| Ferguson, SA | 1 |
| Cada, AM | 1 |
| Gray, EP | 1 |
| Paule, MG | 1 |
| Ishida, M | 1 |
| Hiramatsu, Y | 1 |
| Masuyama, H | 1 |
| Mizutani, Y | 1 |
| Kudo, T | 1 |
| Thyssen, SM | 1 |
| Hockl, PF | 1 |
| Chamson, A | 1 |
| Lux-Lantos, VA | 1 |
| Libertun, C | 1 |
| Alexandrov, VA | 1 |
| Bespalov, VG | 1 |
| Boone, CW | 1 |
| Kelloff, GJ | 1 |
| Malone, WF | 1 |
| Kell, PD | 1 |
| Barton, SE | 1 |
| Smith, DE | 1 |
| Nelson, M | 1 |
| Marwood, RP | 1 |
| Gazzard, B | 1 |
| Markwell, MA | 1 |
| Berger, SP | 1 |
| Paul, SM | 1 |
| Bell, JM | 3 |
| O'Toole, BA | 1 |
| Huffman, KW | 1 |
| Gibson, JP | 1 |
| Gray, JA | 1 |
| Rehnberg, BF | 1 |
| Rogers, EH | 1 |
| Lau, C | 1 |
| Kavlock, RJ | 1 |
| Oppat, CA | 1 |
| Harmon, JR | 1 |
| Webb, PJ | 1 |
| Kimmel, GL | 1 |
| Delongchamp, RR | 1 |
| Zwierzchowski, L | 1 |
| Członkowska, M | 1 |
| Guszkiewicz, A | 1 |
| Hitier, Y | 1 |
| Champigny, O | 1 |
| Bourdel, G | 1 |
| Yáñez, R | 1 |
| Wong, C | 1 |
| Madwed, DS | 1 |
| Pisano, MM | 1 |
| Greene, RM | 1 |
| Hassoun, EA | 1 |
| Arif, AT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Study to Assess the Clinical Tolerability, Feasibility and Effectiveness Under Field Conditions of the Combination of Nifurtimox and Eflornithine (NECT) for the Treatment of T.b.Gambiense Human African Trypanosomiasis (HAT) in the Meningo-encepha[NCT00906880] | Phase 4 | 630 participants (Actual) | Interventional | 2009-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for eflornithine and Pregnancy
| Article | Year |
|---|---|
Effectiveness of Nifurtimox Eflornithine Combination Therapy (NECT) in T. b. gambiense second stage sleeping sickness patients in the Democratic Republic of Congo: Report from a field study.
Topics: Adolescent; Adult; Aged; Antiprotozoal Agents; Child; Child, Preschool; Democratic Republic of the C | 2021 |
In-hospital safety in field conditions of nifurtimox eflornithine combination therapy (NECT) for T. b. gambiense sleeping sickness.
Topics: Adolescent; Adult; Child; Child, Preschool; Democratic Republic of the Congo; Drug Therapy, Combinat | 2012 |
46 other studies available for eflornithine and Pregnancy
| Article | Year |
|---|---|
Effects of putrescine on the quality and epigenetic modification of mouse oocytes during
Topics: Animals; Eflornithine; Epigenesis, Genetic; Female; Humans; In Vitro Oocyte Maturation Techniques; I | 2022 |
Inhibition of polyamine synthesis causes entry of the mouse blastocyst into embryonic diapause.
Topics: Animals; Blastocyst; Diapause; Eflornithine; Embryo Implantation; Embryonic Development; Endometrium | 2017 |
Putrescine stimulates the mTOR signaling pathway and protein synthesis in porcine trophectoderm cells.
Topics: Animals; Cell Proliferation; Cells, Cultured; Ectoderm; Eflornithine; Female; Pregnancy; Protein Bio | 2014 |
Molecular and morphological changes in placenta and embryo development associated with the inhibition of polyamine synthesis during midpregnancy in mice.
Topics: Androstenedione; Animals; Decidua; Eflornithine; Embryonic Development; Enzyme Inhibitors; Female; G | 2008 |
[Congenital human African trypanosomiasis: an observation at the University Hospital of Brazzaville (Congo)].
Topics: Animals; Congo; Eflornithine; Fatal Outcome; Female; Hospitals, University; Humans; Infant, Newborn; | 2011 |
Arginine enhances embryo implantation in rats through PI3K/PKB/mTOR/NO signaling pathway during early pregnancy.
Topics: Androstadienes; Animals; Arginine; Dietary Supplements; Eflornithine; Embryo Implantation; Female; M | 2013 |
Induction of ornithine decarboxylase activity is a necessary step for mitogen-activated protein kinase kinase-induced skin tumorigenesis.
Topics: Animals; Eflornithine; Enzyme Induction; Female; Male; MAP Kinase Kinase 1; Mice; Mice, Inbred ICR; | 2005 |
Examples of tropical disease control in the humanitarian medical programmes of MSF and Merlin.
Topics: Antimalarials; Artemether; Artemisinins; Attitude to Health; Child; Child, Preschool; Communicable D | 2006 |
Polyamines are essential in embryo implantation: expression and function of polyamine-related genes in mouse uterus during peri-implantation period.
Topics: Adenosylmethionine Decarboxylase; Animals; Eflornithine; Embryo Implantation; Female; Gene Expressio | 2008 |
Impaired development of central and peripheral catecholamine neurotransmitter systems in preweanling rats treated with alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase.
Topics: Animals; Animals, Newborn; Brain; Carboxy-Lyases; Dopamine; Eflornithine; Female; Neurons; Neurotran | 1982 |
Methods for the study of the experimental interruption of pregnancy by ornithine decarboxylase inhibitors: effects of DL-alpha-difluoromethylornithine.
Topics: Abortifacient Agents; Abortifacient Agents, Nonsteroidal; Animals; Dose-Response Relationship, Drug; | 1983 |
Inhibition of rat embryonic development by the intrauterine administration of alpha-difluoromethylornithine.
Topics: Animals; Contraceptives, Postcoital; Contraceptives, Postcoital, Synthetic; Eflornithine; Embryo Imp | 1983 |
Contragestational effects of DL-alpha-difluoro-methylornithine, an irreversible inhibitor of ornithine decarboxylase, in the hamster.
Topics: Animals; Contraceptives, Postcoital; Contraceptives, Postcoital, Synthetic; Cricetinae; Eflornithine | 1983 |
Polyamines in brain and heart of the neonatal rat: effects of inhibitors of ornithine decarboxylase and spermidine synthase.
Topics: Animals; Animals, Newborn; Brain; Cyclohexylamines; Dose-Response Relationship, Drug; Eflornithine; | 1984 |
Polyamines and intestinal growth: absolute requirement for ODC activity in adaptation during lactation.
Topics: Adaptation, Physiological; Adenosylmethionine Decarboxylase; Animals; Cell Division; Eflornithine; F | 1984 |
L-Ornithine decarboxylase:an essential role in early mammalian embryogenesis.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Eflornithine; Embryo, Mammalian; Female; | 1980 |
Inhibition of murine embryonic development by alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Eflornithine; Embryo, Mammalian; Female; | 1980 |
Ovarian function in the rat following irreversible inhibition of L-ornithine decarboxylase.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Eflornithine; Estrus; Female; Mitoguazone | 1980 |
Alpha-difluoromethylornithine as a postcoitally effective antifertility agent in female rats.
Topics: Animals; Contraceptives, Postcoital; Contraceptives, Postcoital, Synthetic; Eflornithine; Embryo Imp | 1981 |
Ornithine decarboxylase and polyamines in tissues of the neonatal rat: effects of alpha-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase.
Topics: Animals; Animals, Newborn; Brain; Carboxy-Lyases; Eflornithine; Female; Heart; Kidney; Myocardium; O | 1982 |
Evidence for a role of progesterone in the control of uterine ornithine decarboxylase in the pregnant hamster.
Topics: Animals; Antineoplastic Agents; Carboxy-Lyases; Castration; Cricetinae; Dinoprost; Eflornithine; Fem | 1982 |
Localization of ornithine decarboxylase in mouse teeth. An in vitro and in vivo study.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Cycloheximide; Eflornithine; Female; Kidney Tubul | 1994 |
Postnatal changes in cochlear polyamine metabolism in the rat.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cochlea; Eflornithine; Female; Organ of Corti; Orni | 1994 |
Effects of gestational or neonatal treatment with alpha-difluoromethylornithine on ornithine decarboxylase and polyamines in developing rat brain and on adult rat neurochemistry.
Topics: Animals; Animals, Newborn; Body Weight; Brain Chemistry; Cerebellum; Choline O-Acetyltransferase; Ef | 1996 |
Developmental toxicity studies of 2-(difluoromethyl)-dl-ornithine (DFMO) in rats and rabbits.
Topics: Animals; Body Weight; Bone and Bones; Cesarean Section; Dose-Response Relationship, Drug; Eflornithi | 1999 |
Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas, and selective toxicity against Apc mutant embryos.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhi | 2000 |
Prolactin stimulation of iodide uptake and incorporation into protein is polyamine-dependent in mouse mammary gland explants.
Topics: Adenosylmethionine Decarboxylase; Animals; Eflornithine; Enzyme Inhibitors; Female; Iodides; Iodine | 2000 |
Induction of gastric ornithine decarboxylase in early weaning rats.
Topics: Animals; Body Weight; Eflornithine; Enzyme Induction; Enzyme Inhibitors; Female; Gastric Mucosa; Mod | 2001 |
No alterations in the performance of two interval timing operant tasks after alpha-difluoromethylornithine (DFMO)-induced cerebellar stunting.
Topics: Animals; Animals, Newborn; Association Learning; Brain Mapping; Cerebellum; Choice Behavior; Conditi | 2001 |
Inhibition of placental ornithine decarboxylase by DL-alpha-difluoro-methyl ornithine causes fetal growth restriction in rat.
Topics: Animals; Blood Proteins; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Eati | 2002 |
Effects of polyamines on the release of gonadotropin-releasing hormone and gonadotropins in developing female rats.
Topics: Animals; Cells, Cultured; Eflornithine; Female; Gonadotropin-Releasing Hormone; Gonadotropins; Pitui | 2002 |
Study of postnatal effects of chemopreventive agents on offspring of ethylnitrosourea-induced transplacental carcinogenesis in rats. I. Influence of retinol acetate, alpha-tocopherol acetate, thiamine chloride, sodium selenite, and alpha-difluoromethylorn
Topics: alpha-Tocopherol; Animals; Antioxidants; Diterpenes; Eflornithine; Ethylnitrosourea; Female; Kidney | 1991 |
A maternal death caused by AIDS. Case report.
Topics: Acquired Immunodeficiency Syndrome; Adult; Eflornithine; Female; Humans; Isoniazid; Opportunistic In | 1991 |
The polyamine synthesis inhibitor alpha-difluoromethylornithine blocks NMDA-induced neurotoxicity.
Topics: Animals; Biogenic Polyamines; Cells, Cultured; Eflornithine; Female; Mice; Mice, Inbred C57BL; N-Met | 1990 |
Effects of alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase, on nucleic acids and proteins in developing rat brain: critical perinatal periods for regional selectivity.
Topics: Aging; Animals; Body Weight; Brain; DNA; Eflornithine; Female; Injections, Subcutaneous; Nerve Tissu | 1986 |
Effects of eflornithine hydrochloride (DFMO) on fetal development in rats and rabbits.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Dose-Response Relationship, Drug; Eflor | 1989 |
Prenatal alpha-difluoromethylornithine treatment: effects on postnatal renal growth and function in the rat.
Topics: Analysis of Variance; Animals; Body Weight; Creatinine; Eflornithine; Female; Gestational Age; Kidne | 1989 |
Cyclic nucleotides and polyamines in prolactin stimulation of lactose biosynthesis.
Topics: Animals; Eflornithine; Female; Lactose; Mammary Glands, Animal; Mice; Mitoguazone; Nucleotides, Cycl | 1989 |
Effect of prenatal imipramine exposure on development of the postnatal rat heart and brain.
Topics: Aging; Animals; Body Weight; Brain; Dihydroalprenolol; Eflornithine; Female; Heart; Imipramine; Litt | 1986 |
Effect of polyamine limitation on DNA synthesis and development of mouse preimplantation embryos in vitro.
Topics: Animals; Blastocyst; Culture Media; DNA; Eflornithine; Embryonic Development; Female; In Vitro Techn | 1986 |
Urea concentration and ornithine decarboxylase in liver of female rats.
Topics: Animals; Carbamoyl-Phosphate Synthase (Ammonia); Eflornithine; Female; Glutamates; Kinetics; Liver; | 1986 |
Uterine arginase inhibition affect the rat embryonic development.
Topics: Animals; Arginase; Eflornithine; Embryo Implantation; Embryonic and Fetal Development; Female; Ornit | 1986 |
Critical development periods for inhibition of ornithine decarboxylase by alpha-difluoromethylornithine: effects on ontogeny of sensorimotor behavior.
Topics: Animals; Behavior, Animal; Eflornithine; Female; Motor Activity; Nervous System; Ornithine Decarboxy | 1986 |
Polyamines as intermediates in developmental neurotoxic events.
Topics: Animals; Body Weight; Brain; Cell Division; DNA Replication; Eflornithine; Female; Organ Size; Ornit | 1986 |
Epidermal growth factor potentiates the induction of ornithine decarboxylase activity by prostaglandins in embryonic palate mesenchymal cells: effects on cell proliferation and glycosaminoglycan synthesis.
Topics: Animals; Cell Division; Cells, Cultured; Cycloheximide; Dactinomycin; Dinoprost; Dinoprostone; DNA R | 1987 |
Effect of D,L-alpha-difluoromethyl ornithine on cleft palate induced by the TCDD congener, 3,3',4,4'-tetrachloroazoxybenzene, in the fetuses of mice.
Topics: Animals; Azo Compounds; Chlorobenzenes; Cleft Palate; Eflornithine; Female; Fetal Death; Mice; Polyc | 1988 |