eflornithine has been researched along with Pituitary Neoplasms in 1 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the estradiol-responsive human breast cancer cell line, T-47D clone 11, estradiol (10(-10) M) was able to stimulate cell proliferation and the activity of ornithine decarboxylase (ODC), the first and rate-limiting enzyme in the biosynthesis of polyamines." | 3.67 | Intrinsic and extrinsic factors in estrogen action in human breast cancer: role of polyamines and pituitary factors. ( Dembinski, TC; Leung, CK; Lima, G; Shiu, RP, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shiu, RP | 1 |
| Lima, G | 1 |
| Leung, CK | 1 |
| Dembinski, TC | 1 |
1 other study available for eflornithine and Pituitary Neoplasms
| Article | Year |
|---|---|
Intrinsic and extrinsic factors in estrogen action in human breast cancer: role of polyamines and pituitary factors.
Topics: Animals; Breast Neoplasms; Cell Line; Drug Synergism; Eflornithine; Estrogens; Female; Humans; Mice; | 1986 |