eflornithine has been researched along with Pancreatic Neoplasms in 22 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we tested DFMO in combination with a polyamine transport inhibitor (PTI), Trimer44NMe, against Gemcitabine-resistant PDAC cells." | 1.48 | Difluoromethylornithine Combined with a Polyamine Transport Inhibitor Is Effective against Gemcitabine Resistant Pancreatic Cancer. ( Altomare, DA; Copik, AJ; Gitto, SB; Hogan, FC; Oyer, JL; Pandey, V; Phanstiel, O, 2018) |
| "Establishment of this human carcinoid xenograft line, BON, provides an excellent model to study further the biological behavior of carcinoid tumors and the in vivo effect of chemotherapeutic agents on tumor growth." | 1.28 | Establishment and characterization of a human carcinoid in nude mice and effect of various agents on tumor growth. ( Allen, E; Evers, BM; Hurlbut, SC; Kim, SW; Rajaraman, S; Reubi, JC; Singh, P; Thompson, JC; Townsend, CM; Upp, JR, 1991) |
| " On the basis of these prior findings, we investigated the effects of alpha-difluoromethylornithine (DFMO), a specific inhibitor of ornithine decarboxylase, alone and in combination with cis-diamminedichloroplatinum(II) (cisplatin), to which two of the four cell lines display relative resistance." | 1.27 | Inhibition of growth of human or hamster pancreatic cancer cell lines by alpha-difluoromethylornithine alone and combined with cis-diamminedichloroplatinum(II). ( Black, O; Chang, BK; Gutman, R, 1984) |
| "CsA had inhibitory effects on H2T pancreatic cancer growth similar to those of alpha-DFMO; these effects were blocked by the addition of the polyamine putrescine." | 1.27 | Effects of cyclosporin A and alpha-difluoromethylornithine on the growth of hamster pancreatic cancer in vitro. ( Barranco, SC; James, E; Saydjari, R; Thompson, JC; Townsend, CM, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (40.91) | 18.7374 |
| 1990's | 8 (36.36) | 18.2507 |
| 2000's | 1 (4.55) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Nakkina, SP | 1 |
| Gitto, SB | 2 |
| Beardsley, JM | 1 |
| Pandey, V | 2 |
| Rohr, MW | 1 |
| Parikh, JG | 1 |
| Phanstiel, O | 3 |
| Altomare, DA | 2 |
| Oyer, JL | 1 |
| Copik, AJ | 1 |
| Hogan, FC | 1 |
| Muth, A | 1 |
| Madan, M | 1 |
| Archer, JJ | 1 |
| Ocampo, N | 1 |
| Rodriguez, L | 1 |
| Mohammed, A | 1 |
| Janakiram, NB | 1 |
| Madka, V | 1 |
| Ritchie, RL | 1 |
| Brewer, M | 1 |
| Biddick, L | 1 |
| Patlolla, JM | 1 |
| Sadeghi, M | 1 |
| Lightfoot, S | 1 |
| Steele, VE | 1 |
| Rao, CV | 1 |
| Chang, BK | 4 |
| Black, O | 2 |
| Gutman, R | 3 |
| Sjöholm, A | 3 |
| Arkhammar, P | 1 |
| Welsh, N | 2 |
| Bokvist, K | 1 |
| Rorsman, P | 1 |
| Hallberg, A | 1 |
| Nilsson, T | 1 |
| Welsh, M | 1 |
| Berggren, PO | 1 |
| Honkanen, RE | 1 |
| Evers, BM | 2 |
| Hurlbut, SC | 2 |
| Tyring, SK | 1 |
| Townsend, CM | 8 |
| Uchida, T | 1 |
| Thompson, JC | 8 |
| Upp, JR | 2 |
| Allen, E | 1 |
| Kim, SW | 1 |
| Rajaraman, S | 1 |
| Singh, P | 1 |
| Reubi, JC | 1 |
| Camara, J | 1 |
| Galera, C | 1 |
| Valverde, I | 1 |
| Malaisse, WJ | 1 |
| Hoftiezer, V | 1 |
| Bankston, PW | 1 |
| Hellerström, C | 1 |
| Nicolet, T | 1 |
| Scemama, JL | 1 |
| Pradayrol, L | 1 |
| Berthélémy, P | 1 |
| Seva, C | 1 |
| Vaysse, N | 1 |
| Saydjari, R | 5 |
| Alexander, RW | 2 |
| Barranco, SC | 6 |
| James, E | 1 |
| Chou, TC | 1 |
| Marx, M | 1 |
| Glass, EJ | 1 |
| Malt, RA | 1 |
| Kingsnorth, AN | 1 |
| Lamuraglia, GM | 1 |
| Lacaine, F | 1 |
| Ross, JS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563] | Phase 2 | 70 participants (Anticipated) | Interventional | 2023-03-14 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for eflornithine and Pancreatic Neoplasms
| Article | Year |
|---|---|
Chemoprevention and chemotherapy by inhibition of ornithine decarboxylase activity and polyamine synthesis: colonic, pancreatic, mammary, and renal carcinomas.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Division; Colonic Neoplasms; Eflornithine; Fe | 1985 |
21 other studies available for eflornithine and Pancreatic Neoplasms
| Article | Year |
|---|---|
DFMO Improves Survival and Increases Immune Cell Infiltration in Association with MYC Downregulation in the Pancreatic Tumor Microenvironment.
Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Cell Survival; Down-Reg | 2021 |
Difluoromethylornithine Combined with a Polyamine Transport Inhibitor Is Effective against Gemcitabine Resistant Pancreatic Cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biological Transport; Biosynthet | 2018 |
Polyamine transport inhibitors: design, synthesis, and combination therapies with difluoromethylornithine.
Topics: Animals; Antineoplastic Agents; Benzene Derivatives; Biological Transport; Cell Line, Tumor; CHO Cel | 2014 |
Eflornithine (DFMO) prevents progression of pancreatic cancer by modulating ornithine decarboxylase signaling.
Topics: Animals; Apoptosis; Blotting, Western; Carcinoma, Pancreatic Ductal; Cell Proliferation; Disease Pro | 2014 |
Inhibition of growth of human or hamster pancreatic cancer cell lines by alpha-difluoromethylornithine alone and combined with cis-diamminedichloroplatinum(II).
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Cell Survival; Cisplatin; Cricetinae; Drug | 1984 |
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Ne | 1993 |
Polyamines regulate serine/threonine protein phosphatases in insulin-secreting cells.
Topics: Arginine; Eflornithine; Enzyme Activation; Enzyme Inhibitors; Histones; Humans; Insulin; Insulin Sec | 2000 |
Novel therapy for the treatment of human carcinoid.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carcinoid Tumor; Cell Line; Di | 1991 |
Establishment and characterization of a human carcinoid in nude mice and effect of various agents on tumor growth.
Topics: Animals; Binding Sites; Carcinoid Tumor; Cell Division; Cell Line; DNA; Eflornithine; Gastrins; Huma | 1991 |
Inhibitory effects of a calcium antagonist on ornithine decarboxylase induction in pancreatic cancer cell lines.
Topics: Animals; Calcium; Eflornithine; Enzyme Induction; Ornithine Decarboxylase; Ornithine Decarboxylase I | 1991 |
Relationship between D-glucose oxidation and glycolysis in tumoral pancreatic islet cells with either rapid or decreased cell growth.
Topics: Animals; Carbon Dioxide; Carbon Radioisotopes; Cell Division; Cell Line; Citric Acid Cycle; Eflornit | 1991 |
Increased glucose oxidation and contents of insulin and ATP in polyamine-depleted rat insulinoma cells (RINm5F).
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Line; Cytoplasmic Granules; Eflornithin | 1991 |
Putrescine and spermidine uptake is regulated by proliferation and dexamethasone treatment in AR4-2J cells.
Topics: Animals; Biological Transport; Cell Division; Cell Line; Cells, Cultured; Dexamethasone; Eflornithin | 1991 |
Differential sensitivity of various human tumors to inhibition of polyamine biosynthesis in vivo.
Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Eflornithine; Humans; Mice; Mice, Inbred BALB | 1991 |
The effects of 2-deoxy-D-glucose and alpha-difluoromethylornithine on the growth of pancreatic cancer in vivo.
Topics: Animals; Cell Division; Cricetinae; Deoxy Sugars; Deoxyglucose; Eflornithine; Male; Mesocricetus; Pa | 1989 |
Effects of cyclosporin A and alpha-difluoromethylornithine on the growth of hamster pancreatic cancer in vitro.
Topics: Animals; Carcinoma, Intraductal, Noninfiltrating; Cell Cycle; Cell Line; Cell Survival; Cricetinae; | 1986 |
Schedule-dependent interaction of alpha-difluoromethylornithine and cis-diamminedichloroplatinum(II) against human and hamster pancreatic cancer cell lines.
Topics: Adenocarcinoma; Animals; Cell Line; Cisplatin; Colony-Forming Units Assay; Cricetinae; Drug Synergis | 1987 |
Combined effects of alpha-difluoromethylornithine and doxorubicin against pancreatic cancer cell lines in culture.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Doxorubicin; Dru | 1986 |
Treatment of hamster pancreatic cancer with alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis.
Topics: Adenocarcinoma; Animals; Body Weight; Cricetinae; Depression, Chemical; Eflornithine; Male; Mesocric | 1987 |
Cyclosporine and alpha-difluoromethylornithine exhibit differential effects on colon and pancreatic cancer in vitro.
Topics: Animals; Colonic Neoplasms; Cyclosporins; Dose-Response Relationship, Drug; Eflornithine; Humans; Mi | 1987 |
Differential sensitivity of pancreatic and colon cancer to cyclosporine and alpha-difluoromethylornithine in vivo.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Cricetinae; Cyclosporins; Eflornithine; Mesocricetus; Mi | 1988 |