eflornithine has been researched along with Ovarian Neoplasms in 5 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "However, ovarian cancers often reacquire functional BRCA and develop resistance to PARP inhibitors." | 1.72 | Difluoromethylornithine (DFMO) Enhances the Cytotoxicity of PARP Inhibition in Ovarian Cancer Cells. ( Doyle, B; El Naggar, O; Gilmour, SK; Mariner, K, 2022) |
| "Difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), has promising activity against various cancers and a tolerable safety profile for long-term use as a chemopreventive agent." | 1.62 | Difluoromethylornithine Induces Apoptosis through Regulation of AP-1 Signaling via JNK Phosphorylation in Epithelial Ovarian Cancer. ( Hwang, WY; Kim, K; Kim, YB; No, JH; Park, WH; Suh, DH, 2021) |
| "Although ovarian cancer has a low incidence rate, it remains the most deadly gynecologic malignancy." | 1.51 | DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer. ( Bachman, KE; Baylin, SB; Brown, SM; Casero, RA; Dunworth, M; Foley, JR; Holbert, CE; Stone, ML; Travers, M; Wiehagen, KR; Zahnow, CA, 2019) |
| "The antiproliferative effects of human recombinant interferon gamma (IFN gamma) in combination with alpha-difluoromethylornithine (DFMO) or as single agents were assessed on human cell cultures derived from carcinomas of the breast (MCF-7), the ovary (EFO-27) or the kidneys (EGI-4)." | 1.29 | Antiproliferative effects of interferon gamma in combination with alpha-difluoromethylornithine on human carcinoma cell cultures. ( Hölzel, F; Kirchner, H; Klouche, M, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hwang, WY | 1 |
| Park, WH | 1 |
| Suh, DH | 1 |
| Kim, K | 1 |
| Kim, YB | 1 |
| No, JH | 1 |
| El Naggar, O | 1 |
| Doyle, B | 1 |
| Mariner, K | 1 |
| Gilmour, SK | 1 |
| Travers, M | 1 |
| Brown, SM | 1 |
| Dunworth, M | 1 |
| Holbert, CE | 1 |
| Wiehagen, KR | 1 |
| Bachman, KE | 1 |
| Foley, JR | 1 |
| Stone, ML | 1 |
| Baylin, SB | 1 |
| Casero, RA | 1 |
| Zahnow, CA | 1 |
| Klouche, M | 1 |
| Kirchner, H | 1 |
| Hölzel, F | 1 |
| Manetta, A | 1 |
| Satyaswarcoop, PG | 1 |
| Podczaski, ES | 1 |
| Hamilton, T | 1 |
| Ozols, RF | 1 |
| Mortel, R | 1 |
5 other studies available for eflornithine and Ovarian Neoplasms
| Article | Year |
|---|---|
Difluoromethylornithine Induces Apoptosis through Regulation of AP-1 Signaling via JNK Phosphorylation in Epithelial Ovarian Cancer.
Topics: Apoptosis; bcl-2-Associated X Protein; Carcinoma, Ovarian Epithelial; Caspase 3; Cell Line, Tumor; C | 2021 |
Difluoromethylornithine (DFMO) Enhances the Cytotoxicity of PARP Inhibition in Ovarian Cancer Cells.
Topics: Antineoplastic Agents; Eflornithine; Female; Humans; Ovarian Neoplasms; Poly(ADP-ribose) Polymerase | 2022 |
DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cystadenocarcinoma, Serous; Di | 2019 |
Antiproliferative effects of interferon gamma in combination with alpha-difluoromethylornithine on human carcinoma cell cultures.
Topics: Breast Neoplasms; Cell Division; Drug Synergism; Eflornithine; Female; Growth Inhibitors; Humans; In | 1994 |
Effect of alpha-difluoromethylornithine (DFMO) on the growth of human ovarian carcinoma.
Topics: Animals; Eflornithine; Female; Humans; In Vitro Techniques; Mice; Mice, Nude; Ovarian Neoplasms; Tum | 1988 |