eflornithine has been researched along with Multiple Myeloma in 9 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We have now employed the PCR combined with reverse transcription to determine semiquantitatively ODC gene dosage and the amounts of heterogeneous nuclear (hn) RNA and of mature mRNA of the enzyme in parental and alpha-difluoromethylornithine-resistant human myeloma cells." | 1.28 | Levels of ornithine decarboxylase genomic sequences, heterogeneous nuclear RNA and mRNA in human myeloma cells resistant to alpha-difluoromethylornithine. ( Alhonen, L; Halmekytö, M; Hyttinen, IM; Jänne, J, 1991) |
| "When putrescine was combined concurrently with VP-16, both the in vitro cytotoxic effects and the number of DNA SSBs in L1210 cells were significantly reduced." | 1.27 | Modulation of etoposide cytotoxicity and DNA strand scission in L1210 and 8226 cells by polyamines. ( Dorr, RT; Gerner, EW; Liddil, JD, 1986) |
| " Restriction enzyme analyses of genomic DNA isolated from the resistant cells indicated that the gene dosage for ornithine decarboxylase was not increased to any appreciable extent." | 1.27 | Human myeloma cells acquire resistance to difluoromethylornithine without overproducing ornithine decarboxylase. ( Alhonen-Hongisto, L; Jänne, J; Laine, R; Leinonen, P, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (77.78) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wahlfors, J | 1 |
| Myöhänen, S | 1 |
| Korhonen, VP | 1 |
| Alhonen, L | 2 |
| Jänne, J | 4 |
| Hyttinen, IM | 1 |
| Halmekytö, M | 1 |
| Katz, A | 1 |
| Kahana, C | 2 |
| Dorr, RT | 1 |
| Liddil, JD | 1 |
| Gerner, EW | 1 |
| Alhonen-Hongisto, L | 2 |
| Leinonen, P | 2 |
| Laine, R | 2 |
| Jänne, OA | 1 |
| Maddox, AM | 2 |
| Freireich, EJ | 2 |
| Keating, MJ | 2 |
| Frasier-Scott, KF | 1 |
| Haddox, MK | 2 |
| Nathans, D | 1 |
9 other studies available for eflornithine and Multiple Myeloma
| Article | Year |
|---|---|
Long-term reduction of amplified ornithine decarboxylase sequences in human myeloma cells.
Topics: Animals; Eflornithine; Gene Amplification; Humans; Mice; Mice, Transgenic; Multiple Myeloma; Ornithi | 1995 |
Levels of ornithine decarboxylase genomic sequences, heterogeneous nuclear RNA and mRNA in human myeloma cells resistant to alpha-difluoromethylornithine.
Topics: Base Sequence; Cell Line; Drug Resistance; Eflornithine; Humans; Molecular Sequence Data; Multiple M | 1991 |
Rearrangement between ornithine decarboxylase and the switch region of the gamma 1 immunoglobulin gene in alpha-difluoromethylornithine resistant mouse myeloma cells.
Topics: Animals; Base Sequence; DNA; Drug Resistance; Eflornithine; Gene Amplification; Gene Rearrangement; | 1989 |
Modulation of etoposide cytotoxicity and DNA strand scission in L1210 and 8226 cells by polyamines.
Topics: Animals; Cell Survival; DNA Topoisomerases, Type II; DNA, Neoplasm; DNA, Single-Stranded; Eflornithi | 1986 |
Human myeloma cells acquire resistance to difluoromethylornithine without overproducing ornithine decarboxylase.
Topics: Arginase; Cell Division; Cell Line; Drug Resistance; Eflornithine; Humans; Multiple Myeloma; Ornithi | 1987 |
Human myeloma cells acquire resistance to difluoromethylornithine by amplification of ornithine decarboxylase gene.
Topics: Cell Line; Chemical Precipitation; Drug Resistance; Eflornithine; Gene Amplification; Genotype; Huma | 1987 |
Alterations in human circulating and bone marrow mononuclear cell polyamine levels in hematologic malignancies as a consequence of difluoromethylornithine administration.
Topics: Adolescent; Adult; Aged; Biogenic Polyamines; Bone Marrow; Eflornithine; Female; Humans; Leukemia; L | 1988 |
Polyamines increase in human peripheral blood and bone marrow mononuclear cells following administration of methylglyoxal bis(guanylhydrazone).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biogenic Polyamines; Bone Marrow; Drug | 1988 |
Translational regulation of mammalian ornithine decarboxylase by polyamines.
Topics: Animals; Cell Line; Drug Resistance; Eflornithine; Mice; Multiple Myeloma; Ornithine; Ornithine Deca | 1985 |