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eflornithine and Metastase

eflornithine has been researched along with Metastase in 16 studies

Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.

Research Excerpts

ExcerptRelevanceReference
"alpha-Difluoromethylornithine (DFMO) and methylglyoxal bis-(guanylhydrazone) (MGBG) were tested against a murine renal adenocarcinoma, because polyamines are necessary for neoplastic cell growth and because human renal adenocarcinomas contain higher levels of spermidine than do normal renal cells; MGBG inhibits spermidine synthesis and has some activity against human renal tumors; DFMO irreversibly inhibits ornithine decarboxylase, the first rate-limiting enzyme controlling polyamine biosynthesis; and DFMO promotes intracellular accumulation of MGBG in experimental tumor models and human leukemia."7.67Effects of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the growth of experimental renal adenocarcinoma in mice. ( Burchenal, JH; Conti, PS; Herr, HW; Kleinert, EL; Whitmore, WF, 1984)
"The depletion of polyamines by alpha-difluoromethylornithine (DFMO) treatment of mice after subcutaneous inoculation of adenocarcinoma M3 cells caused a remarkable inhibition in the growth rate of primary tumors as well as in the occurrence and number of lung metastases with a concomitant increase in survival time."7.67Effect of alpha-difluoromethylornithine in lung metastases before and after surgery of primary adenocarcinoma tumors in mice. ( Algranati, ID; de Lustig, ES; Klein, S; Miret, JJ, 1985)
" Experiments were carried out on the trastuzumab-resistant human epidermal growth factor receptor 2-overexpressing breast cancer cell line JIMT-1 to unravel the chemotherapeutic effects of the polyamine analogue [1N,12N]bis(ethyl)-cis-6,7-dehydrospermine (PG11047) and of the polyamine biosynthetic inhibitor 2-difluoromethylornithine (DFMO) on the CD44+CD24- CSC population."3.76Reduction of the putative CD44+CD24- breast cancer stem cell population by targeting the polyamine metabolic pathway with PG11047. ( Cirenajwis, H; Hegardt, C; Honeth, G; Marton, LJ; Oredsson, SM; Smiljanic, S, 2010)
"alpha-Difluoromethylornithine (DFMO) and methylglyoxal bis-(guanylhydrazone) (MGBG) were tested against a murine renal adenocarcinoma, because polyamines are necessary for neoplastic cell growth and because human renal adenocarcinomas contain higher levels of spermidine than do normal renal cells; MGBG inhibits spermidine synthesis and has some activity against human renal tumors; DFMO irreversibly inhibits ornithine decarboxylase, the first rate-limiting enzyme controlling polyamine biosynthesis; and DFMO promotes intracellular accumulation of MGBG in experimental tumor models and human leukemia."3.67Effects of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the growth of experimental renal adenocarcinoma in mice. ( Burchenal, JH; Conti, PS; Herr, HW; Kleinert, EL; Whitmore, WF, 1984)
"The depletion of polyamines by alpha-difluoromethylornithine (DFMO) treatment of mice after subcutaneous inoculation of adenocarcinoma M3 cells caused a remarkable inhibition in the growth rate of primary tumors as well as in the occurrence and number of lung metastases with a concomitant increase in survival time."3.67Effect of alpha-difluoromethylornithine in lung metastases before and after surgery of primary adenocarcinoma tumors in mice. ( Algranati, ID; de Lustig, ES; Klein, S; Miret, JJ, 1985)
"DFMO did not affect pulmonary metastasis when primary tumors of control and DFMO-treated mice were matched for size."1.35Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells. ( Bruggeman, R; Demers, LM; Griffith, JW; Jun, JY; Manni, A; Verderame, MF; Washington, S, 2008)
"DFMO did not affect pulmonary metastasis when primary tumors of control and DFMO-treated mice were matched for size."1.34Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells. ( Bruggeman, R; Demers, LM; Griffith, JW; Jun, JY; Manni, A; Verderame, MF; Washington, S, 2007)
"The number and incidence of lung metastases were determined."1.33Metastasis of hormone-independent breast cancer to lung and bone is decreased by alpha-difluoromethylornithine treatment. ( Bond, JS; Demers, LM; DiGirolamo, DJ; Manni, A; Matters, G; Phadke, PA; Richert, MM; Washington, S; Welch, DR, 2005)
"In a mouse model of experimental metastasis, DFMO provided in the water supply also dramatically diminished seeding and growth of tumor foci in the lungs by heparan sulfate-deficient mutant cells compared with the controls."1.31Tumor attenuation by combined heparan sulfate and polyamine depletion. ( Belting, M; Borsig, L; Brown, JR; Esko, JD; Fransson, LA; Fuster, MM; Persson, L, 2002)
"The formation of lung metastases was prevented by 70 to 100%, depending on the treatment."1.28Endogenous and exogenous polyamines in support of tumor growth. ( Grauffel, C; Jones, R; Knödgen, B; Moulinoux, JP; Sarhan, S; Seiler, N, 1990)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19908 (50.00)18.7374
1990's1 (6.25)18.2507
2000's6 (37.50)29.6817
2010's1 (6.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cirenajwis, H1
Smiljanic, S1
Honeth, G1
Hegardt, C1
Marton, LJ1
Oredsson, SM1
Manni, A4
Washington, S4
Hu, X1
Griffith, JW3
Bruggeman, R3
Demers, LM4
Mauger, D1
Verderame, MF3
Richert, MM1
Phadke, PA1
Matters, G1
DiGirolamo, DJ1
Bond, JS1
Welch, DR1
Jun, JY2
Herr, HW1
Kleinert, EL1
Conti, PS1
Burchenal, JH1
Whitmore, WF1
Sunkara, PS2
Prakash, NJ1
Rosenberger, AL2
Belting, M1
Borsig, L1
Fuster, MM1
Brown, JR1
Persson, L1
Fransson, LA1
Esko, JD1
Donald, CD1
Cooper, CR1
Harris-Hooker, S1
Emmett, N1
Scanlon, M1
Cooke, DB1
Seiler, N1
Sarhan, S1
Grauffel, C1
Jones, R1
Knödgen, B1
Moulinoux, JP1
Dunzendorfer, U1
Knöner, M1
de Lustig, ES2
Klein, S2
Fuchs, A1
Algranati, ID2
Meyskens, FL1
Kingsley, EM1
Glattke, T1
Loescher, L1
Booth, A1
Nakaike, S1
Kashiwagi, K1
Terao, K1
Iio, K1
Igarashi, K1
Miret, JJ1

Other Studies

16 other studies available for eflornithine and Metastase

ArticleYear
Reduction of the putative CD44+CD24- breast cancer stem cell population by targeting the polyamine metabolic pathway with PG11047.
    Anti-cancer drugs, 2010, Volume: 21, Issue:10

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms;

2010
Effects of polyamine synthesis inhibitors on primary tumor features and metastatic capacity of human breast cancer cells.
    Clinical & experimental metastasis, 2005, Volume: 22, Issue:3

    Topics: Amidines; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cell Proli

2005
Metastasis of hormone-independent breast cancer to lung and bone is decreased by alpha-difluoromethylornithine treatment.
    Breast cancer research : BCR, 2005, Volume: 7, Issue:5

    Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Eflornithine; Fe

2005
Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells.
    Breast cancer research and treatment, 2007, Volume: 105, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Collagen; Drug Combinations; Eflornithi

2007
Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells.
    Breast cancer research and treatment, 2008, Volume: 107, Issue:1

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Eflornithine; Extracellular Signal-Regulated MAP Kina

2008
Effects of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the growth of experimental renal adenocarcinoma in mice.
    Cancer research, 1984, Volume: 44, Issue:10

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Body Weight; Cell Division; Drug Synergism; Eflornit

1984
An essential role for polyamines in tumor metastases.
    FEBS letters, 1982, Dec-27, Volume: 150, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Division; Eflornithine; Lung Neoplasms; Mice; Mice, Inbred C57B

1982
Tumor attenuation by combined heparan sulfate and polyamine depletion.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Jan-08, Volume: 99, Issue:1

    Topics: Animals; Antineoplastic Agents; CHO Cells; Cricetinae; DNA, Complementary; Dose-Response Relationshi

2002
Cytoskeletal organization and cell motility correlates with metastatic potential and state of differentiation in prostate cancer.
    Cellular and molecular biology (Noisy-le-Grand, France), 2001, Volume: 47, Issue:6

    Topics: Actins; Adenocarcinoma; Animals; Antineoplastic Agents; Cell Differentiation; Cell Movement; Cytoske

2001
Endogenous and exogenous polyamines in support of tumor growth.
    Cancer research, 1990, Aug-15, Volume: 50, Issue:16

    Topics: Animals; Antineoplastic Agents; Cell Division; Eflornithine; Female; Leukocyte Count; Lung Neoplasms

1990
[Therapy with inhibitors of polyamine biosynthesis in refractory prostatic carcinoma. An experimental and clinical study].
    Onkologie, 1985, Volume: 8, Issue:4

    Topics: Adenocarcinoma; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Carboxy-Lyases; Ca

1985
Long-term treatment of tumor-operated mice with high doses of alpha-difluoromethylornithine.
    Biology of the cell, 1986, Volume: 58, Issue:3

    Topics: Adenocarcinoma; Animals; Bone Marrow; Combined Modality Therapy; Eflornithine; Female; Mammary Neopl

1986
Antimetastatic activity of DL-alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis, in mice.
    Cancer research, 1987, Feb-15, Volume: 47, Issue:4

    Topics: Animals; Eflornithine; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neop

1987
A phase II study of alpha-difluoromethylornithine (DFMO) for the treatment of metastatic melanoma.
    Investigational new drugs, 1986, Volume: 4, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents; Drug Evaluation; Eflornithine; Female; Hearing; Humans; Male; Me

1986
Combined use of alpha-difluoromethylornithine and an inhibitor of S-adenosylmethionine decarboxylase in mice bearing P388 leukemia or Lewis lung carcinoma.
    Japanese journal of cancer research : Gann, 1988, Volume: 79, Issue:4

    Topics: Adenosylmethionine Decarboxylase; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined

1988
Effect of alpha-difluoromethylornithine in lung metastases before and after surgery of primary adenocarcinoma tumors in mice.
    Biology of the cell, 1985, Volume: 53, Issue:1

    Topics: Adenocarcinoma; Animals; Eflornithine; Lung; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice;

1985