eflornithine has been researched along with Metastase in 16 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "alpha-Difluoromethylornithine (DFMO) and methylglyoxal bis-(guanylhydrazone) (MGBG) were tested against a murine renal adenocarcinoma, because polyamines are necessary for neoplastic cell growth and because human renal adenocarcinomas contain higher levels of spermidine than do normal renal cells; MGBG inhibits spermidine synthesis and has some activity against human renal tumors; DFMO irreversibly inhibits ornithine decarboxylase, the first rate-limiting enzyme controlling polyamine biosynthesis; and DFMO promotes intracellular accumulation of MGBG in experimental tumor models and human leukemia." | 7.67 | Effects of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the growth of experimental renal adenocarcinoma in mice. ( Burchenal, JH; Conti, PS; Herr, HW; Kleinert, EL; Whitmore, WF, 1984) |
| "The depletion of polyamines by alpha-difluoromethylornithine (DFMO) treatment of mice after subcutaneous inoculation of adenocarcinoma M3 cells caused a remarkable inhibition in the growth rate of primary tumors as well as in the occurrence and number of lung metastases with a concomitant increase in survival time." | 7.67 | Effect of alpha-difluoromethylornithine in lung metastases before and after surgery of primary adenocarcinoma tumors in mice. ( Algranati, ID; de Lustig, ES; Klein, S; Miret, JJ, 1985) |
| " Experiments were carried out on the trastuzumab-resistant human epidermal growth factor receptor 2-overexpressing breast cancer cell line JIMT-1 to unravel the chemotherapeutic effects of the polyamine analogue [1N,12N]bis(ethyl)-cis-6,7-dehydrospermine (PG11047) and of the polyamine biosynthetic inhibitor 2-difluoromethylornithine (DFMO) on the CD44+CD24- CSC population." | 3.76 | Reduction of the putative CD44+CD24- breast cancer stem cell population by targeting the polyamine metabolic pathway with PG11047. ( Cirenajwis, H; Hegardt, C; Honeth, G; Marton, LJ; Oredsson, SM; Smiljanic, S, 2010) |
| "alpha-Difluoromethylornithine (DFMO) and methylglyoxal bis-(guanylhydrazone) (MGBG) were tested against a murine renal adenocarcinoma, because polyamines are necessary for neoplastic cell growth and because human renal adenocarcinomas contain higher levels of spermidine than do normal renal cells; MGBG inhibits spermidine synthesis and has some activity against human renal tumors; DFMO irreversibly inhibits ornithine decarboxylase, the first rate-limiting enzyme controlling polyamine biosynthesis; and DFMO promotes intracellular accumulation of MGBG in experimental tumor models and human leukemia." | 3.67 | Effects of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the growth of experimental renal adenocarcinoma in mice. ( Burchenal, JH; Conti, PS; Herr, HW; Kleinert, EL; Whitmore, WF, 1984) |
| "The depletion of polyamines by alpha-difluoromethylornithine (DFMO) treatment of mice after subcutaneous inoculation of adenocarcinoma M3 cells caused a remarkable inhibition in the growth rate of primary tumors as well as in the occurrence and number of lung metastases with a concomitant increase in survival time." | 3.67 | Effect of alpha-difluoromethylornithine in lung metastases before and after surgery of primary adenocarcinoma tumors in mice. ( Algranati, ID; de Lustig, ES; Klein, S; Miret, JJ, 1985) |
| "DFMO did not affect pulmonary metastasis when primary tumors of control and DFMO-treated mice were matched for size." | 1.35 | Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells. ( Bruggeman, R; Demers, LM; Griffith, JW; Jun, JY; Manni, A; Verderame, MF; Washington, S, 2008) |
| "DFMO did not affect pulmonary metastasis when primary tumors of control and DFMO-treated mice were matched for size." | 1.34 | Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells. ( Bruggeman, R; Demers, LM; Griffith, JW; Jun, JY; Manni, A; Verderame, MF; Washington, S, 2007) |
| "The number and incidence of lung metastases were determined." | 1.33 | Metastasis of hormone-independent breast cancer to lung and bone is decreased by alpha-difluoromethylornithine treatment. ( Bond, JS; Demers, LM; DiGirolamo, DJ; Manni, A; Matters, G; Phadke, PA; Richert, MM; Washington, S; Welch, DR, 2005) |
| "In a mouse model of experimental metastasis, DFMO provided in the water supply also dramatically diminished seeding and growth of tumor foci in the lungs by heparan sulfate-deficient mutant cells compared with the controls." | 1.31 | Tumor attenuation by combined heparan sulfate and polyamine depletion. ( Belting, M; Borsig, L; Brown, JR; Esko, JD; Fransson, LA; Fuster, MM; Persson, L, 2002) |
| "The formation of lung metastases was prevented by 70 to 100%, depending on the treatment." | 1.28 | Endogenous and exogenous polyamines in support of tumor growth. ( Grauffel, C; Jones, R; Knödgen, B; Moulinoux, JP; Sarhan, S; Seiler, N, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (50.00) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 6 (37.50) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cirenajwis, H | 1 |
| Smiljanic, S | 1 |
| Honeth, G | 1 |
| Hegardt, C | 1 |
| Marton, LJ | 1 |
| Oredsson, SM | 1 |
| Manni, A | 4 |
| Washington, S | 4 |
| Hu, X | 1 |
| Griffith, JW | 3 |
| Bruggeman, R | 3 |
| Demers, LM | 4 |
| Mauger, D | 1 |
| Verderame, MF | 3 |
| Richert, MM | 1 |
| Phadke, PA | 1 |
| Matters, G | 1 |
| DiGirolamo, DJ | 1 |
| Bond, JS | 1 |
| Welch, DR | 1 |
| Jun, JY | 2 |
| Herr, HW | 1 |
| Kleinert, EL | 1 |
| Conti, PS | 1 |
| Burchenal, JH | 1 |
| Whitmore, WF | 1 |
| Sunkara, PS | 2 |
| Prakash, NJ | 1 |
| Rosenberger, AL | 2 |
| Belting, M | 1 |
| Borsig, L | 1 |
| Fuster, MM | 1 |
| Brown, JR | 1 |
| Persson, L | 1 |
| Fransson, LA | 1 |
| Esko, JD | 1 |
| Donald, CD | 1 |
| Cooper, CR | 1 |
| Harris-Hooker, S | 1 |
| Emmett, N | 1 |
| Scanlon, M | 1 |
| Cooke, DB | 1 |
| Seiler, N | 1 |
| Sarhan, S | 1 |
| Grauffel, C | 1 |
| Jones, R | 1 |
| Knödgen, B | 1 |
| Moulinoux, JP | 1 |
| Dunzendorfer, U | 1 |
| Knöner, M | 1 |
| de Lustig, ES | 2 |
| Klein, S | 2 |
| Fuchs, A | 1 |
| Algranati, ID | 2 |
| Meyskens, FL | 1 |
| Kingsley, EM | 1 |
| Glattke, T | 1 |
| Loescher, L | 1 |
| Booth, A | 1 |
| Nakaike, S | 1 |
| Kashiwagi, K | 1 |
| Terao, K | 1 |
| Iio, K | 1 |
| Igarashi, K | 1 |
| Miret, JJ | 1 |
16 other studies available for eflornithine and Metastase
| Article | Year |
|---|---|
Reduction of the putative CD44+CD24- breast cancer stem cell population by targeting the polyamine metabolic pathway with PG11047.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; | 2010 |
Effects of polyamine synthesis inhibitors on primary tumor features and metastatic capacity of human breast cancer cells.
Topics: Amidines; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cell Proli | 2005 |
Metastasis of hormone-independent breast cancer to lung and bone is decreased by alpha-difluoromethylornithine treatment.
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Eflornithine; Fe | 2005 |
Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Collagen; Drug Combinations; Eflornithi | 2007 |
Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Eflornithine; Extracellular Signal-Regulated MAP Kina | 2008 |
Effects of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the growth of experimental renal adenocarcinoma in mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Body Weight; Cell Division; Drug Synergism; Eflornit | 1984 |
An essential role for polyamines in tumor metastases.
Topics: Animals; Antineoplastic Agents; Cell Division; Eflornithine; Lung Neoplasms; Mice; Mice, Inbred C57B | 1982 |
Tumor attenuation by combined heparan sulfate and polyamine depletion.
Topics: Animals; Antineoplastic Agents; CHO Cells; Cricetinae; DNA, Complementary; Dose-Response Relationshi | 2002 |
Cytoskeletal organization and cell motility correlates with metastatic potential and state of differentiation in prostate cancer.
Topics: Actins; Adenocarcinoma; Animals; Antineoplastic Agents; Cell Differentiation; Cell Movement; Cytoske | 2001 |
Endogenous and exogenous polyamines in support of tumor growth.
Topics: Animals; Antineoplastic Agents; Cell Division; Eflornithine; Female; Leukocyte Count; Lung Neoplasms | 1990 |
[Therapy with inhibitors of polyamine biosynthesis in refractory prostatic carcinoma. An experimental and clinical study].
Topics: Adenocarcinoma; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Carboxy-Lyases; Ca | 1985 |
Long-term treatment of tumor-operated mice with high doses of alpha-difluoromethylornithine.
Topics: Adenocarcinoma; Animals; Bone Marrow; Combined Modality Therapy; Eflornithine; Female; Mammary Neopl | 1986 |
Antimetastatic activity of DL-alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis, in mice.
Topics: Animals; Eflornithine; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neop | 1987 |
A phase II study of alpha-difluoromethylornithine (DFMO) for the treatment of metastatic melanoma.
Topics: Adult; Aged; Antineoplastic Agents; Drug Evaluation; Eflornithine; Female; Hearing; Humans; Male; Me | 1986 |
Combined use of alpha-difluoromethylornithine and an inhibitor of S-adenosylmethionine decarboxylase in mice bearing P388 leukemia or Lewis lung carcinoma.
Topics: Adenosylmethionine Decarboxylase; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined | 1988 |
Effect of alpha-difluoromethylornithine in lung metastases before and after surgery of primary adenocarcinoma tumors in mice.
Topics: Adenocarcinoma; Animals; Eflornithine; Lung; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; | 1985 |