eflornithine has been researched along with Malaria in 11 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study the antimalarial effect of agmatine (Agm) on chloroquine-susceptible Plasmodium berghei K173 strain (S strain) and the P berghei K173 resistant strain (R strain)." | 7.72 | Antimalarial effect of agmatine on Plasmodium berghei K173 strain. ( Li, J; Liu, Y; Su, RB; Wei, XL, 2003) |
| "A number of bis(benzyl)polyamine analogs were found to be potent inhibitors of both chloroquine-resistant and chloroquine-sensitive strains of the human malaria parasite Plasmodium falciparum in vitro (IC50 values = 0." | 7.67 | Bis(benzyl)polyamine analogs inhibit the growth of chloroquine-resistant human malaria parasites (Plasmodium falciparum) in vitro and in combination with alpha-difluoromethylornithine cure murine malaria. ( Bitonti, AJ; Bush, TL; Dumont, JA; Edwards, ML; McCann, PP; Sjoerdsma, A; Stemerick, DM, 1989) |
| "To study the antimalarial effect of agmatine (Agm) on chloroquine-susceptible Plasmodium berghei K173 strain (S strain) and the P berghei K173 resistant strain (R strain)." | 3.72 | Antimalarial effect of agmatine on Plasmodium berghei K173 strain. ( Li, J; Liu, Y; Su, RB; Wei, XL, 2003) |
| " A remarkable increase in polyamine content, and in the activity of ornithine and S-adenosyl-L-methionine decarboxylases, is noted in synchronous cultures of the malarial parasite, Plasmodium falciparum." | 3.67 | Polyamine levels and the activity of their biosynthetic enzymes in human erythrocytes infected with the malarial parasite, Plasmodium falciparum. ( Assaraf, YG; Bachrach, U; Golenser, J; Spira, DT, 1984) |
| "A number of bis(benzyl)polyamine analogs were found to be potent inhibitors of both chloroquine-resistant and chloroquine-sensitive strains of the human malaria parasite Plasmodium falciparum in vitro (IC50 values = 0." | 3.67 | Bis(benzyl)polyamine analogs inhibit the growth of chloroquine-resistant human malaria parasites (Plasmodium falciparum) in vitro and in combination with alpha-difluoromethylornithine cure murine malaria. ( Bitonti, AJ; Bush, TL; Dumont, JA; Edwards, ML; McCann, PP; Sjoerdsma, A; Stemerick, DM, 1989) |
| " The antimalarial drug, primaquine, the side chain of which is structurally analogous to a natural polyamine, did not enhance the activity of alpha-difluoromethylornithine or alpha-monofluoromethyldehydroornithine methyl ester." | 3.67 | Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony. ( Hollingdale, MR; McCann, PP; Sjoerdsma, A, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (63.64) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Su, RB | 1 |
| Wei, XL | 1 |
| Liu, Y | 1 |
| Li, J | 1 |
| Balasegaram, M | 1 |
| Dejene, S | 1 |
| Tinnemann, P | 1 |
| Perkins, S | 1 |
| Davidson, R | 1 |
| Müller, IB | 1 |
| Das Gupta, R | 1 |
| Lüersen, K | 1 |
| Wrenger, C | 1 |
| Walter, RD | 1 |
| Assaraf, YG | 1 |
| Golenser, J | 1 |
| Spira, DT | 1 |
| Bachrach, U | 1 |
| Gillet, JM | 1 |
| Boné, G | 2 |
| Herman, F | 1 |
| François, G | 1 |
| Van Looveren, M | 1 |
| Timperman, G | 1 |
| Bitonti, AJ | 2 |
| Dumont, JA | 1 |
| Bush, TL | 1 |
| Edwards, ML | 1 |
| Stemerick, DM | 1 |
| McCann, PP | 3 |
| Sjoerdsma, A | 3 |
| Whaun, JM | 1 |
| Brown, ND | 1 |
| Hollingdale, MR | 1 |
| Gillet, J | 1 |
| Lowa, P | 1 |
| Charlier, J | 1 |
| Rona, AM | 1 |
| Schechter, PJ | 1 |
1 review available for eflornithine and Malaria
| Article | Year |
|---|---|
Assessing the polyamine metabolism of Plasmodium falciparum as chemotherapeutic target.
Topics: Adenosylmethionine Decarboxylase; Animals; Antimalarials; Eflornithine; Malaria; Mice; Ornithine Dec | 2008 |
10 other studies available for eflornithine and Malaria
| Article | Year |
|---|---|
Antimalarial effect of agmatine on Plasmodium berghei K173 strain.
Topics: Agmatine; Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Resistance; Eflornithine | 2003 |
Examples of tropical disease control in the humanitarian medical programmes of MSF and Merlin.
Topics: Antimalarials; Artemether; Artemisinins; Attitude to Health; Child; Child, Preschool; Communicable D | 2006 |
Polyamine levels and the activity of their biosynthetic enzymes in human erythrocytes infected with the malarial parasite, Plasmodium falciparum.
Topics: Adenosylmethionine Decarboxylase; Blood Proteins; Carboxy-Lyases; Cells, Cultured; Eflornithine; Ery | 1984 |
Inhibitory action of alpha-difluoromethylornithine on rodent malaria (Plasmodium berghei).
Topics: Animals; Blood; Eflornithine; Erythrocytes; Malaria; Mice; Ornithine; Plasmodium berghei | 1982 |
Evaluation of alpha-difluoromethylornithine (DFMO) as a tool to induce protective immunity against Plasmodium berghei malaria.
Topics: Animals; Eflornithine; Female; Malaria; Mice; Mice, Inbred BALB C; Parasitemia; Plasmodium berghei; | 1997 |
Bis(benzyl)polyamine analogs inhibit the growth of chloroquine-resistant human malaria parasites (Plasmodium falciparum) in vitro and in combination with alpha-difluoromethylornithine cure murine malaria.
Topics: Animals; Antimalarials; Chloroquine; DNA; Drug Resistance; Drug Therapy, Combination; Eflornithine; | 1989 |
Ornithine decarboxylase inhibition and the malaria-infected red cell: a model for polyamine metabolism and growth.
Topics: Cells, Cultured; DNA; Eflornithine; Erythrocytes; Humans; Malaria; Ornithine; Ornithine Decarboxylas | 1985 |
Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Eflornithine; Erythrocytes; Humans; Liver Neoplasms; | 1985 |
alpha-Difluoromethylornithine induces protective immunity in mice inoculated with Plasmodium berghei sporozoites.
Topics: Animals; Chloroquine; Eflornithine; Immunization; Malaria; Mice; Plasmodium berghei | 1986 |
Plasmodium falciparum and Plasmodium berghei: effects of ornithine decarboxylase inhibitors on erythrocytic schizogony.
Topics: Animals; Eflornithine; Malaria; Ornithine Decarboxylase Inhibitors; Plasmodium berghei; Plasmodium f | 1987 |