eflornithine has been researched along with Lupus Erythematosus, Systemic in 4 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thomas, TJ | 4 |
| Messner, RP | 1 |
| Gunnia, UB | 3 |
| Seibold, JR | 2 |
| Thomas, T | 3 |
4 other studies available for eflornithine and Lupus Erythematosus, Systemic
| Article | Year |
|---|---|
Beneficial effects of a polyamine biosynthesis inhibitor on lupus in MRL-lpr/lpr mice.
Topics: Animals; Antibodies, Antinuclear; Biogenic Polyamines; DNA; Eflornithine; Enzyme Inhibitors; Female; | 1989 |
Defective signal-transduction pathways in T-cells from autoimmune MRL-lpr/lpr mice are associated with increased polyamine concentrations.
Topics: Animals; Autoimmune Diseases; Blotting, Western; Calcium; CD4-CD8 Ratio; Concanavalin A; Eflornithin | 1995 |
Reversal of the abnormal development of T cell subpopulations in the thymus of autoimmune MRL-lpr/lpr mice by a polyamine biosynthesis inhibitor.
Topics: Animals; Autoimmunity; CD4-CD8 Ratio; Disease Models, Animal; Eflornithine; Lupus Erythematosus, Sys | 1992 |
Restoration of the DNA binding activity of estrogen receptor in MRL-lpr/lpr mice by a polyamine biosynthesis inhibitor.
Topics: Animals; DNA; Down-Regulation; Eflornithine; Female; Lupus Erythematosus, Systemic; Mice; Mice, Inbr | 1991 |