eflornithine has been researched along with Liver Neoplasms in 5 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The antimalarial drug, primaquine, the side chain of which is structurally analogous to a natural polyamine, did not enhance the activity of alpha-difluoromethylornithine or alpha-monofluoromethyldehydroornithine methyl ester." | 3.67 | Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony. ( Hollingdale, MR; McCann, PP; Sjoerdsma, A, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Santos, AA | 1 |
| Stubbs, AP | 1 |
| Maghsoudloo, M | 1 |
| Murphy, GM | 1 |
| Wilkinson, ML | 1 |
| Takahashi, Y | 1 |
| Mai, M | 1 |
| Nishioka, K | 1 |
| Nakagawa, T | 1 |
| Nakao, Y | 1 |
| Matsui, T | 1 |
| Koizumi, T | 1 |
| Watanabe, S | 1 |
| Fujita, T | 1 |
| Lipton, A | 1 |
| Harvey, HA | 1 |
| Glenn, J | 1 |
| Weidner, WA | 1 |
| Strauss, M | 1 |
| Miller, SE | 1 |
| Taylor, JB | 1 |
| White-Hershey, D | 1 |
| Barlow, JL | 1 |
| Hollingdale, MR | 1 |
| McCann, PP | 1 |
| Sjoerdsma, A | 1 |
5 other studies available for eflornithine and Liver Neoplasms
| Article | Year |
|---|---|
Polyamine metabolism in human hepatocellular cancer cells (Hep-G2).
Topics: Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line; DNA, Neoplasm; Eflornithine; Humans; Liv | 1994 |
alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Division; Disease Models, Animal; Eflornithine; Endo | 2000 |
Effects of alpha-difluoromethyl ornithine on alpha-fetoprotein and albumin secretion in human hepatoma cell line, PLC/PRF/5.
Topics: Albumins; alpha-Fetoproteins; Carcinoma, Hepatocellular; Cell Line; Cycloheximide; Dose-Response Rel | 1985 |
A phase I study of hepatic arterial infusion using difluoromethylornithine.
Topics: Adult; Aged; Drug Evaluation; Eflornithine; Hearing Loss, Bilateral; Hepatic Artery; Humans; Infusio | 1989 |
Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Eflornithine; Erythrocytes; Humans; Liver Neoplasms; | 1985 |