Page last updated: 2024-10-25

eflornithine and Leukemia

eflornithine has been researched along with Leukemia in 10 studies

Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
" Vomiting, necessitating dosage reduction, was a significant problem at the highest dose administered."1.27Phase I evaluation of intravenous difluoromethylornithine--a polyamine inhibitor. ( Estey, E; Freireich, EJ; Keating, MJ; Maddox, AM; McCredie, KE, 1985)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19909 (90.00)18.7374
1990's0 (0.00)18.2507
2000's1 (10.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Clark, SS1
Warrell, RP1
Burchenal, JH1
Jänne, J1
Alhonen-Hongisto, L1
Seppänen, P1
Siimes, M1
Maddox, AM6
Keating, MJ5
Freireich, EJ5
Haddox, MK5
Williams-Ashman, HG1
Seidenfeld, J1
Orengo, I1
Frasier-Scott, KF1
McCredie, KE1
Estey, E1

Reviews

3 reviews available for eflornithine and Leukemia

ArticleYear
Methylglyoxal-bis(guanylhydrazone) (Methyl-GAG): current status and future prospects.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1983, Volume: 1, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemical Phenomena; Chemistry; Clinical Tri

1983
Use of polyamine antimetabolites in experimental tumours and in human leukemia.
    Medical biology, 1981, Volume: 59, Issue:5-6

    Topics: Animals; Antimetabolites, Antineoplastic; Drug Administration Schedule; Drug Therapy, Combination; E

1981
Aspects of the biochemical pharmacology of methyl glyoxal bis(guanylhydrazone).
    Biochemical pharmacology, 1986, Apr-15, Volume: 35, Issue:8

    Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Amine Oxidase (Copper-Containing); Carnitine;

1986

Trials

1 trial available for eflornithine and Leukemia

ArticleYear
Methylglyoxal-bis(guanylhydrazone) (Methyl-GAG): current status and future prospects.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1983, Volume: 1, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemical Phenomena; Chemistry; Clinical Tri

1983

Other Studies

7 other studies available for eflornithine and Leukemia

ArticleYear
Perillyl alcohol induces c-Myc-dependent apoptosis in Bcr/Abl-transformed leukemia cells.
    Oncology, 2006, Volume: 70, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Eflornithine; Enzyme Induction; Enzyme

2006
Mononuclear cell polyamine content associated with myeloid maturation in patients with leukemia during administration of polyamine inhibitors.
    Investigational new drugs, 1989, Volume: 7, Issue:2-3

    Topics: Adolescent; Adult; Aged; Biogenic Polyamines; Bone Marrow; Bone Marrow Cells; Drug Evaluation; Eflor

1989
Difluoromethylornithine enhances the uptake of methylglyoxal-bis(guanylhydrazone) prior to inhibiting leukemic cell proliferation.
    Chemotherapy, 1987, Volume: 33, Issue:2

    Topics: Cell Division; Cells, Cultured; Eflornithine; Female; Humans; Leukemia; Mitoguazone; Ornithine Decar

1987
Alterations in bone marrow and blood mononuclear cell polyamine and methylglyoxal bis(guanylhydrazone) levels: phase I evaluation of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) treatment of human hematological malignancies.
    Cancer research, 1988, Mar-01, Volume: 48, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Drug Evaluation; Eflornith

1988
Alterations in human circulating and bone marrow mononuclear cell polyamine levels in hematologic malignancies as a consequence of difluoromethylornithine administration.
    Investigational new drugs, 1988, Volume: 6, Issue:2

    Topics: Adolescent; Adult; Aged; Biogenic Polyamines; Bone Marrow; Eflornithine; Female; Humans; Leukemia; L

1988
Polyamines increase in human peripheral blood and bone marrow mononuclear cells following administration of methylglyoxal bis(guanylhydrazone).
    Chemotherapy, 1988, Volume: 34, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biogenic Polyamines; Bone Marrow; Drug

1988
Phase I evaluation of intravenous difluoromethylornithine--a polyamine inhibitor.
    Investigational new drugs, 1985, Volume: 3, Issue:3

    Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Agents; Drug Evaluation; Eflornithine; Humans

1985