eflornithine has been researched along with Leukemia in 10 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Vomiting, necessitating dosage reduction, was a significant problem at the highest dose administered." | 1.27 | Phase I evaluation of intravenous difluoromethylornithine--a polyamine inhibitor. ( Estey, E; Freireich, EJ; Keating, MJ; Maddox, AM; McCredie, KE, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (90.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Clark, SS | 1 |
| Warrell, RP | 1 |
| Burchenal, JH | 1 |
| Jänne, J | 1 |
| Alhonen-Hongisto, L | 1 |
| Seppänen, P | 1 |
| Siimes, M | 1 |
| Maddox, AM | 6 |
| Keating, MJ | 5 |
| Freireich, EJ | 5 |
| Haddox, MK | 5 |
| Williams-Ashman, HG | 1 |
| Seidenfeld, J | 1 |
| Orengo, I | 1 |
| Frasier-Scott, KF | 1 |
| McCredie, KE | 1 |
| Estey, E | 1 |
3 reviews available for eflornithine and Leukemia
| Article | Year |
|---|---|
Methylglyoxal-bis(guanylhydrazone) (Methyl-GAG): current status and future prospects.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemical Phenomena; Chemistry; Clinical Tri | 1983 |
Use of polyamine antimetabolites in experimental tumours and in human leukemia.
Topics: Animals; Antimetabolites, Antineoplastic; Drug Administration Schedule; Drug Therapy, Combination; E | 1981 |
Aspects of the biochemical pharmacology of methyl glyoxal bis(guanylhydrazone).
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Amine Oxidase (Copper-Containing); Carnitine; | 1986 |
1 trial available for eflornithine and Leukemia
| Article | Year |
|---|---|
Methylglyoxal-bis(guanylhydrazone) (Methyl-GAG): current status and future prospects.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemical Phenomena; Chemistry; Clinical Tri | 1983 |
7 other studies available for eflornithine and Leukemia
| Article | Year |
|---|---|
Perillyl alcohol induces c-Myc-dependent apoptosis in Bcr/Abl-transformed leukemia cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Eflornithine; Enzyme Induction; Enzyme | 2006 |
Mononuclear cell polyamine content associated with myeloid maturation in patients with leukemia during administration of polyamine inhibitors.
Topics: Adolescent; Adult; Aged; Biogenic Polyamines; Bone Marrow; Bone Marrow Cells; Drug Evaluation; Eflor | 1989 |
Difluoromethylornithine enhances the uptake of methylglyoxal-bis(guanylhydrazone) prior to inhibiting leukemic cell proliferation.
Topics: Cell Division; Cells, Cultured; Eflornithine; Female; Humans; Leukemia; Mitoguazone; Ornithine Decar | 1987 |
Alterations in bone marrow and blood mononuclear cell polyamine and methylglyoxal bis(guanylhydrazone) levels: phase I evaluation of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) treatment of human hematological malignancies.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Drug Evaluation; Eflornith | 1988 |
Alterations in human circulating and bone marrow mononuclear cell polyamine levels in hematologic malignancies as a consequence of difluoromethylornithine administration.
Topics: Adolescent; Adult; Aged; Biogenic Polyamines; Bone Marrow; Eflornithine; Female; Humans; Leukemia; L | 1988 |
Polyamines increase in human peripheral blood and bone marrow mononuclear cells following administration of methylglyoxal bis(guanylhydrazone).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biogenic Polyamines; Bone Marrow; Drug | 1988 |
Phase I evaluation of intravenous difluoromethylornithine--a polyamine inhibitor.
Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Agents; Drug Evaluation; Eflornithine; Humans | 1985 |