eflornithine has been researched along with Leukemia, Myeloid in 4 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Leukemia, Myeloid: Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The human promyelocytic leukemia cell line, HL-60, differentiated into macrophage/monocytes in the presence of 1 alpha,25-dihydroxycholecalciferol [1 alpha,25(OH)2D3], as assessed by the percentage of morphologically mature cells and their ability to reduce nitroblue tetrazolium." | 1.27 | Polyamines in 1 alpha, 25-dihydroxycholecalciferol-induced differentiation of human promyelocytic leukemia cells, HL-60. ( Inaba, M; Ishimura, E; Matsui-Yuasa, I; Morii, H; Morisada, S; Morisawa, S; Nishizawa, Y; Otani, S; Yukioka, K; Yukioka, M, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tjandrawinata, RR | 1 |
| Hawel, L | 1 |
| Byus, CV | 1 |
| Aller, P | 1 |
| Rius, C | 1 |
| Mata, F | 1 |
| Zorrilla, A | 1 |
| Cabañas, C | 1 |
| Bellón, T | 1 |
| Bernabeu, C | 1 |
| Inaba, M | 1 |
| Otani, S | 1 |
| Matsui-Yuasa, I | 1 |
| Yukioka, K | 1 |
| Nishizawa, Y | 1 |
| Ishimura, E | 1 |
| Morisada, S | 1 |
| Yukioka, M | 1 |
| Morisawa, S | 1 |
| Morii, H | 1 |
| Gastaut, JA | 1 |
| Tell, G | 1 |
| Schechter, PJ | 1 |
| Maraninchi, D | 1 |
| Mascret, B | 1 |
| Carcassonne, Y | 1 |
4 other studies available for eflornithine and Leukemia, Myeloid
| Article | Year |
|---|---|
Regulation of putrescine export in lipopolysaccharide or IFN-gamma-activated murine monocytic-leukemic RAW 264 cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; DNA; Dose-Response Relationship, Drug; Eflornithine | 1994 |
Camptothecin induces differentiation and stimulates the expression of differentiation-related genes in U-937 human promonocytic leukemia cells.
Topics: Camptothecin; Cell Differentiation; DNA, Neoplasm; Eflornithine; Gene Expression Regulation, Leukemi | 1992 |
Polyamines in 1 alpha, 25-dihydroxycholecalciferol-induced differentiation of human promyelocytic leukemia cells, HL-60.
Topics: Acetyltransferases; Calcitriol; Cell Differentiation; Cell Division; Cell Line; Eflornithine; Humans | 1986 |
Treatment of acute myeloid leukemia and blastic phase of chronic myeloid leukemia with combined eflornithine (alpha difluoromethylornithine) and methylglyoxal-bis-guanyl hydrazone (methyl-GAG).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Eflornithine; Female; | 1987 |