eflornithine has been researched along with Leukemia, Myeloid, Acute in 5 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sugiura, M | 1 |
| Shafman, T | 2 |
| Mitchell, T | 2 |
| Griffin, J | 2 |
| Kufe, D | 1 |
| Kufe, DW | 1 |
| Siimes, M | 1 |
| Seppänen, P | 1 |
| Alhonen-Hongisto, L | 1 |
| Jänne, J | 1 |
| Bakic, M | 1 |
| Chan, D | 1 |
| Freireich, EJ | 1 |
| Marton, LJ | 1 |
| Zwelling, LA | 1 |
| Gastaut, JA | 1 |
| Tell, G | 1 |
| Schechter, PJ | 1 |
| Maraninchi, D | 1 |
| Mascret, B | 1 |
| Carcassonne, Y | 1 |
5 other studies available for eflornithine and Leukemia, Myeloid, Acute
| Article | Year |
|---|---|
Involvement of spermidine in proliferation and differentiation of human promyelocytic leukemia cells.
Topics: Acetamides; Antineoplastic Agents; Cell Line; Cell Transformation, Neoplastic; DNA; Eflornithine; Hu | 1984 |
Polyamine requirements for induction of HL-60 promyelocyte differentiation by leukocyte-conditioned medium and phorbol ester.
Topics: Antibodies, Monoclonal; Cell Differentiation; Cell Line; Culture Media; Eflornithine; Humans; Kineti | 1984 |
Synergistic action of two polyamine antimetabolites leads to a rapid therapeutic response in childhood leukemia.
Topics: Antineoplastic Agents; Child; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combinatio | 1981 |
Effect of polyamine depletion by alpha-difluoromethylornithine or (2R,5R)-6-heptyne-2,5-diamine on drug-induced topoisomerase II-mediated DNA cleavage and cytotoxicity in human and murine leukemia cells.
Topics: Alkynes; Amsacrine; Animals; Antineoplastic Agents; Cell Line; Cell Survival; Diamines; DNA; DNA Dam | 1987 |
Treatment of acute myeloid leukemia and blastic phase of chronic myeloid leukemia with combined eflornithine (alpha difluoromethylornithine) and methylglyoxal-bis-guanyl hydrazone (methyl-GAG).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Eflornithine; Female; | 1987 |