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eflornithine and Leukemia, Myeloid, Acute

eflornithine has been researched along with Leukemia, Myeloid, Acute in 5 studies

Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.

Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19905 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sugiura, M1
Shafman, T2
Mitchell, T2
Griffin, J2
Kufe, D1
Kufe, DW1
Siimes, M1
Seppänen, P1
Alhonen-Hongisto, L1
Jänne, J1
Bakic, M1
Chan, D1
Freireich, EJ1
Marton, LJ1
Zwelling, LA1
Gastaut, JA1
Tell, G1
Schechter, PJ1
Maraninchi, D1
Mascret, B1
Carcassonne, Y1

Other Studies

5 other studies available for eflornithine and Leukemia, Myeloid, Acute

ArticleYear
Involvement of spermidine in proliferation and differentiation of human promyelocytic leukemia cells.
    Blood, 1984, Volume: 63, Issue:5

    Topics: Acetamides; Antineoplastic Agents; Cell Line; Cell Transformation, Neoplastic; DNA; Eflornithine; Hu

1984
Polyamine requirements for induction of HL-60 promyelocyte differentiation by leukocyte-conditioned medium and phorbol ester.
    Cancer research, 1984, Volume: 44, Issue:10

    Topics: Antibodies, Monoclonal; Cell Differentiation; Cell Line; Culture Media; Eflornithine; Humans; Kineti

1984
Synergistic action of two polyamine antimetabolites leads to a rapid therapeutic response in childhood leukemia.
    International journal of cancer, 1981, Nov-15, Volume: 28, Issue:5

    Topics: Antineoplastic Agents; Child; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combinatio

1981
Effect of polyamine depletion by alpha-difluoromethylornithine or (2R,5R)-6-heptyne-2,5-diamine on drug-induced topoisomerase II-mediated DNA cleavage and cytotoxicity in human and murine leukemia cells.
    Cancer research, 1987, Dec-15, Volume: 47, Issue:24 Pt 1

    Topics: Alkynes; Amsacrine; Animals; Antineoplastic Agents; Cell Line; Cell Survival; Diamines; DNA; DNA Dam

1987
Treatment of acute myeloid leukemia and blastic phase of chronic myeloid leukemia with combined eflornithine (alpha difluoromethylornithine) and methylglyoxal-bis-guanyl hydrazone (methyl-GAG).
    Cancer chemotherapy and pharmacology, 1987, Volume: 20, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Eflornithine; Female;

1987