eflornithine has been researched along with Leukemia, Myelogenous, Chronic, BCR-ABL Positive in 3 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grzelkowska, K | 2 |
| Motyl, T | 2 |
| Ostrowski, J | 1 |
| Trzeciak, L | 1 |
| Ask, A | 1 |
| Persson, L | 1 |
| Rehnholm, A | 1 |
| Frostesjö, L | 1 |
| Holm, I | 1 |
| Heby, O | 1 |
| Kasterka, M | 1 |
| Blachowski, S | 1 |
| Sysa, P | 1 |
3 other studies available for eflornithine and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
| Article | Year |
|---|---|
The effect of OA on proliferation and polyamine metabolism of K 562 leukemic cells and their responsiveness to natural killer cell activity.
Topics: Base Sequence; Biogenic Polyamines; Cell Division; Eflornithine; Humans; Killer Cells, Natural; Leuk | 1995 |
Development of resistance to hydroxyurea during treatment of human myelogenous leukemia K562 cells with alpha-difluoromethylornithine as a result of coamplification of genes for ornithine decarboxylase and ribonucleotide reductase R2 subunit.
Topics: Animals; Blotting, Northern; Blotting, Southern; Cricetinae; Cricetulus; DNA Probes; Drug Resistance | 1993 |
TGF-beta 1 inhibits polyamine biosynthesis in K 562 leukemic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosylmethionine Decarboxylase; Apoptosis; Cell Div | 1993 |