eflornithine has been researched along with Leukemia, Lymphocytic in 4 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The two lines are murine lymphocytic leukemia cells which differ in their ability to metabolize 5'-methylthioadenosine, the by-product of polyamine biosynthesis: L5178Y cells contain a specific 5'-methylthioadenosine phosphorylase; L1210 cells do not." | 1.27 | Comparison of the biological effects of four irreversible inhibitors of ornithine decarboxylase in two murine lymphocytic leukemia cell lines. ( Kramer, DL; Pera, PJ; Porter, CW; Sufrin, JR, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Seppänen, P | 2 |
| Alhonen-Hongisto, L | 2 |
| Jänne, J | 2 |
| Siimes, M | 1 |
| Rosenblum, MG | 1 |
| Pera, PJ | 1 |
| Kramer, DL | 1 |
| Sufrin, JR | 1 |
| Porter, CW | 1 |
4 other studies available for eflornithine and Leukemia, Lymphocytic
| Article | Year |
|---|---|
Polyamine deprivation-induced enhanced uptake of methylglyoxal bis(guanylhydrazone) by tumor cells.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Line; Eflornithine; Female; Guanidine | 1981 |
Synergistic action of two polyamine antimetabolites leads to a rapid therapeutic response in childhood leukemia.
Topics: Antineoplastic Agents; Child; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combinatio | 1981 |
Biochemical effects of human alpha interferon in combination with alpha-difluoromethylornithine on human lymphoblastoid (DAUDI) cells in culture.
Topics: 2',5'-Oligoadenylate Synthetase; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Eflo | 1991 |
Comparison of the biological effects of four irreversible inhibitors of ornithine decarboxylase in two murine lymphocytic leukemia cell lines.
Topics: Alkynes; Animals; Biological Transport; Cell Cycle; Cell Survival; Diamines; Eflornithine; Leukemia | 1986 |