eflornithine has been researched along with Leucocythaemia in 10 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Vomiting, necessitating dosage reduction, was a significant problem at the highest dose administered." | 1.27 | Phase I evaluation of intravenous difluoromethylornithine--a polyamine inhibitor. ( Estey, E; Freireich, EJ; Keating, MJ; Maddox, AM; McCredie, KE, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (90.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Clark, SS | 1 |
| Warrell, RP | 1 |
| Burchenal, JH | 1 |
| Jänne, J | 1 |
| Alhonen-Hongisto, L | 1 |
| Seppänen, P | 1 |
| Siimes, M | 1 |
| Maddox, AM | 6 |
| Keating, MJ | 5 |
| Freireich, EJ | 5 |
| Haddox, MK | 5 |
| Williams-Ashman, HG | 1 |
| Seidenfeld, J | 1 |
| Orengo, I | 1 |
| Frasier-Scott, KF | 1 |
| McCredie, KE | 1 |
| Estey, E | 1 |
3 reviews available for eflornithine and Leucocythaemia
| Article | Year |
|---|---|
Methylglyoxal-bis(guanylhydrazone) (Methyl-GAG): current status and future prospects.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemical Phenomena; Chemistry; Clinical Tri | 1983 |
Use of polyamine antimetabolites in experimental tumours and in human leukemia.
Topics: Animals; Antimetabolites, Antineoplastic; Drug Administration Schedule; Drug Therapy, Combination; E | 1981 |
Aspects of the biochemical pharmacology of methyl glyoxal bis(guanylhydrazone).
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Amine Oxidase (Copper-Containing); Carnitine; | 1986 |
1 trial available for eflornithine and Leucocythaemia
| Article | Year |
|---|---|
Methylglyoxal-bis(guanylhydrazone) (Methyl-GAG): current status and future prospects.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemical Phenomena; Chemistry; Clinical Tri | 1983 |
7 other studies available for eflornithine and Leucocythaemia
| Article | Year |
|---|---|
Perillyl alcohol induces c-Myc-dependent apoptosis in Bcr/Abl-transformed leukemia cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Eflornithine; Enzyme Induction; Enzyme | 2006 |
Mononuclear cell polyamine content associated with myeloid maturation in patients with leukemia during administration of polyamine inhibitors.
Topics: Adolescent; Adult; Aged; Biogenic Polyamines; Bone Marrow; Bone Marrow Cells; Drug Evaluation; Eflor | 1989 |
Difluoromethylornithine enhances the uptake of methylglyoxal-bis(guanylhydrazone) prior to inhibiting leukemic cell proliferation.
Topics: Cell Division; Cells, Cultured; Eflornithine; Female; Humans; Leukemia; Mitoguazone; Ornithine Decar | 1987 |
Alterations in bone marrow and blood mononuclear cell polyamine and methylglyoxal bis(guanylhydrazone) levels: phase I evaluation of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) treatment of human hematological malignancies.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Drug Evaluation; Eflornith | 1988 |
Alterations in human circulating and bone marrow mononuclear cell polyamine levels in hematologic malignancies as a consequence of difluoromethylornithine administration.
Topics: Adolescent; Adult; Aged; Biogenic Polyamines; Bone Marrow; Eflornithine; Female; Humans; Leukemia; L | 1988 |
Polyamines increase in human peripheral blood and bone marrow mononuclear cells following administration of methylglyoxal bis(guanylhydrazone).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biogenic Polyamines; Bone Marrow; Drug | 1988 |
Phase I evaluation of intravenous difluoromethylornithine--a polyamine inhibitor.
Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Agents; Drug Evaluation; Eflornithine; Humans | 1985 |