eflornithine has been researched along with Leishmaniasis, Visceral in 4 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Leishmaniasis, Visceral: A chronic disease caused by LEISHMANIA DONOVANI and transmitted by the bite of several sandflies of the genera Phlebotomus and Lutzomyia. It is commonly characterized by fever, chills, vomiting, anemia, hepatosplenomegaly, leukopenia, hypergammaglobulinemia, emaciation, and an earth-gray color of the skin. The disease is classified into three main types according to geographic distribution: Indian, Mediterranean (or infantile), and African.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Singh, S | 1 |
| Mukherjee, A | 1 |
| Khomutov, AR | 1 |
| Persson, L | 1 |
| Heby, O | 1 |
| Chatterjee, M | 1 |
| Madhubala, R | 2 |
| Olenyik, T | 1 |
| Gilroy, C | 1 |
| Ullman, B | 1 |
| Mukhopadhyay, R | 1 |
| Gradoni, L | 1 |
| Iorio, MA | 1 |
| Gramiccia, M | 1 |
| Orsini, S | 1 |
4 other studies available for eflornithine and Leishmaniasis, Visceral
| Article | Year |
|---|---|
Antileishmanial effect of 3-aminooxy-1-aminopropane is due to polyamine depletion.
Topics: Animals; Drug Resistance; Leishmania donovani; Leishmaniasis, Visceral; Ornithine Decarboxylase; Orn | 2007 |
Oral putrescine restores virulence of ornithine decarboxylase-deficient Leishmania donovani in mice.
Topics: Administration, Oral; Animals; Disease Models, Animal; Eflornithine; Enzyme Inhibitors; Female; Leis | 2011 |
Effect of a bis(benzyl)polyamine analogue, and DL-alpha-difluoromethylornithine on parasite suppression and cellular polyamine levels in golden hamster during Leishmania donovani infection.
Topics: Animals; Antimony Sodium Gluconate; Biogenic Polyamines; Cricetinae; Eflornithine; Leishmania donova | 1993 |
In vivo effect of eflornithine (DFMO) and some related compounds on Leishmania infantum preliminary communication.
Topics: Animals; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Eflornithine; Leishmania d | 1989 |