eflornithine has been researched along with Kidney Neoplasms in 14 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Kidney Neoplasms: Tumors or cancers of the KIDNEY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of human recombinant interferon-alpha 2 (IFN-alpha 2) and alpha-difluoromethylornithine (DFMO) as single agents and in combination were studied for efficacy against the renal cell adenocarcinoma (JDF-1) in an in vitro clonogenic assay and in vivo as xenografts in nude mice." | 7.67 | Effects of alpha-difluoromethylornithine and recombinant interferon-alpha 2 on the growth of a human renal cell adenocarcinoma xenograft in nude mice. ( Fleischmann, J; Heston, WD; Ratliff, TL; Tackett, RE, 1984) |
| "alpha-Difluoromethylornithine (DFMO) and methylglyoxal bis-(guanylhydrazone) (MGBG) were tested against a murine renal adenocarcinoma, because polyamines are necessary for neoplastic cell growth and because human renal adenocarcinomas contain higher levels of spermidine than do normal renal cells; MGBG inhibits spermidine synthesis and has some activity against human renal tumors; DFMO irreversibly inhibits ornithine decarboxylase, the first rate-limiting enzyme controlling polyamine biosynthesis; and DFMO promotes intracellular accumulation of MGBG in experimental tumor models and human leukemia." | 7.67 | Effects of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the growth of experimental renal adenocarcinoma in mice. ( Burchenal, JH; Conti, PS; Herr, HW; Kleinert, EL; Whitmore, WF, 1984) |
| "The effects of human recombinant interferon-alpha 2 (IFN-alpha 2) and alpha-difluoromethylornithine (DFMO) as single agents and in combination were studied for efficacy against the renal cell adenocarcinoma (JDF-1) in an in vitro clonogenic assay and in vivo as xenografts in nude mice." | 3.67 | Effects of alpha-difluoromethylornithine and recombinant interferon-alpha 2 on the growth of a human renal cell adenocarcinoma xenograft in nude mice. ( Fleischmann, J; Heston, WD; Ratliff, TL; Tackett, RE, 1984) |
| "alpha-Difluoromethylornithine (DFMO) and methylglyoxal bis-(guanylhydrazone) (MGBG) were tested against a murine renal adenocarcinoma, because polyamines are necessary for neoplastic cell growth and because human renal adenocarcinomas contain higher levels of spermidine than do normal renal cells; MGBG inhibits spermidine synthesis and has some activity against human renal tumors; DFMO irreversibly inhibits ornithine decarboxylase, the first rate-limiting enzyme controlling polyamine biosynthesis; and DFMO promotes intracellular accumulation of MGBG in experimental tumor models and human leukemia." | 3.67 | Effects of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the growth of experimental renal adenocarcinoma in mice. ( Burchenal, JH; Conti, PS; Herr, HW; Kleinert, EL; Whitmore, WF, 1984) |
| "Difluoromethylornithine (DFMO) and methylglyoxal bis (guanylhydrazone) (MGBG), inhibitors of ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AMDC), respectively, were tested for antitumor activity in the BALB/C mouse renal adenocarcinoma model, wherein ODC and AMDC activity are elevated compared to the normal kidney." | 3.66 | Experimental chemotherapy in a transplantable renal adenocarcinoma. I: Effects of some inhibitors of polyamine synthesis. ( Dunzendorfer, U; Kleinert, E; Whitmore, WF, 1983) |
| "The antiproliferative effects of human recombinant interferon gamma (IFN gamma) in combination with alpha-difluoromethylornithine (DFMO) or as single agents were assessed on human cell cultures derived from carcinomas of the breast (MCF-7), the ovary (EFO-27) or the kidneys (EGI-4)." | 1.29 | Antiproliferative effects of interferon gamma in combination with alpha-difluoromethylornithine on human carcinoma cell cultures. ( Hölzel, F; Kirchner, H; Klouche, M, 1994) |
| "Ethylnitrosourea was given to pregnant rats as a single i." | 1.28 | Study of postnatal effects of chemopreventive agents on offspring of ethylnitrosourea-induced transplacental carcinogenesis in rats. I. Influence of retinol acetate, alpha-tocopherol acetate, thiamine chloride, sodium selenite, and alpha-difluoromethylorn ( Alexandrov, VA; Bespalov, VG; Boone, CW; Kelloff, GJ; Malone, WF, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (85.71) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dunzendorfer, U | 3 |
| Warrell, RP | 1 |
| Burchenal, JH | 2 |
| Kingsnorth, AN | 2 |
| McCann, PP | 1 |
| Diekema, KA | 1 |
| Ross, JS | 2 |
| Malt, RA | 2 |
| Kleinert, E | 1 |
| Whitmore, WF | 2 |
| Heston, WD | 2 |
| Fleischmann, J | 2 |
| Tackett, RE | 1 |
| Ratliff, TL | 2 |
| Herr, HW | 1 |
| Kleinert, EL | 1 |
| Conti, PS | 1 |
| Klouche, M | 1 |
| Kirchner, H | 1 |
| Hölzel, F | 1 |
| Alexandrov, VA | 1 |
| Bespalov, VG | 1 |
| Boone, CW | 1 |
| Kelloff, GJ | 1 |
| Malone, WF | 1 |
| Pine, MJ | 1 |
| Huben, RP | 1 |
| Pegg, AE | 1 |
| Gohji, K | 2 |
| Murao, S | 1 |
| Maeda, S | 1 |
| Sugiyama, T | 1 |
| Kamidono, S | 2 |
| Bander, NH | 1 |
| Bauer, WC | 1 |
| Janney, C | 1 |
| Fair, WR | 1 |
| Lamuraglia, GM | 1 |
| Lacaine, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Urinary Excretion of Acetylamantadine by Cancer Patients[NCT02277938] | 120 participants (Anticipated) | Observational | 2013-08-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for eflornithine and Kidney Neoplasms
| Article | Year |
|---|---|
Methylglyoxal-bis(guanylhydrazone) (Methyl-GAG): current status and future prospects.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemical Phenomena; Chemistry; Clinical Tri | 1983 |
Chemoprevention and chemotherapy by inhibition of ornithine decarboxylase activity and polyamine synthesis: colonic, pancreatic, mammary, and renal carcinomas.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Division; Colonic Neoplasms; Eflornithine; Fe | 1985 |
1 trial available for eflornithine and Kidney Neoplasms
| Article | Year |
|---|---|
Methylglyoxal-bis(guanylhydrazone) (Methyl-GAG): current status and future prospects.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemical Phenomena; Chemistry; Clinical Tri | 1983 |
12 other studies available for eflornithine and Kidney Neoplasms
| Article | Year |
|---|---|
The effect of alpha-difluoromethyl-ornithine on tumor growth, acute phase reactants, beta-2-microglobulin and hydroxyproline in kidney and bladder carcinomas.
Topics: 17-Ketosteroids; Adenocarcinoma; Adult; Aged; alpha 1-Antitrypsin; Antineoplastic Agents; beta 2-Mic | 1981 |
Effects of alpha-difluoromethylornithine on the growth of experimental Wilms' tumor and renal adenocarcinoma.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Drug Evaluation, Preclinical; Eflornithine; Kidney N | 1983 |
Experimental chemotherapy in a transplantable renal adenocarcinoma. I: Effects of some inhibitors of polyamine synthesis.
Topics: Adenocarcinoma; Animals; Eflornithine; Guanidines; Kidney; Kidney Neoplasms; Mice; Mice, Inbred BALB | 1983 |
Effects of alpha-difluoromethylornithine and recombinant interferon-alpha 2 on the growth of a human renal cell adenocarcinoma xenograft in nude mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Cell Line; Clone Cells; Drug Synergis | 1984 |
Effects of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the growth of experimental renal adenocarcinoma in mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Body Weight; Cell Division; Drug Synergism; Eflornit | 1984 |
Antiproliferative effects of interferon gamma in combination with alpha-difluoromethylornithine on human carcinoma cell cultures.
Topics: Breast Neoplasms; Cell Division; Drug Synergism; Eflornithine; Female; Growth Inhibitors; Humans; In | 1994 |
Study of postnatal effects of chemopreventive agents on offspring of ethylnitrosourea-induced transplacental carcinogenesis in rats. I. Influence of retinol acetate, alpha-tocopherol acetate, thiamine chloride, sodium selenite, and alpha-difluoromethylorn
Topics: alpha-Tocopherol; Animals; Antioxidants; Diterpenes; Eflornithine; Ethylnitrosourea; Female; Kidney | 1991 |
Production of N1-acetyl spermidine by renal cell tumors.
Topics: Animals; Carcinoma, Renal Cell; Carmustine; Eflornithine; Female; Kidney Neoplasms; Mice; Mice, Inbr | 1989 |
Enhanced inhibition of colony formation of human renal cell carcinoma in soft agar by the combination of alpha-difluoromethylornithine and recombinant gamma-interferon.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cells, Cultured; Eflornithine | 1986 |
[Study on anticancer chemotherapy of human renal cell carcinoma. The combined effect of interferon and other anticancer drugs].
Topics: Antineoplastic Agents; Carcinoma, Renal Cell; Combined Modality Therapy; Eflornithine; Humans; Inter | 1987 |
Human renal cell carcinoma xenograft: morphology, growth and chemosensitivities.
Topics: Aged; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Antineoplastic Agents; Antineoplastic Com | 1985 |
[Polyamines, polyamine antimetabolites and urogenital tumors. State of research and clinical results].
Topics: Adenosylmethionine Decarboxylase; Antimetabolites, Antineoplastic; Carboxy-Lyases; Drug Combinations | 1985 |