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eflornithine and Kidney Neoplasms

eflornithine has been researched along with Kidney Neoplasms in 14 studies

Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.

Kidney Neoplasms: Tumors or cancers of the KIDNEY.

Research Excerpts

ExcerptRelevanceReference
"The effects of human recombinant interferon-alpha 2 (IFN-alpha 2) and alpha-difluoromethylornithine (DFMO) as single agents and in combination were studied for efficacy against the renal cell adenocarcinoma (JDF-1) in an in vitro clonogenic assay and in vivo as xenografts in nude mice."7.67Effects of alpha-difluoromethylornithine and recombinant interferon-alpha 2 on the growth of a human renal cell adenocarcinoma xenograft in nude mice. ( Fleischmann, J; Heston, WD; Ratliff, TL; Tackett, RE, 1984)
"alpha-Difluoromethylornithine (DFMO) and methylglyoxal bis-(guanylhydrazone) (MGBG) were tested against a murine renal adenocarcinoma, because polyamines are necessary for neoplastic cell growth and because human renal adenocarcinomas contain higher levels of spermidine than do normal renal cells; MGBG inhibits spermidine synthesis and has some activity against human renal tumors; DFMO irreversibly inhibits ornithine decarboxylase, the first rate-limiting enzyme controlling polyamine biosynthesis; and DFMO promotes intracellular accumulation of MGBG in experimental tumor models and human leukemia."7.67Effects of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the growth of experimental renal adenocarcinoma in mice. ( Burchenal, JH; Conti, PS; Herr, HW; Kleinert, EL; Whitmore, WF, 1984)
"The effects of human recombinant interferon-alpha 2 (IFN-alpha 2) and alpha-difluoromethylornithine (DFMO) as single agents and in combination were studied for efficacy against the renal cell adenocarcinoma (JDF-1) in an in vitro clonogenic assay and in vivo as xenografts in nude mice."3.67Effects of alpha-difluoromethylornithine and recombinant interferon-alpha 2 on the growth of a human renal cell adenocarcinoma xenograft in nude mice. ( Fleischmann, J; Heston, WD; Ratliff, TL; Tackett, RE, 1984)
"alpha-Difluoromethylornithine (DFMO) and methylglyoxal bis-(guanylhydrazone) (MGBG) were tested against a murine renal adenocarcinoma, because polyamines are necessary for neoplastic cell growth and because human renal adenocarcinomas contain higher levels of spermidine than do normal renal cells; MGBG inhibits spermidine synthesis and has some activity against human renal tumors; DFMO irreversibly inhibits ornithine decarboxylase, the first rate-limiting enzyme controlling polyamine biosynthesis; and DFMO promotes intracellular accumulation of MGBG in experimental tumor models and human leukemia."3.67Effects of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the growth of experimental renal adenocarcinoma in mice. ( Burchenal, JH; Conti, PS; Herr, HW; Kleinert, EL; Whitmore, WF, 1984)
"Difluoromethylornithine (DFMO) and methylglyoxal bis (guanylhydrazone) (MGBG), inhibitors of ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AMDC), respectively, were tested for antitumor activity in the BALB/C mouse renal adenocarcinoma model, wherein ODC and AMDC activity are elevated compared to the normal kidney."3.66Experimental chemotherapy in a transplantable renal adenocarcinoma. I: Effects of some inhibitors of polyamine synthesis. ( Dunzendorfer, U; Kleinert, E; Whitmore, WF, 1983)
"The antiproliferative effects of human recombinant interferon gamma (IFN gamma) in combination with alpha-difluoromethylornithine (DFMO) or as single agents were assessed on human cell cultures derived from carcinomas of the breast (MCF-7), the ovary (EFO-27) or the kidneys (EGI-4)."1.29Antiproliferative effects of interferon gamma in combination with alpha-difluoromethylornithine on human carcinoma cell cultures. ( Hölzel, F; Kirchner, H; Klouche, M, 1994)
"Ethylnitrosourea was given to pregnant rats as a single i."1.28Study of postnatal effects of chemopreventive agents on offspring of ethylnitrosourea-induced transplacental carcinogenesis in rats. I. Influence of retinol acetate, alpha-tocopherol acetate, thiamine chloride, sodium selenite, and alpha-difluoromethylorn ( Alexandrov, VA; Bespalov, VG; Boone, CW; Kelloff, GJ; Malone, WF, 1991)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-199012 (85.71)18.7374
1990's2 (14.29)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dunzendorfer, U3
Warrell, RP1
Burchenal, JH2
Kingsnorth, AN2
McCann, PP1
Diekema, KA1
Ross, JS2
Malt, RA2
Kleinert, E1
Whitmore, WF2
Heston, WD2
Fleischmann, J2
Tackett, RE1
Ratliff, TL2
Herr, HW1
Kleinert, EL1
Conti, PS1
Klouche, M1
Kirchner, H1
Hölzel, F1
Alexandrov, VA1
Bespalov, VG1
Boone, CW1
Kelloff, GJ1
Malone, WF1
Pine, MJ1
Huben, RP1
Pegg, AE1
Gohji, K2
Murao, S1
Maeda, S1
Sugiyama, T1
Kamidono, S2
Bander, NH1
Bauer, WC1
Janney, C1
Fair, WR1
Lamuraglia, GM1
Lacaine, F1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Urinary Excretion of Acetylamantadine by Cancer Patients[NCT02277938]120 participants (Anticipated)Observational2013-08-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for eflornithine and Kidney Neoplasms

ArticleYear
Methylglyoxal-bis(guanylhydrazone) (Methyl-GAG): current status and future prospects.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1983, Volume: 1, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemical Phenomena; Chemistry; Clinical Tri

1983
Chemoprevention and chemotherapy by inhibition of ornithine decarboxylase activity and polyamine synthesis: colonic, pancreatic, mammary, and renal carcinomas.
    Advances in enzyme regulation, 1985, Volume: 24

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Division; Colonic Neoplasms; Eflornithine; Fe

1985

Trials

1 trial available for eflornithine and Kidney Neoplasms

ArticleYear
Methylglyoxal-bis(guanylhydrazone) (Methyl-GAG): current status and future prospects.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1983, Volume: 1, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemical Phenomena; Chemistry; Clinical Tri

1983

Other Studies

12 other studies available for eflornithine and Kidney Neoplasms

ArticleYear
The effect of alpha-difluoromethyl-ornithine on tumor growth, acute phase reactants, beta-2-microglobulin and hydroxyproline in kidney and bladder carcinomas.
    Urologia internationalis, 1981, Volume: 36, Issue:2

    Topics: 17-Ketosteroids; Adenocarcinoma; Adult; Aged; alpha 1-Antitrypsin; Antineoplastic Agents; beta 2-Mic

1981
Effects of alpha-difluoromethylornithine on the growth of experimental Wilms' tumor and renal adenocarcinoma.
    Cancer research, 1983, Volume: 43, Issue:9

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Drug Evaluation, Preclinical; Eflornithine; Kidney N

1983
Experimental chemotherapy in a transplantable renal adenocarcinoma. I: Effects of some inhibitors of polyamine synthesis.
    Urologia internationalis, 1983, Volume: 38, Issue:3

    Topics: Adenocarcinoma; Animals; Eflornithine; Guanidines; Kidney; Kidney Neoplasms; Mice; Mice, Inbred BALB

1983
Effects of alpha-difluoromethylornithine and recombinant interferon-alpha 2 on the growth of a human renal cell adenocarcinoma xenograft in nude mice.
    Cancer research, 1984, Volume: 44, Issue:8

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Cell Line; Clone Cells; Drug Synergis

1984
Effects of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the growth of experimental renal adenocarcinoma in mice.
    Cancer research, 1984, Volume: 44, Issue:10

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Body Weight; Cell Division; Drug Synergism; Eflornit

1984
Antiproliferative effects of interferon gamma in combination with alpha-difluoromethylornithine on human carcinoma cell cultures.
    Journal of cancer research and clinical oncology, 1994, Volume: 120, Issue:12

    Topics: Breast Neoplasms; Cell Division; Drug Synergism; Eflornithine; Female; Growth Inhibitors; Humans; In

1994
Study of postnatal effects of chemopreventive agents on offspring of ethylnitrosourea-induced transplacental carcinogenesis in rats. I. Influence of retinol acetate, alpha-tocopherol acetate, thiamine chloride, sodium selenite, and alpha-difluoromethylorn
    Cancer letters, 1991, Volume: 60, Issue:2

    Topics: alpha-Tocopherol; Animals; Antioxidants; Diterpenes; Eflornithine; Ethylnitrosourea; Female; Kidney

1991
Production of N1-acetyl spermidine by renal cell tumors.
    The Journal of urology, 1989, Volume: 141, Issue:3

    Topics: Animals; Carcinoma, Renal Cell; Carmustine; Eflornithine; Female; Kidney Neoplasms; Mice; Mice, Inbr

1989
Enhanced inhibition of colony formation of human renal cell carcinoma in soft agar by the combination of alpha-difluoromethylornithine and recombinant gamma-interferon.
    Cancer research, 1986, Volume: 46, Issue:12 Pt 1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cells, Cultured; Eflornithine

1986
[Study on anticancer chemotherapy of human renal cell carcinoma. The combined effect of interferon and other anticancer drugs].
    Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 1987, Volume: 78, Issue:6

    Topics: Antineoplastic Agents; Carcinoma, Renal Cell; Combined Modality Therapy; Eflornithine; Humans; Inter

1987
Human renal cell carcinoma xenograft: morphology, growth and chemosensitivities.
    The Journal of urology, 1985, Volume: 134, Issue:3

    Topics: Aged; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Antineoplastic Agents; Antineoplastic Com

1985
[Polyamines, polyamine antimetabolites and urogenital tumors. State of research and clinical results].
    Urologia internationalis, 1985, Volume: 40, Issue:5

    Topics: Adenosylmethionine Decarboxylase; Antimetabolites, Antineoplastic; Carboxy-Lyases; Drug Combinations

1985