eflornithine has been researched along with Keratosis in 3 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Keratosis: Any horny growth such as a wart or callus.
| Excerpt | Relevance | Reference |
|---|---|---|
| "More than one million new skin cancers are diagnosed yearly in the United States creating the need for effective primary and chemopreventive strategies to reduce the incidence, morbidity, and mortality associated with skin cancer." | 2.70 | Modulation of biologic endpoints by topical difluoromethylornithine (DFMO), in subjects at high-risk for nonmelanoma skin cancer. ( Alberts, DS; Bowden, GT; Einspahr, JG; Nelson, MA; Saboda, K; Warneke, J, 2002) |
| "4%) inflammatory reactions on their DFMO-treated arms which required dosing modification." | 2.69 | Chemoprevention of human actinic keratoses by topical 2-(difluoromethyl)-dl-ornithine. ( Aickin, M; Alberts, DS; Bowden, GT; Dorr, RT; Einspahr, JG; Foote, JA; Goldman, R; Peng, YM; Roe, DJ; Saboda, K; Salasche, S; Warneke, JA; Xu, MJ, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alberts, DS | 3 |
| Dorr, RT | 1 |
| Einspahr, JG | 2 |
| Aickin, M | 1 |
| Saboda, K | 2 |
| Xu, MJ | 1 |
| Peng, YM | 1 |
| Goldman, R | 1 |
| Foote, JA | 1 |
| Warneke, JA | 1 |
| Salasche, S | 1 |
| Roe, DJ | 1 |
| Bowden, GT | 2 |
| Bozzo, P | 1 |
| Vaught, L | 1 |
| da Silva, VD | 1 |
| Thompson, D | 1 |
| Warnecke, J | 1 |
| Miller, RC | 1 |
| Einspahr, J | 1 |
| Bartels, PH | 1 |
| Nelson, MA | 1 |
| Warneke, J | 1 |
2 trials available for eflornithine and Keratosis
| Article | Year |
|---|---|
Chemoprevention of human actinic keratoses by topical 2-(difluoromethyl)-dl-ornithine.
Topics: Aged; Antineoplastic Agents; Eflornithine; Enzyme Inhibitors; Female; Humans; Keratosis; Male; Ointm | 2000 |
Modulation of biologic endpoints by topical difluoromethylornithine (DFMO), in subjects at high-risk for nonmelanoma skin cancer.
Topics: Aged; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Biopsy; Cell Division; Eflornithine; Enzy | 2002 |
1 other study available for eflornithine and Keratosis
| Article | Year |
|---|---|
Measurement of chemopreventive efficacy in skin biopsies.
Topics: Antineoplastic Agents; Biopsy; Cell Nucleus; Eflornithine; Humans; Image Interpretation, Computer-As | 2001 |