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eflornithine and Invasiveness, Neoplasm

eflornithine has been researched along with Invasiveness, Neoplasm in 15 studies

Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.

Research Excerpts

ExcerptRelevanceReference
"Our previous study showed that treatment of highly invasive rat ascites hepatoma (LC-AH) cells with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, decreased both their intracellular level of putrescine and their in vitro invasion of a monolayer of calf pulmonary arterial endothelial (CPAE) cells, and that both these decreases were completely reversed by exogenous putrescine, but not spermidine or spermine."7.70Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells. ( Ashida, Y; Inoue, H; Miwa, Y; Miyoshi, K; Ueno, A, 1998)
"Our previous study showed that treatment of highly invasive rat ascites hepatoma (LC-AH) cells with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, decreased both their intracellular level of putrescine and their in vitro invasion of a monolayer of calf pulmonary arterial endothelial (CPAE) cells, and that both these decreases were completely reversed by exogenous putrescine, but not spermidine or spermine."3.70Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells. ( Ashida, Y; Inoue, H; Miwa, Y; Miyoshi, K; Ueno, A, 1998)
" Treatment of cells with a second inhibitor of polyamine biosynthesis, the S-adenosylmethionine decarboxylase (SAMDC) inhibitor SAM486A, also resulted in a dosage dependent decrease in meprin alpha and MMP-7 mRNA."1.33Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells. ( Bond, JS; Manni, A; Matters, GL, 2005)
"Since bladder tumors in rats are of low grade and superficial whereas those in mice are of high grade and deeply invasive, our data indicate that DFMO has little to no effects against the development of aggressive forms of bladder carcinoma."1.28Effects of alpha-difluromethylornithine on the development of deeply invasive urinary bladder carcinomas in mice. ( Oyasu, R; Samma, S; Seidenfeld, J; Uchida, K, 1990)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (46.67)18.2507
2000's6 (40.00)29.6817
2010's2 (13.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Koomoa, DL1
Geerts, D1
Lange, I1
Koster, J1
Pegg, AE2
Feith, DJ1
Bachmann, AS1
Izbicka, E1
Streeper, RT1
Yeh, IT1
Pressley, O1
Grant, M1
Andrews, JV1
Kuhn, J1
O'Shaughnessy, J1
Manni, A6
Washington, S5
Mauger, D3
Hackett, DA1
Verderame, MF5
Hu, X1
Griffith, JW2
Bruggeman, R1
Demers, LM2
Matters, GL1
Bond, JS1
Xu, H2
Deen, DF2
Chiarodo, A1
Grimm, EA1
Fike, JR1
Israel, MA1
Kun, LE1
Levin, VA1
Marton, LJ1
Packer, RJ1
Ashida, Y2
Ueno, A1
Miwa, Y1
Miyoshi, K1
Inoue, H2
Terzis, AJ1
Pedersen, PH1
Feuerstein, BG1
Arnold, H1
Bjerkvig, R1
Boiko, IV1
Mitchell, MF1
Hu, W1
Pandey, DK1
Mathevet, P1
Malpica, A1
Hittelman, WN1
Samant, RS1
Welch, DR1
Loprinzi, CL1
Messing, EM1
Kido, J1
Kinoshita, F1
Nishino, M1
Shinkai, K1
Akedo, H1
Samma, S1
Uchida, K1
Seidenfeld, J1
Oyasu, R1

Reviews

1 review available for eflornithine and Invasiveness, Neoplasm

ArticleYear
A prospective clinical trial of difluoromethylornithine (DFMO) in patients with resected superficial bladder cancer.
    Journal of cellular biochemistry. Supplement, 1992, Volume: 16I

    Topics: Clinical Trials as Topic; Eflornithine; Humans; Neoplasm Invasiveness; Neoplasm Recurrence, Local; N

1992

Other Studies

14 other studies available for eflornithine and Invasiveness, Neoplasm

ArticleYear
DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma.
    International journal of oncology, 2013, Volume: 42, Issue:4

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Child, Preschool; Cyclin-Dependent Kinase In

2013
Effects of alpha-difluoromethylornithine on markers of proliferation, invasion, and apoptosis in breast cancer.
    Anticancer research, 2010, Volume: 30, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Intraductal, Nonin

2010
Cellular mechanisms mediating the anti-invasive properties of the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO) in human breast cancer cells.
    Clinical & experimental metastasis, 2004, Volume: 21, Issue:5

    Topics: Breast Neoplasms; Eflornithine; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; Mit

2004
Effects of polyamine synthesis inhibitors on primary tumor features and metastatic capacity of human breast cancer cells.
    Clinical & experimental metastasis, 2005, Volume: 22, Issue:3

    Topics: Amidines; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cell Proli

2005
Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells.
    Clinical & experimental metastasis, 2005, Volume: 22, Issue:4

    Topics: Amidines; Antineoplastic Agents; Breast Neoplasms; Down-Regulation; Eflornithine; Enzyme Inhibitors;

2005
Activation of protein kinase A (PKA) signaling mitigates the antiproliferative and antiinvasive effects of alpha-difluoromethylornithine in breast cancer cells.
    Breast cancer research and treatment, 2008, Volume: 107, Issue:1

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclic AMP-Dependent Protein Kinases; Eflorn

2008
Role of non-receptor and receptor tyrosine kinases (TKs) in the antitumor action of alpha-difluoromethylornithine (DFMO) in breast cancer cells.
    Breast cancer research and treatment, 2008, Volume: 112, Issue:2

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Eflornithine; Hepatocyte Growth Factor;

2008
Brain Tumor Working Group Report on the 9th International Conference on Brain Tumor Research and Therapy. Organ System Program, National Cancer Institute.
    Journal of neuro-oncology, 1993, Volume: 16, Issue:3

    Topics: Adult; Animals; Antineoplastic Agents; Brain Neoplasms; Child; Child, Preschool; Clinical Trials as

1993
Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells.
    Japanese journal of cancer research : Gann, 1998, Volume: 89, Issue:1

    Topics: Animals; Ascites; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Carcinoma, Hepatocell

1998
Effects of DFMO on glioma cell proliferation, migration and invasion in vitro.
    Journal of neuro-oncology, 1998, Volume: 36, Issue:2

    Topics: Adult; Animals; Antineoplastic Agents; Cell Division; Cell Movement; Eflornithine; Female; Glioma; H

1998
Epidermal growth factor receptor expression in cervical intraepithelial neoplasia and its modulation during an alpha-difluoromethylornithine chemoprevention trial.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:6

    Topics: Anticarcinogenic Agents; Antineoplastic Agents; Biomarkers; Cervix Uteri; Disease Progression; Eflor

1998
Influence of polyamines on in vitro and in vivo features of aggressive and metastatic behavior by human breast cancer cells.
    Clinical & experimental metastasis, 2002, Volume: 19, Issue:2

    Topics: Animals; Biogenic Polyamines; Blotting, Northern; Breast Neoplasms; Collagen; Dose-Response Relation

2002
Putrescine-dependent invasive capacity of rat ascites hepatoma cells.
    Cancer research, 1992, Oct-01, Volume: 52, Issue:19

    Topics: Animals; Ascites; Biogenic Polyamines; Cattle; Cells, Cultured; Eflornithine; Endothelium, Vascular;

1992
Effects of alpha-difluromethylornithine on the development of deeply invasive urinary bladder carcinomas in mice.
    Urological research, 1990, Volume: 18, Issue:4

    Topics: Animals; Butylhydroxybutylnitrosamine; Eflornithine; Male; Mice; Mice, Inbred C3H; Neoplasm Invasive

1990