eflornithine has been researched along with Invasiveness, Neoplasm in 15 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our previous study showed that treatment of highly invasive rat ascites hepatoma (LC-AH) cells with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, decreased both their intracellular level of putrescine and their in vitro invasion of a monolayer of calf pulmonary arterial endothelial (CPAE) cells, and that both these decreases were completely reversed by exogenous putrescine, but not spermidine or spermine." | 7.70 | Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells. ( Ashida, Y; Inoue, H; Miwa, Y; Miyoshi, K; Ueno, A, 1998) |
| "Our previous study showed that treatment of highly invasive rat ascites hepatoma (LC-AH) cells with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, decreased both their intracellular level of putrescine and their in vitro invasion of a monolayer of calf pulmonary arterial endothelial (CPAE) cells, and that both these decreases were completely reversed by exogenous putrescine, but not spermidine or spermine." | 3.70 | Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells. ( Ashida, Y; Inoue, H; Miwa, Y; Miyoshi, K; Ueno, A, 1998) |
| " Treatment of cells with a second inhibitor of polyamine biosynthesis, the S-adenosylmethionine decarboxylase (SAMDC) inhibitor SAM486A, also resulted in a dosage dependent decrease in meprin alpha and MMP-7 mRNA." | 1.33 | Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells. ( Bond, JS; Manni, A; Matters, GL, 2005) |
| "Since bladder tumors in rats are of low grade and superficial whereas those in mice are of high grade and deeply invasive, our data indicate that DFMO has little to no effects against the development of aggressive forms of bladder carcinoma." | 1.28 | Effects of alpha-difluromethylornithine on the development of deeply invasive urinary bladder carcinomas in mice. ( Oyasu, R; Samma, S; Seidenfeld, J; Uchida, K, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (46.67) | 18.2507 |
| 2000's | 6 (40.00) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koomoa, DL | 1 |
| Geerts, D | 1 |
| Lange, I | 1 |
| Koster, J | 1 |
| Pegg, AE | 2 |
| Feith, DJ | 1 |
| Bachmann, AS | 1 |
| Izbicka, E | 1 |
| Streeper, RT | 1 |
| Yeh, IT | 1 |
| Pressley, O | 1 |
| Grant, M | 1 |
| Andrews, JV | 1 |
| Kuhn, J | 1 |
| O'Shaughnessy, J | 1 |
| Manni, A | 6 |
| Washington, S | 5 |
| Mauger, D | 3 |
| Hackett, DA | 1 |
| Verderame, MF | 5 |
| Hu, X | 1 |
| Griffith, JW | 2 |
| Bruggeman, R | 1 |
| Demers, LM | 2 |
| Matters, GL | 1 |
| Bond, JS | 1 |
| Xu, H | 2 |
| Deen, DF | 2 |
| Chiarodo, A | 1 |
| Grimm, EA | 1 |
| Fike, JR | 1 |
| Israel, MA | 1 |
| Kun, LE | 1 |
| Levin, VA | 1 |
| Marton, LJ | 1 |
| Packer, RJ | 1 |
| Ashida, Y | 2 |
| Ueno, A | 1 |
| Miwa, Y | 1 |
| Miyoshi, K | 1 |
| Inoue, H | 2 |
| Terzis, AJ | 1 |
| Pedersen, PH | 1 |
| Feuerstein, BG | 1 |
| Arnold, H | 1 |
| Bjerkvig, R | 1 |
| Boiko, IV | 1 |
| Mitchell, MF | 1 |
| Hu, W | 1 |
| Pandey, DK | 1 |
| Mathevet, P | 1 |
| Malpica, A | 1 |
| Hittelman, WN | 1 |
| Samant, RS | 1 |
| Welch, DR | 1 |
| Loprinzi, CL | 1 |
| Messing, EM | 1 |
| Kido, J | 1 |
| Kinoshita, F | 1 |
| Nishino, M | 1 |
| Shinkai, K | 1 |
| Akedo, H | 1 |
| Samma, S | 1 |
| Uchida, K | 1 |
| Seidenfeld, J | 1 |
| Oyasu, R | 1 |
1 review available for eflornithine and Invasiveness, Neoplasm
| Article | Year |
|---|---|
A prospective clinical trial of difluoromethylornithine (DFMO) in patients with resected superficial bladder cancer.
Topics: Clinical Trials as Topic; Eflornithine; Humans; Neoplasm Invasiveness; Neoplasm Recurrence, Local; N | 1992 |
14 other studies available for eflornithine and Invasiveness, Neoplasm
| Article | Year |
|---|---|
DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Child, Preschool; Cyclin-Dependent Kinase In | 2013 |
Effects of alpha-difluoromethylornithine on markers of proliferation, invasion, and apoptosis in breast cancer.
Topics: Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Intraductal, Nonin | 2010 |
Cellular mechanisms mediating the anti-invasive properties of the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO) in human breast cancer cells.
Topics: Breast Neoplasms; Eflornithine; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; Mit | 2004 |
Effects of polyamine synthesis inhibitors on primary tumor features and metastatic capacity of human breast cancer cells.
Topics: Amidines; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cell Proli | 2005 |
Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells.
Topics: Amidines; Antineoplastic Agents; Breast Neoplasms; Down-Regulation; Eflornithine; Enzyme Inhibitors; | 2005 |
Activation of protein kinase A (PKA) signaling mitigates the antiproliferative and antiinvasive effects of alpha-difluoromethylornithine in breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclic AMP-Dependent Protein Kinases; Eflorn | 2008 |
Role of non-receptor and receptor tyrosine kinases (TKs) in the antitumor action of alpha-difluoromethylornithine (DFMO) in breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Eflornithine; Hepatocyte Growth Factor; | 2008 |
Brain Tumor Working Group Report on the 9th International Conference on Brain Tumor Research and Therapy. Organ System Program, National Cancer Institute.
Topics: Adult; Animals; Antineoplastic Agents; Brain Neoplasms; Child; Child, Preschool; Clinical Trials as | 1993 |
Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells.
Topics: Animals; Ascites; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Carcinoma, Hepatocell | 1998 |
Effects of DFMO on glioma cell proliferation, migration and invasion in vitro.
Topics: Adult; Animals; Antineoplastic Agents; Cell Division; Cell Movement; Eflornithine; Female; Glioma; H | 1998 |
Epidermal growth factor receptor expression in cervical intraepithelial neoplasia and its modulation during an alpha-difluoromethylornithine chemoprevention trial.
Topics: Anticarcinogenic Agents; Antineoplastic Agents; Biomarkers; Cervix Uteri; Disease Progression; Eflor | 1998 |
Influence of polyamines on in vitro and in vivo features of aggressive and metastatic behavior by human breast cancer cells.
Topics: Animals; Biogenic Polyamines; Blotting, Northern; Breast Neoplasms; Collagen; Dose-Response Relation | 2002 |
Putrescine-dependent invasive capacity of rat ascites hepatoma cells.
Topics: Animals; Ascites; Biogenic Polyamines; Cattle; Cells, Cultured; Eflornithine; Endothelium, Vascular; | 1992 |
Effects of alpha-difluromethylornithine on the development of deeply invasive urinary bladder carcinomas in mice.
Topics: Animals; Butylhydroxybutylnitrosamine; Eflornithine; Male; Mice; Mice, Inbred C3H; Neoplasm Invasive | 1990 |