eflornithine has been researched along with Intestinal Neoplasms in 11 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Intestinal Neoplasms: Tumors or cancer of the INTESTINES.
| Excerpt | Relevance | Reference |
|---|---|---|
| " These COX-2 and ODC inhibitor drugs were not overtly toxic at the doses used when administered to mice after weaning." | 5.31 | Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas, and selective toxicity against Apc mutant embryos. ( Cole, CE; Hawk, ET; Jacoby, RF; Kelloff, G; Lubet, RA; Newton, MA; Tutsch, K, 2000) |
| "The majority of colon cancers have somatic mutations in the APC (adenomatous polyposis coli) tumour-suppressor gene." | 1.34 | Impact of dietary amino acids and polyamines on intestinal carcinogenesis and chemoprevention in mouse models. ( Gerner, EW, 2007) |
| " These COX-2 and ODC inhibitor drugs were not overtly toxic at the doses used when administered to mice after weaning." | 1.31 | Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas, and selective toxicity against Apc mutant embryos. ( Cole, CE; Hawk, ET; Jacoby, RF; Kelloff, G; Lubet, RA; Newton, MA; Tutsch, K, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ignatenko, NA | 2 |
| Besselsen, DG | 1 |
| Stringer, DE | 1 |
| Blohm-Mangone, KA | 2 |
| Cui, H | 1 |
| Gerner, EW | 4 |
| Rial, NS | 1 |
| Meyskens, FL | 1 |
| Erdman, SH | 1 |
| Powell, MB | 1 |
| Holubec, H | 1 |
| Guillén-Rodriguez, JM | 1 |
| Halberg, RB | 1 |
| Katzung, DS | 1 |
| Hoff, PD | 1 |
| Moser, AR | 1 |
| Cole, CE | 2 |
| Lubet, RA | 2 |
| Donehower, LA | 1 |
| Jacoby, RF | 2 |
| Dove, WF | 1 |
| Tutsch, K | 1 |
| Newton, MA | 1 |
| Kelloff, G | 3 |
| Hawk, ET | 1 |
| Takeshita, S | 1 |
| Nagatomi, H | 1 |
| Ando, K | 1 |
| Rao, CV | 1 |
| Tokumo, K | 2 |
| Rigotty, J | 2 |
| Zang, E | 2 |
| Reddy, BS | 2 |
| Nayini, J | 1 |
| Nigro, ND | 2 |
| Bull, AW | 2 |
| Boyd, ME | 2 |
1 review available for eflornithine and Intestinal Neoplasms
| Article | Year |
|---|---|
Polyamines as mediators of APC-dependent intestinal carcinogenesis and cancer chemoprevention.
Topics: Adenomatous Polyposis Coli Protein; Animals; Clinical Trials as Topic; Eflornithine; Genetic Predisp | 2009 |
10 other studies available for eflornithine and Intestinal Neoplasms
| Article | Year |
|---|---|
Combination chemoprevention of intestinal carcinogenesis in a murine model of familial adenomatous polyposis.
Topics: Adenoma; Adenomatous Polyposis Coli; Animals; Biogenic Polyamines; Celecoxib; Chemoprevention; Eflor | 2008 |
Impact of dietary amino acids and polyamines on intestinal carcinogenesis and chemoprevention in mouse models.
Topics: Amino Acids; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Colonic Neoplasms; Diet; Disea | 2007 |
APC-dependent changes in expression of genes influencing polyamine metabolism, and consequences for gastrointestinal carcinogenesis, in the Min mouse.
Topics: Acetyltransferases; Animals; Anticarcinogenic Agents; Colon; Colonic Neoplasms; Eflornithine; Gene E | 1999 |
Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers.
Topics: Adenoma; Animals; Eflornithine; Female; Fibromatosis, Aggressive; Genes, APC; Genes, p53; Intestinal | 2000 |
Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas, and selective toxicity against Apc mutant embryos.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhi | 2000 |
Alleviation of intestinal lesions by combined treatment with a 5-fluoro-2'-deoxyuridine (FUDR) derivative and alpha-difluoromethylornithine (DFMO)[correction of DMFO] in tumor-bearing mice.
Topics: Amine Oxidase (Copper-Containing); Animals; Antineoplastic Combined Chemotherapy Protocols; Body Wei | 1992 |
Chemoprevention of colon carcinogenesis by dietary administration of piroxicam, alpha-difluoromethylornithine, 16 alpha-fluoro-5-androsten-17-one, and ellagic acid individually and in combination.
Topics: Animals; Body Weight; Colonic Neoplasms; Dehydroepiandrosterone; Drug Combinations; Drug Evaluation, | 1991 |
Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal antiinflammatory drug with D,L-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor, in diet.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Colonic Neopla | 1990 |
Inhibition of intestinal carcinogenesis in rats: effect of difluoromethylornithine with piroxicam or fish oil.
Topics: Animals; Body Weight; Diet; Drinking; Eating; Eflornithine; Fish Oils; Intestinal Neoplasms; Male; P | 1986 |
Importance of the duration of inhibition on intestinal carcinogenesis by difluoromethylornithine in rats.
Topics: Animals; Azo Compounds; Azoxymethane; Body Weight; Drinking; Eating; Eflornithine; Intestinal Neopla | 1987 |