eflornithine has been researched along with Insulinoma in 4 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Insulinoma: A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sjöholm, A | 3 |
| Arkhammar, P | 1 |
| Welsh, N | 2 |
| Bokvist, K | 1 |
| Rorsman, P | 1 |
| Hallberg, A | 1 |
| Nilsson, T | 1 |
| Welsh, M | 1 |
| Berggren, PO | 1 |
| Honkanen, RE | 1 |
| Camara, J | 1 |
| Galera, C | 1 |
| Valverde, I | 1 |
| Malaisse, WJ | 1 |
| Hoftiezer, V | 1 |
| Bankston, PW | 1 |
| Hellerström, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563] | Phase 2 | 70 participants (Anticipated) | Interventional | 2023-03-14 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for eflornithine and Insulinoma
| Article | Year |
|---|---|
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Ne | 1993 |
Polyamines regulate serine/threonine protein phosphatases in insulin-secreting cells.
Topics: Arginine; Eflornithine; Enzyme Activation; Enzyme Inhibitors; Histones; Humans; Insulin; Insulin Sec | 2000 |
Relationship between D-glucose oxidation and glycolysis in tumoral pancreatic islet cells with either rapid or decreased cell growth.
Topics: Animals; Carbon Dioxide; Carbon Radioisotopes; Cell Division; Cell Line; Citric Acid Cycle; Eflornit | 1991 |
Increased glucose oxidation and contents of insulin and ATP in polyamine-depleted rat insulinoma cells (RINm5F).
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Line; Cytoplasmic Granules; Eflornithin | 1991 |