Page last updated: 2024-10-25

eflornithine and Insulinoma

eflornithine has been researched along with Insulinoma in 4 studies

Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.

Insulinoma: A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (75.00)18.2507
2000's1 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sjöholm, A3
Arkhammar, P1
Welsh, N2
Bokvist, K1
Rorsman, P1
Hallberg, A1
Nilsson, T1
Welsh, M1
Berggren, PO1
Honkanen, RE1
Camara, J1
Galera, C1
Valverde, I1
Malaisse, WJ1
Hoftiezer, V1
Bankston, PW1
Hellerström, C1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563]Phase 270 participants (Anticipated)Interventional2023-03-14Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

4 other studies available for eflornithine and Insulinoma

ArticleYear
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
    The Journal of clinical investigation, 1993, Volume: 92, Issue:4

    Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Ne

1993
Polyamines regulate serine/threonine protein phosphatases in insulin-secreting cells.
    Pancreas, 2000, Volume: 20, Issue:1

    Topics: Arginine; Eflornithine; Enzyme Activation; Enzyme Inhibitors; Histones; Humans; Insulin; Insulin Sec

2000
Relationship between D-glucose oxidation and glycolysis in tumoral pancreatic islet cells with either rapid or decreased cell growth.
    Diabetes research (Edinburgh, Scotland), 1991, Volume: 17, Issue:2

    Topics: Animals; Carbon Dioxide; Carbon Radioisotopes; Cell Division; Cell Line; Citric Acid Cycle; Eflornit

1991
Increased glucose oxidation and contents of insulin and ATP in polyamine-depleted rat insulinoma cells (RINm5F).
    The Biochemical journal, 1991, Jul-15, Volume: 277 ( Pt 2)

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Line; Cytoplasmic Granules; Eflornithin

1991