eflornithine has been researched along with Inflammation in 5 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Excerpt | Relevance | Reference |
---|---|---|
"Up-regulation of arginase contributes to airways hyperresponsiveness (AHR) in asthma by reducing L-arginine bioavailability for the nitric oxide (NO) synthase isozymes." | 5.39 | Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma. ( Gauvreau, GM; Grasemann, H; Inman, MD; Khanna, N; North, ML; Scott, JA, 2013) |
"Up-regulation of arginase contributes to airways hyperresponsiveness (AHR) in asthma by reducing L-arginine bioavailability for the nitric oxide (NO) synthase isozymes." | 1.39 | Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma. ( Gauvreau, GM; Grasemann, H; Inman, MD; Khanna, N; North, ML; Scott, JA, 2013) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (20.00) | 18.2507 |
2000's | 2 (40.00) | 29.6817 |
2010's | 2 (40.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
North, ML | 1 |
Grasemann, H | 1 |
Khanna, N | 1 |
Inman, MD | 1 |
Gauvreau, GM | 1 |
Scott, JA | 1 |
Rial, NS | 1 |
Meyskens, FL | 1 |
Gerner, EW | 1 |
Silva, MA | 1 |
Klafke, JZ | 1 |
Rossato, MF | 1 |
Gewehr, C | 1 |
Guerra, GP | 1 |
Rubin, MA | 1 |
Ferreira, J | 1 |
Chen, X | 1 |
Li, N | 1 |
Wang, S | 1 |
Hong, J | 1 |
Fang, M | 1 |
Yousselfson, J | 1 |
Yang, P | 1 |
Newman, RA | 1 |
Lubet, RA | 1 |
Yang, CS | 1 |
Tjandrawinata, RR | 1 |
Hawel, L | 1 |
Byus, CV | 1 |
1 review available for eflornithine and Inflammation
Article | Year |
---|---|
Polyamines as mediators of APC-dependent intestinal carcinogenesis and cancer chemoprevention.
Topics: Adenomatous Polyposis Coli Protein; Animals; Clinical Trials as Topic; Eflornithine; Genetic Predisp | 2009 |
4 other studies available for eflornithine and Inflammation
Article | Year |
---|---|
Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma.
Topics: Adolescent; Adult; Animals; Asthma; Disease Models, Animal; Eflornithine; Female; Humans; Hypersensi | 2013 |
Role of peripheral polyamines in the development of inflammatory pain.
Topics: Animals; Eflornithine; Gene Expression Regulation, Enzymologic; Indoles; Inflammation; Male; Maleimi | 2011 |
Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonic Acid; Body Weight; Cyclooxygenase 2 | 2002 |
Regulation of putrescine export in lipopolysaccharide or IFN-gamma-activated murine monocytic-leukemic RAW 264 cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; DNA; Dose-Response Relationship, Drug; Eflornithine | 1994 |