eflornithine has been researched along with Hypertrophy in 15 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Hypertrophy: General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lung putrescine levels were increased from days 7 through 21, and both spermidine and spermine were first elevated at day 10 following MCT administration." | 5.27 | Polyamines and the development of monocrotaline-induced pulmonary hypertension. ( Altiere, RJ; Gillespie, MN; Hacker, AD; Olson, JW, 1984) |
| "Administration of testosterone to female mice causes hypertrophy of their kidneys with spectacular induction of ornithine decarboxylase and significant increase in the level of putrescine." | 3.69 | Arginine and ornithine metabolizing enzymes in testosterone-induced hypertrophic mouse kidney. ( Chmurzyńska, W; Grzelakowska-Sztabert, B; Manteuffel-Cymborowska, M; Peska, M, 1995) |
| "The transient hypertrophy of the denervated rat hemidiaphragm is associated with a rise in concentrations of putrescine and spermidine." | 3.67 | Role of polyamines and intracellular pH change in the hypertrophy of the denervated rat hemidiaphragm. ( Manchester, KL; Marais, A, 1988) |
| "Lung putrescine levels were increased from days 7 through 21, and both spermidine and spermine were first elevated at day 10 following MCT administration." | 1.27 | Polyamines and the development of monocrotaline-induced pulmonary hypertension. ( Altiere, RJ; Gillespie, MN; Hacker, AD; Olson, JW, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (26.67) | 18.7374 |
| 1990's | 7 (46.67) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cetrullo, S | 1 |
| Facchini, A | 1 |
| Stanic, I | 1 |
| Tantini, B | 1 |
| Pignatti, C | 1 |
| Caldarera, CM | 1 |
| Flamigni, F | 1 |
| Satriano, J | 2 |
| Bartolome, JV | 1 |
| Olson, JW | 1 |
| Hacker, AD | 1 |
| Altiere, RJ | 1 |
| Gillespie, MN | 1 |
| Tovar, A | 1 |
| Sánchez-Capelo, A | 1 |
| Cremades, A | 1 |
| Peñafiel, R | 1 |
| Manteuffel-Cymborowska, M | 3 |
| Chmurzyńska, W | 3 |
| Peska, M | 2 |
| Grzelakowska-Sztabert, B | 3 |
| Pedersen, SB | 2 |
| Bjørn, SF | 1 |
| Richelsen, B | 2 |
| Flyvbjerg, A | 2 |
| Nilsson, BO | 1 |
| Lindqvist, A | 1 |
| Pandita, RK | 1 |
| Swärd, K | 1 |
| Persson, K | 1 |
| Hostetter, TH | 1 |
| Thomson, SC | 1 |
| Deng, A | 1 |
| Bao, D | 1 |
| Blantz, RC | 1 |
| Vallon, V | 1 |
| Marais, A | 1 |
| Manchester, KL | 1 |
| Humphreys, MH | 1 |
| Etheredge, SB | 1 |
| Lin, SY | 1 |
| Ribstein, J | 1 |
| Marton, LJ | 1 |
1 review available for eflornithine and Hypertrophy
| Article | Year |
|---|---|
Kidney growth, hypertrophy and the unifying mechanism of diabetic complications.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; Cell Cycle Proteins; Cyclin-Depende | 2007 |
14 other studies available for eflornithine and Hypertrophy
| Article | Year |
|---|---|
Difluoromethylornithine inhibits hypertrophic, pro-fibrotic and pro-apoptotic actions of aldosterone in cardiac cells.
Topics: Aldosterone; Animals; Apoptosis; Biogenic Polyamines; Cells, Cultured; Eflornithine; Fibrosis; Gene | 2010 |
Neonatal methyl mercury exposure: biochemical mechanisms in the developing kidney.
Topics: Animals; Animals, Newborn; Eflornithine; Hypertrophy; Kidney; Methylmercury Compounds; Organ Size; O | 1983 |
Polyamines and the development of monocrotaline-induced pulmonary hypertension.
Topics: Adenosylmethionine Decarboxylase; Animals; Blood Pressure; Eflornithine; Heart Ventricles; Hypertens | 1984 |
An evaluation of the role of polyamines in different models of kidney hypertrophy in mice.
Topics: Alloxan; Animals; Biogenic Polyamines; Diabetes Mellitus, Experimental; Eflornithine; Female; Hypert | 1995 |
Arginine and ornithine metabolizing enzymes in testosterone-induced hypertrophic mouse kidney.
Topics: Animals; Arginase; Arginine; Eflornithine; Enzyme Induction; Female; Folic Acid; Hypertrophy; Kidney | 1995 |
Inhibition of renal ornithine decarboxylase activity fails to reduce kidney size and urinary albumin excretion in diabetic rats with manifest kidney hypertrophy.
Topics: Albuminuria; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diuresis; Eflorni | 1995 |
Polyamines in testosterone-induced hypertrophic and antifolate-induced hyperplastic mouse kidney. Differential effect of alpha-difluoromethylornithine.
Topics: Animals; Eflornithine; Female; Folic Acid; Hyperplasia; Hypertrophy; Kidney; Kidney Diseases; Mice; | 1993 |
Inhibition of renal ornithine decarboxylase activity prevents kidney hypertrophy in experimental diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Eflornithine; Hypertrophy; Insulin; Kidney; Male; Organ Si | 1993 |
Catecholamines are required for androgen-induced ODC expression but not for hypertrophy of mouse kidney.
Topics: Animals; Arginine; Catecholamines; Eflornithine; Enzyme Induction; Female; Gene Expression Regulatio | 1997 |
Effects of polyamine synthesis inhibition on polyamines, growth and mechanical properties in hypertrophic rat urinary bladder.
Topics: Adenosylmethionine Decarboxylase; Amidines; Animals; Biogenic Polyamines; Calcium; Eflornithine; Enz | 1998 |
Hypertrophy and hyperfunction of the diabetic kidney.
Topics: Animals; Diabetic Nephropathies; Eflornithine; Enzyme Inhibitors; Glomerular Filtration Rate; Humans | 2001 |
Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes.
Topics: Animals; Carboxy-Lyases; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Eflornithine; Enzy | 2001 |
Role of polyamines and intracellular pH change in the hypertrophy of the denervated rat hemidiaphragm.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Denervation; Eflornithine; Hydrogen-Ion Concentration; Hypertr | 1988 |
Renal ornithine decarboxylase activity, polyamines, and compensatory renal hypertrophy in the rat.
Topics: Animals; Eflornithine; Hypertrophy; Kidney; Kinetics; Male; Nephrectomy; Ornithine Decarboxylase; Pu | 1988 |