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eflornithine and Hypertension, Pulmonary

eflornithine has been researched along with Hypertension, Pulmonary in 3 studies

Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.

Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.

Research Excerpts

ExcerptRelevanceReference
"Previously, we have shown that the protection provided by 2-difluoromethylornithine (DFMO) against the development of monocrotaline (MCT)-induced pulmonary hypertension (PH) is associated with inhibition of polyamine biosynthesis in the lungs of MCT-treated rats."7.68Inhibition of deoxyribonucleic acid synthesis by difluoromethylornithine. Role of polyamine metabolism in monocrotaline-induced pulmonary hypertension. ( Hacker, AD, 1992)
"Lung putrescine levels were increased from days 7 through 21, and both spermidine and spermine were first elevated at day 10 following MCT administration."5.27Polyamines and the development of monocrotaline-induced pulmonary hypertension. ( Altiere, RJ; Gillespie, MN; Hacker, AD; Olson, JW, 1984)
"Previously, we have shown that the protection provided by 2-difluoromethylornithine (DFMO) against the development of monocrotaline (MCT)-induced pulmonary hypertension (PH) is associated with inhibition of polyamine biosynthesis in the lungs of MCT-treated rats."3.68Inhibition of deoxyribonucleic acid synthesis by difluoromethylornithine. Role of polyamine metabolism in monocrotaline-induced pulmonary hypertension. ( Hacker, AD, 1992)
"Lung putrescine levels were increased from days 7 through 21, and both spermidine and spermine were first elevated at day 10 following MCT administration."1.27Polyamines and the development of monocrotaline-induced pulmonary hypertension. ( Altiere, RJ; Gillespie, MN; Hacker, AD; Olson, JW, 1984)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19902 (66.67)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Olson, JW2
Hacker, AD2
Altiere, RJ1
Gillespie, MN2
Orlinska, U1

Other Studies

3 other studies available for eflornithine and Hypertension, Pulmonary

ArticleYear
Polyamines and the development of monocrotaline-induced pulmonary hypertension.
    The American journal of physiology, 1984, Volume: 247, Issue:4 Pt 2

    Topics: Adenosylmethionine Decarboxylase; Animals; Blood Pressure; Eflornithine; Heart Ventricles; Hypertens

1984
Inhibition of deoxyribonucleic acid synthesis by difluoromethylornithine. Role of polyamine metabolism in monocrotaline-induced pulmonary hypertension.
    Biochemical pharmacology, 1992, Sep-01, Volume: 44, Issue:5

    Topics: Animals; Biogenic Polyamines; Blood Pressure; DNA; DNA Replication; Eflornithine; Hypertension, Pulm

1992
Polyamine synthesis blockade in monocrotaline-induced pneumotoxicity.
    Biochemical pharmacology, 1989, Sep-01, Volume: 38, Issue:17

    Topics: Animals; Biogenic Polyamines; Body Weight; Eflornithine; Heart; Hypertension, Pulmonary; Lung; Male;

1989