eflornithine has been researched along with Hypertension, Pulmonary in 3 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previously, we have shown that the protection provided by 2-difluoromethylornithine (DFMO) against the development of monocrotaline (MCT)-induced pulmonary hypertension (PH) is associated with inhibition of polyamine biosynthesis in the lungs of MCT-treated rats." | 7.68 | Inhibition of deoxyribonucleic acid synthesis by difluoromethylornithine. Role of polyamine metabolism in monocrotaline-induced pulmonary hypertension. ( Hacker, AD, 1992) |
| "Lung putrescine levels were increased from days 7 through 21, and both spermidine and spermine were first elevated at day 10 following MCT administration." | 5.27 | Polyamines and the development of monocrotaline-induced pulmonary hypertension. ( Altiere, RJ; Gillespie, MN; Hacker, AD; Olson, JW, 1984) |
| "Previously, we have shown that the protection provided by 2-difluoromethylornithine (DFMO) against the development of monocrotaline (MCT)-induced pulmonary hypertension (PH) is associated with inhibition of polyamine biosynthesis in the lungs of MCT-treated rats." | 3.68 | Inhibition of deoxyribonucleic acid synthesis by difluoromethylornithine. Role of polyamine metabolism in monocrotaline-induced pulmonary hypertension. ( Hacker, AD, 1992) |
| "Lung putrescine levels were increased from days 7 through 21, and both spermidine and spermine were first elevated at day 10 following MCT administration." | 1.27 | Polyamines and the development of monocrotaline-induced pulmonary hypertension. ( Altiere, RJ; Gillespie, MN; Hacker, AD; Olson, JW, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Olson, JW | 2 |
| Hacker, AD | 2 |
| Altiere, RJ | 1 |
| Gillespie, MN | 2 |
| Orlinska, U | 1 |
3 other studies available for eflornithine and Hypertension, Pulmonary
| Article | Year |
|---|---|
Polyamines and the development of monocrotaline-induced pulmonary hypertension.
Topics: Adenosylmethionine Decarboxylase; Animals; Blood Pressure; Eflornithine; Heart Ventricles; Hypertens | 1984 |
Inhibition of deoxyribonucleic acid synthesis by difluoromethylornithine. Role of polyamine metabolism in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Biogenic Polyamines; Blood Pressure; DNA; DNA Replication; Eflornithine; Hypertension, Pulm | 1992 |
Polyamine synthesis blockade in monocrotaline-induced pneumotoxicity.
Topics: Animals; Biogenic Polyamines; Body Weight; Eflornithine; Heart; Hypertension, Pulmonary; Lung; Male; | 1989 |