eflornithine has been researched along with Hyperplasia in 20 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although tamoxifen appears to markedly reduce breast cancer risk in women with a prior diagnosis of atypical hyperplasia or in situ carcinoma, it is not clear what other groups of women receive substantial benefit." | 8.81 | Beyond tamoxifen new endpoints for breast cancer chemoprevention, new drugs for breast cancer prevention. ( Fabian, CJ; Kimler, BF, 2001) |
| "Although tamoxifen appears to markedly reduce breast cancer risk in women with a prior diagnosis of atypical hyperplasia or in situ carcinoma, it is not clear what other groups of women receive substantial benefit." | 4.81 | Beyond tamoxifen new endpoints for breast cancer chemoprevention, new drugs for breast cancer prevention. ( Fabian, CJ; Kimler, BF, 2001) |
| " This study examined the effects of polyamine synthesis inhibition using eflornithine, a suicide inhibitor of ornithine decarboxylase on blood pressure, compensatory remodeling of the cardiovascular system, and cardiac and aortic polyamine contents using an aortic coarctation model in rats." | 3.69 | Multiple polyamine regulatory pathways control compensatory cardiovascular hypertrophy in coarctation hypertension. ( Arcot, SS; Aziz, SM; Guo, H; Lipke, DW; Newman, PS; Olson, JW; Soltis, EE; Tofiq, S, 1997) |
| "To determine the role of putrescine synthesis in adaptive hyperplasia of the ileum and colon, DL-alpha-difluoromethylornithine (DFMO), an enzyme-activated, irreversible inhibitor of ornithine decarboxylase (ODC), the enzyme controlling putrescine biosynthesis, was fed to rats after excision of the proximal half of the small bowel." | 3.67 | Inhibition of ileal and colonic ornithine decarboxylase activity by alpha-difluoromethylornithine in rats: transient atrophic changes and loss of postresectional adaptive growth. ( Abu-Khalaf, M; Diekema, KA; Kingsnorth, AN; LaMuraglia, GM; Malt, RA; McCann, PP; Ross, JS, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (25.00) | 18.7374 |
| 1990's | 13 (65.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Seidel, ER | 1 |
| Haddox, MK | 1 |
| Johnson, LR | 2 |
| Luk, GD | 1 |
| Baylin, SB | 1 |
| Luck, MS | 1 |
| Bass, P | 1 |
| Manteuffel-Cymborowska, M | 1 |
| Chmurzyńska, W | 1 |
| Grzelakowska-Sztabert, B | 1 |
| Younoszai, MK | 4 |
| Parekh, VV | 4 |
| Hoffman, JL | 4 |
| Tanaka, T | 1 |
| Kojima, T | 1 |
| Hara, A | 1 |
| Sawada, H | 1 |
| Mori, H | 1 |
| Stephen, TC | 1 |
| Ulshen, MH | 1 |
| Hoyt, EC | 1 |
| Fuller, CR | 1 |
| Ghatei, MA | 1 |
| Bloom, SR | 1 |
| Lund, PK | 1 |
| Lipke, DW | 1 |
| Newman, PS | 1 |
| Tofiq, S | 1 |
| Guo, H | 1 |
| Arcot, SS | 1 |
| Aziz, SM | 1 |
| Olson, JW | 1 |
| Soltis, EE | 1 |
| Mitsunaga, S | 1 |
| Clapper, M | 1 |
| Litwin, S | 1 |
| Watts, P | 1 |
| Bauer, B | 1 |
| Klein-Szanto, AJ | 1 |
| Kimler, BF | 2 |
| Fabian, CJ | 2 |
| Wallace, DD | 1 |
| Wang, JY | 1 |
| Tsai, YH | 1 |
| Castro, GA | 1 |
| Endean, ED | 1 |
| Kispert, JF | 1 |
| Martin, KW | 1 |
| O'Connor, W | 1 |
| Bamba, T | 1 |
| Vaja, S | 2 |
| Murphy, GM | 3 |
| Dowling, RH | 3 |
| Kingsnorth, AN | 1 |
| Abu-Khalaf, M | 1 |
| LaMuraglia, GM | 1 |
| McCann, PP | 1 |
| Diekema, KA | 1 |
| Ross, JS | 1 |
| Malt, RA | 1 |
| Hosomi, M | 2 |
| Lirussi, F | 2 |
| Stace, NH | 2 |
| Miazza, B | 1 |
| Levan, H | 1 |
1 review available for eflornithine and Hyperplasia
| Article | Year |
|---|---|
Beyond tamoxifen new endpoints for breast cancer chemoprevention, new drugs for breast cancer prevention.
Topics: Aneuploidy; Angiogenesis Inhibitors; Anticarcinogenic Agents; Apoptosis; Aromatase Inhibitors; Breas | 2001 |
19 other studies available for eflornithine and Hyperplasia
| Article | Year |
|---|---|
Polyamines in the response to intestinal obstruction.
Topics: Animals; Colon; Eflornithine; Gastric Mucosa; Hyperplasia; Ileum; Intestinal Obstruction; Male; Orni | 1984 |
Inhibition of intestinal epithelial DNA synthesis and adaptive hyperplasia after jejunectomy in the rat by suppression of polyamine biosynthesis.
Topics: Animals; DNA Replication; Eflornithine; Epithelium; Female; Hyperplasia; Intestinal Mucosa; Intestin | 1984 |
Inhibition of ornithine decarboxylase does not prevent intestinal smooth muscle hyperplasia in the rat.
Topics: Animals; Biogenic Polyamines; DNA; Eflornithine; Hyperplasia; Intestines; Male; Muscle, Smooth; Orni | 1994 |
Polyamines in testosterone-induced hypertrophic and antifolate-induced hyperplastic mouse kidney. Differential effect of alpha-difluoromethylornithine.
Topics: Animals; Eflornithine; Female; Folic Acid; Hyperplasia; Hypertrophy; Kidney; Kidney Diseases; Mice; | 1993 |
Polyamines and intestinal epithelial hyperplasia in streptozotocin-diabetic rats.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Eflornithine; Epithelium; Hyperplasia; Intest | 1993 |
Chemoprevention of oral carcinogenesis by DL-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor: dose-dependent reduction in 4-nitroquinoline 1-oxide-induced tongue neoplasms in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma; Dose-Response Relationship, Drug; Drug Screening Assay | 1993 |
Relation of ornithine decarboxylase and tyrosine kinase activity in the jejunal mucosa in vivo.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; DNA; Drinking; Eating; Eflornithine; Electrop | 1996 |
Increased ileal proglucagon expression after jejunectomy is not suppressed by inhibition of bowel growth.
Topics: Adaptation, Physiological; Animals; Blotting, Northern; Eflornithine; Enzyme Inhibitors; Glucagon; G | 1996 |
Multiple polyamine regulatory pathways control compensatory cardiovascular hypertrophy in coarctation hypertension.
Topics: Animals; Aorta, Abdominal; Aortic Coarctation; Blood Pressure; Blotting, Northern; Eflornithine; Enz | 1997 |
Effects of diabetes and difluoromethylornithine treatment on hyperplasia, activity of MAP-kinase, and activity and association with cyclin B of p34cdc2 kinase in rat jejunal mucosa.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; Cyclin B; Diabetes Melli | 1998 |
Chemopreventive effect of difluoromethylornithine (DFMO) on mouse skin squamous cell carcinomas induced by benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Eflornithine; Female; Hyperplasia; M | 1997 |
Role of tyrosine kinase, ODC, and p34cdc2 kinase and cyclin B-associated cdc2 in jejunal enterocyte proliferation, maturation, and exfoliation in diabetic and DFMO-treated rats.
Topics: Animals; Biomarkers; CDC2 Protein Kinase; Cell Division; Cyclin B; Cyclin-Dependent Kinase-Activatin | 1999 |
Breast cancer chemoprevention trials using the fine-needle aspiration model.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Biopsy, Needle; Breast; Breast Neoplasms; Clinical Protoco | 2000 |
Mucosal ornithine decarboxylase, polyamines, and hyperplasia in infected intestine.
Topics: Animals; Chromatography, High Pressure Liquid; DNA Replication; Duodenum; Eflornithine; Hyperplasia; | 1991 |
Intimal hyperplasia is reduced by ornithine decarboxylase inhibition.
Topics: Animals; Eflornithine; Endothelium, Vascular; Hyperplasia; Ornithine Decarboxylase Inhibitors; Polya | 1991 |
Role of polyamines in the early adaptive response to jejunectomy in the rat: effect of DFMO on the ileal villus:crypt axis.
Topics: Adaptation, Physiological; Alkaline Phosphatase; Amine Oxidase (Copper-Containing); Animals; Biogeni | 1990 |
Inhibition of ileal and colonic ornithine decarboxylase activity by alpha-difluoromethylornithine in rats: transient atrophic changes and loss of postresectional adaptive growth.
Topics: Adaptation, Physiological; Animals; Colon; DNA; Eflornithine; Hyperplasia; Ileum; Male; Ornithine; O | 1986 |
Mucosal polyamine profile in normal and adapting (hypo and hyperplastic) intestine: effects of DFMO treatment.
Topics: Adaptation, Physiological; Animals; Eflornithine; Hyperplasia; Intestinal Mucosa; Intestine, Small; | 1987 |
Hormones and polyamines in intestinal and pancreatic adaptation.
Topics: Adaptation, Physiological; Amine Oxidase (Copper-Containing); Animals; Biliary Tract; Cholecystokini | 1985 |