eflornithine has been researched along with Hormone-Dependent Neoplasms in 10 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although tamoxifen appears to markedly reduce breast cancer risk in women with a prior diagnosis of atypical hyperplasia or in situ carcinoma, it is not clear what other groups of women receive substantial benefit." | 8.81 | Beyond tamoxifen new endpoints for breast cancer chemoprevention, new drugs for breast cancer prevention. ( Fabian, CJ; Kimler, BF, 2001) |
| "Although tamoxifen appears to markedly reduce breast cancer risk in women with a prior diagnosis of atypical hyperplasia or in situ carcinoma, it is not clear what other groups of women receive substantial benefit." | 4.81 | Beyond tamoxifen new endpoints for breast cancer chemoprevention, new drugs for breast cancer prevention. ( Fabian, CJ; Kimler, BF, 2001) |
| "These experiments were designed to test polyamine (PA) involvement in the secretion and action of transforming growth factor alpha (TGF-alpha) in hormone responsive MCF-7 breast cancer cells in liquid culture." | 3.68 | Polyamine involvement in the secretion and action of TGF-alpha in hormone sensitive human breast cancer cells in culture. ( Demers, L; Kim, I; Lynch, J; Manni, A, 1991) |
| " ODC gene dosage was analyzed by Southern blot hybridization and was 4- to 12-fold higher in T-47D, MDA-MB-231, and BT-20 cell lines than in the MCF-7 cell line." | 1.28 | Variations in amplification and expression of the ornithine decarboxylase gene in human breast cancer cells. ( Jänne, OA; Kiang, DT; Thomas, T; Thomas, TJ, 1991) |
| "PA involvement in IGFBPs production by breast cancer cells is complex and may involve differential regulation of transcriptional and post-translational events." | 1.28 | Identification and regulation of insulin-like growth factor binding proteins produced by hormone-dependent and -independent human breast cancer cell lines. ( Hammond, JM; Kim, I; Lynch, J; Manni, A, 1991) |
| "Putrescine is a potential scanning agent for metastases of prostatic carcinoma." | 1.27 | alpha-Difluoromethylornithine enhancement of 14C-putrescine uptake by an androgen-dependent prostatic tumor. ( Heston, WD; Kadmon, D, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hu, X | 1 |
| Washington, S | 1 |
| Verderame, MF | 1 |
| Manni, A | 5 |
| Thomas, T | 2 |
| Shah, N | 1 |
| Klinge, CM | 1 |
| Faaland, CA | 1 |
| Adihkarakunnathu, S | 1 |
| Gallo, MA | 1 |
| Thomas, TJ | 2 |
| Fabian, CJ | 1 |
| Kimler, BF | 1 |
| Badger, B | 1 |
| Martel, J | 1 |
| Demers, L | 3 |
| Kiang, DT | 1 |
| Jänne, OA | 1 |
| Kim, I | 2 |
| Lynch, J | 2 |
| Hammond, JM | 1 |
| Glikman, P | 1 |
| Bartholomew, M | 1 |
| Heston, WD | 1 |
| Kadmon, D | 1 |
| Kendra, KL | 1 |
| Katzenellenbogen, BS | 1 |
1 review available for eflornithine and Hormone-Dependent Neoplasms
| Article | Year |
|---|---|
Beyond tamoxifen new endpoints for breast cancer chemoprevention, new drugs for breast cancer prevention.
Topics: Aneuploidy; Angiogenesis Inhibitors; Anticarcinogenic Agents; Apoptosis; Aromatase Inhibitors; Breas | 2001 |
9 other studies available for eflornithine and Hormone-Dependent Neoplasms
| Article | Year |
|---|---|
Interaction between Polyamines and the Mitogen-Activated Protein Kinase Pathway in the Regulation of Cell Cycle Variables in Breast Cancer Cells.
Topics: Breast Neoplasms; Butadienes; Calcium-Binding Proteins; Cell Cycle; Cell Growth Processes; Cell Line | 2005 |
Polyamine biosynthesis inhibitors alter protein-protein interactions involving estrogen receptor in MCF-7 breast cancer cells.
Topics: Amidines; Animals; Biogenic Polyamines; Breast Neoplasms; Cell Division; Eflornithine; Estradiol; Fe | 1999 |
Role of polyamines in the growth of hormone-responsive and -resistant human breast cancer cells in nude mice.
Topics: Animals; Breast Neoplasms; Cell Division; Drug Resistance; Drug Screening Assays, Antitumor; Eflorni | 1992 |
Variations in amplification and expression of the ornithine decarboxylase gene in human breast cancer cells.
Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma; Carcinoma, Intraductal, Noninfiltrating; DNA, Neoplasm; | 1991 |
Identification and regulation of insulin-like growth factor binding proteins produced by hormone-dependent and -independent human breast cancer cell lines.
Topics: Breast Neoplasms; Carcinoma; Carrier Proteins; Cell Division; Eflornithine; Estradiol; Humans; Insul | 1991 |
Polyamine involvement in the secretion and action of TGF-alpha in hormone sensitive human breast cancer cells in culture.
Topics: Breast Neoplasms; Cell Division; Eflornithine; Estrogens; Humans; In Vitro Techniques; Neoplasms, Ho | 1991 |
Polyamine involvement in the growth of hormone-responsive and -resistant human breast cancer cells in culture.
Topics: Biogenic Polyamines; Breast Neoplasms; Cell Count; Dose-Response Relationship, Drug; Eflornithine; F | 1989 |
alpha-Difluoromethylornithine enhancement of 14C-putrescine uptake by an androgen-dependent prostatic tumor.
Topics: Adenocarcinoma; Androgens; Animals; Carbon Radioisotopes; Dexamethasone; Dihydrotestosterone; Eflorn | 1986 |
An evaluation of the involvement of polyamines in modulating MCF-7 human breast cancer cell proliferation and progesterone receptor levels by estrogen and antiestrogen.
Topics: Breast Neoplasms; Cell Division; Cell Line; Eflornithine; Estradiol; Humans; Neoplasms, Hormone-Depe | 1987 |