eflornithine has been researched along with Hirsutism in 37 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Hirsutism: A condition observed in WOMEN and CHILDREN when there is excess coarse body hair of an adult male distribution pattern, such as facial and chest areas. It is the result of elevated ANDROGENS from the OVARIES, the ADRENAL GLANDS, or exogenous sources. The concept does not include HYPERTRICHOSIS, which is an androgen-independent excessive hair growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the efficacy of combination of Intense Pulse Light and topical eflornithine therapy versus Intense Pulse Light therapy alone in the treatment of idiopathic facial hirsutism." | 9.30 | Combination of Intense Pulse Light and Topical Eflornithine Therapy versus Intense Pulse Light Therapy alone in the Treatment of Idiopathic Facial Hirsutism: A Randomized Controlled Trial. ( Noor, SM; Paracha, MM; Zahoor, H, 2019) |
| "no eflornithine treatment (control) after 5-6 IPL-treatments in 22 women with facial hirsutism." | 6.82 | Adjuvant eflornithine to maintain IPL-induced hair reduction in women with facial hirsutism: a randomized controlled trial. ( Haak, CS; Haedersdal, M; Philipsen, PA; Taudorf, EH; Vissing, AC, 2016) |
| "This was a randomized, double-blind, placebo-controlled, right-left comparison study of eflornithine cream combined with laser treatment versus laser alone for treating unwanted hair on the upper lip in women." | 6.73 | A randomized bilateral vehicle-controlled study of eflornithine cream combined with laser treatment versus laser treatment alone for facial hirsutism in women. ( Hamzavi, I; Lui, H; Shapiro, J; Tan, E, 2007) |
| "Eflornithine is an effective treatment for unwanted facial hair in women, as reported by the patients." | 6.73 | The effect of eflornithine 13.9% cream on the bother and discomfort due to hirsutism. ( Caro, G; Caro, JJ; Garfield, F; Huber, F; Jackson, J; Lin, CS; Schrode, K; Shander, D; Zhou, W, 2007) |
| " Additionally, novel cosmetic techniques like electrolysis, laser and use of topically applied eflornithine to tackle the most distressing feature of facial hirsutism associated with PCOS, non-pharmacological therapy like acupuncture and the role of herbal medicine in PCOS management have also been discussed." | 5.22 | Polycystic ovarian syndrome-current pharmacotherapy and clinical implications. ( Ali, T; Amin, F; Ara, R; Bader, GN; Kareem, O; Malik, A; Mir, SA; Rashid, R, 2022) |
| " Moreover, assessment of biochemical hyperandrogenism is necessary, particularly in patients with unclear or absent hirsutism, and will include assessing total and free testosterone (T), and possibly dehydroepiandrosterone sulfate (DHEAS) and androstenedione, although these latter contribute limitedly to the diagnosis." | 4.93 | Androgen excess: Investigations and management. ( Azziz, R; Gavrilova-Jordan, L; Lizneva, D; Walker, W, 2016) |
| " Topical eflornithine can be used as monotherapy for mild hirsutism and as an adjunct therapy with lasers or pharmacotherapy in more severe cases." | 4.90 | Hirsutism: an evidence-based treatment update. ( Somani, N; Turvy, D, 2014) |
| "α-Difluoromethylornithine or Eflornithine is an FDA-approved drug used for the treatment of Sleeping Sickness (as vials dosage form) and also used for diminishing the unwanted excess facial hair in the hirsutism (as creams dosage form)." | 4.02 | Micellar sensitized Resonance Rayleigh Scattering and spectrofluorometric methods based on isoindole formation for determination of Eflornithine in cream and biological samples. ( Abdel-Lateef, MA; Almahri, A, 2021) |
| "This was a randomized, double-blind, placebo-controlled, right-left comparison study of eflornithine cream combined with laser treatment versus laser alone for treating unwanted hair on the upper lip in women." | 2.73 | A randomized bilateral vehicle-controlled study of eflornithine cream combined with laser treatment versus laser treatment alone for facial hirsutism in women. ( Hamzavi, I; Lui, H; Shapiro, J; Tan, E, 2007) |
| "Eflornithine is safely used in conjunction with laser hair removal treatments and promotes more rapid hair removal when combined with laser treatment." | 2.72 | Eflornithine cream combined with laser therapy in the management of unwanted facial hair growth in women: a randomized trial. ( Beger, B; Littler, C; Piacquadio, DJ; Smith, SR, 2006) |
| "Eflornithine was eliminated from plasma with a mean terminal half-life of 11 hours (first application) and 8 hours (final application)." | 2.70 | Percutaneous absorption and pharmacokinetics of eflornithine HCl 13.9% cream in women with unwanted facial hair. ( Behr, D; Malhotra, B; Noveck, R; Palmisano, M, 2001) |
| "Hirsutism is the excessive growth of terminal hair in a typical male pattern in a female." | 2.61 | Hirsutism in Women. ( Bain, J; Matheson, E, 2019) |
| "Putrescine plays a very important role in the regulation of division, differentiation and maturation of cells as well as apoptosis." | 2.50 | [The importance of putrescine in the human body]. ( Lachowski, M; Zdrojewicz, Z, 2014) |
| "Hirsutism is an excessive body and facial hair growth in women in locations where is normally minimal or absent following a hair-male pattern." | 2.46 | Comprehensive clinical management of hirsutism. ( Cancelo, MJ; Castelo-Branco, C, 2010) |
| "Hirsutism is defined as excess hair growth in androgen-dependent areas of the body in women." | 2.46 | Hirsutism: Diagnosis and management. ( Brodell, LA; Mercurio, MG, 2010) |
| "Once pseudofolliculitis has become established, treatment consists of avoiding shaving and the use of medical treatment similar to that used in acne." | 2.46 | [Pseudofolliculitis barbae]. ( Casals, M; Fernández-Chico, N; Ribera, M, 2010) |
| "Hirsutism is defined as the excessive growth of terminal hair on the face and body of a female in a typical male pattern distribution." | 2.44 | Hirsutism. ( Mofid, A; Seyyed Alinaghi, SA; Yazdani, T; Zandieh, S, 2008) |
| "Hirsutism and acne are common and highly distressing complaints in women with polycystic ovary syndrome (PCOS)." | 2.43 | Treatment of hirsutism and acne in hyperandrogenism. ( Moghetti, P; Toscano, V, 2006) |
| "Hirsutism is the presence of terminal (coarse) hairs in females in a male-like pattern, affecting between 5% and 15% of women, depending on definition." | 2.42 | The evaluation and management of hirsutism. ( Azziz, R, 2003) |
| "Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase which is thought to slow hair growth by inhibiting this enzyme in hair follicles." | 2.41 | Topical eflornithine. ( Balfour, JA; McClellan, K, 2001) |
| "A new topical treatment of hypertrichosis is eflornithine cream." | 2.41 | [Current treatment of hypertrichosis]. ( Kunte, C; Wolff, H, 2001) |
| "Eflornithine cream is indicated for the treatment of facial hirsutism." | 1.43 | A method to improve the efficacy of topical eflornithine hydrochloride cream. ( Cui, Z; Kumar, A; Naguib, YW; Shi, YC, 2016) |
| "Hirsutism is a common disorder affecting between 5 and 15% of the population." | 1.36 | Best practice options for hair removal in patients with unwanted facial hair using combination therapy with laser: guidelines drawn up by an expert working group. ( Adatto, M; Campo-Voegeli, A; Dahan, S; Dierickx, C; Lanigan, S; Lapidoth, M; Marini, L; Paasch, U, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 21 (56.76) | 29.6817 |
| 2010's | 13 (35.14) | 24.3611 |
| 2020's | 3 (8.11) | 2.80 |
| Authors | Studies |
|---|---|
| Rashid, R | 1 |
| Mir, SA | 1 |
| Kareem, O | 1 |
| Ali, T | 1 |
| Ara, R | 1 |
| Malik, A | 1 |
| Amin, F | 1 |
| Bader, GN | 1 |
| Almahri, A | 2 |
| Abdel-Lateef, MA | 1 |
| Zahoor, H | 1 |
| Noor, SM | 1 |
| Paracha, MM | 1 |
| Matheson, E | 1 |
| Bain, J | 1 |
| Zdrojewicz, Z | 1 |
| Lachowski, M | 1 |
| Somani, N | 1 |
| Turvy, D | 1 |
| Kumar, A | 1 |
| Naguib, YW | 1 |
| Shi, YC | 1 |
| Cui, Z | 1 |
| van Zuuren, EJ | 1 |
| Fedorowicz, Z | 1 |
| Carter, B | 1 |
| Pandis, N | 1 |
| Vissing, AC | 1 |
| Taudorf, EH | 1 |
| Haak, CS | 1 |
| Philipsen, PA | 1 |
| Haedersdal, M | 1 |
| Lizneva, D | 1 |
| Gavrilova-Jordan, L | 1 |
| Walker, W | 1 |
| Azziz, R | 2 |
| Mason, H | 1 |
| Colao, A | 1 |
| Blume-Peytavi, U | 1 |
| Rice, S | 1 |
| Qureshi, A | 1 |
| Pellatt, L | 1 |
| Orio, F | 1 |
| Atkin, SL | 1 |
| Namazi, MR | 1 |
| Feily, A | 1 |
| Kumar, R | 1 |
| St John, J | 1 |
| Devendra, D | 1 |
| Castelo-Branco, C | 1 |
| Cancelo, MJ | 1 |
| Brodell, LA | 1 |
| Mercurio, MG | 2 |
| Lapidoth, M | 1 |
| Dierickx, C | 1 |
| Lanigan, S | 2 |
| Paasch, U | 1 |
| Campo-Voegeli, A | 1 |
| Dahan, S | 1 |
| Marini, L | 1 |
| Adatto, M | 1 |
| Ribera, M | 1 |
| Fernández-Chico, N | 1 |
| Casals, M | 1 |
| Franks, S | 1 |
| Dawber, RP | 1 |
| Moghetti, P | 1 |
| Toscano, V | 1 |
| Ganger, LK | 1 |
| Hamzavi, IH | 1 |
| Randall, VA | 1 |
| Hamzavi, I | 2 |
| Chamberlain James, L | 1 |
| Smith, SR | 1 |
| Piacquadio, DJ | 1 |
| Beger, B | 1 |
| Littler, C | 1 |
| Wolf, JE | 1 |
| Shander, D | 2 |
| Huber, F | 2 |
| Jackson, J | 2 |
| Lin, CS | 2 |
| Mathes, BM | 1 |
| Schrode, K | 2 |
| Tan, E | 1 |
| Shapiro, J | 1 |
| Lui, H | 1 |
| Caro, JJ | 1 |
| Caro, G | 1 |
| Garfield, F | 1 |
| Zhou, W | 1 |
| Mofid, A | 1 |
| Seyyed Alinaghi, SA | 1 |
| Zandieh, S | 1 |
| Yazdani, T | 1 |
| Hennemann, A | 1 |
| Malhotra, B | 1 |
| Noveck, R | 1 |
| Behr, D | 1 |
| Palmisano, M | 1 |
| Coyne, PE | 1 |
| Balfour, JA | 1 |
| McClellan, K | 1 |
| Kunte, C | 1 |
| Wolff, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Gender Affirmative Treatment of Hypertrichosis With Intense Pulsed Light - Effect on Hair Reduction and Quality of Life[NCT05775328] | 39 participants (Anticipated) | Observational | 2023-12-01 | Not yet recruiting | |||
| TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563] | Phase 2 | 70 participants (Anticipated) | Interventional | 2023-03-14 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
19 reviews available for eflornithine and Hirsutism
| Article | Year |
|---|---|
Polycystic ovarian syndrome-current pharmacotherapy and clinical implications.
Topics: Acupuncture; Anovulation; Eflornithine; Female; Herbal Medicine; Hirsutism; Humans; Hydroxymethylglu | 2022 |
Hirsutism in Women.
Topics: Adrenal Hyperplasia, Congenital; Androgen Antagonists; Antineoplastic Agents, Hormonal; Contraceptiv | 2019 |
[The importance of putrescine in the human body].
Topics: Apoptosis; Cell Differentiation; Cell Division; Cell Membrane; Eflornithine; Hirsutism; Homeostasis; | 2014 |
Hirsutism: an evidence-based treatment update.
Topics: Androgen Antagonists; Contraceptives, Oral, Combined; Eflornithine; Evidence-Based Medicine; Female; | 2014 |
Interventions for hirsutism (excluding laser and photoepilation therapy alone).
Topics: 5-alpha Reductase Inhibitors; Adult; Androgen Antagonists; Body Mass Index; Contraceptive Agents, Fe | 2015 |
Androgen excess: Investigations and management.
Topics: 5-alpha Reductase Inhibitors; Acne Vulgaris; Alopecia; Androgen Antagonists; Androstenedione; Contra | 2016 |
Polycystic ovary syndrome (PCOS) trilogy: a translational and clinical review.
Topics: Acne Vulgaris; Alopecia; Anovulation; Cardiovascular Diseases; Eflornithine; Female; Hirsutism; Huma | 2008 |
Comprehensive clinical management of hirsutism.
Topics: Contraceptives, Oral, Combined; Eflornithine; Female; Hair Removal; Hirsutism; Humans; Weight Loss | 2010 |
Hirsutism: Diagnosis and management.
Topics: 5-alpha Reductase Inhibitors; Adrenal Hyperplasia, Congenital; Causality; Contraceptives, Oral; Diag | 2010 |
[Pseudofolliculitis barbae].
Topics: Benzoyl Peroxide; Black People; Cicatrix; Combined Modality Therapy; Dermatologic Agents; Disease Su | 2010 |
The evaluation and management of hirsutism.
Topics: Androgen Antagonists; Contraceptives, Oral; Diagnosis, Differential; Eflornithine; Female; Hair Remo | 2003 |
Guidance for the management of hirsutism.
Topics: Administration, Topical; Cosmetic Techniques; Eflornithine; Enzyme Inhibitors; Female; Hair Removal; | 2005 |
Treatment of hirsutism and acne in hyperandrogenism.
Topics: 5-alpha Reductase Inhibitors; Acne Vulgaris; Androgen Antagonists; Anti-Bacterial Agents; Combined M | 2006 |
New dimensions in Hirsutism.
Topics: Androgens; Cholestenone 5 alpha-Reductase; Eflornithine; Enzyme Inhibitors; Female; Hirsutism; Human | 2006 |
Does eflornithine help women face hirsutism?
Topics: Adult; Drug Costs; Eflornithine; Enzyme Inhibitors; Female; Hirsutism; Humans; Middle Aged; Randomiz | 2007 |
Hirsutism.
Topics: Diagnosis, Differential; Eflornithine; Enzyme Inhibitors; Female; Hair Removal; Hirsutism; Humans; H | 2008 |
Hirsutism: diagnosis and management.
Topics: Adrenal Hyperplasia, Congenital; Androgens; Contraceptives, Oral; Eflornithine; Enzyme Inhibitors; F | 2001 |
Topical eflornithine.
Topics: Administration, Cutaneous; Chemistry, Pharmaceutical; Eflornithine; Face; Female; Hair Follicle; Hir | 2001 |
[Current treatment of hypertrichosis].
Topics: Eflornithine; Electrolysis; Enzyme Inhibitors; Female; Hair Removal; Hirsutism; Humans; Hypertrichos | 2001 |
7 trials available for eflornithine and Hirsutism
| Article | Year |
|---|---|
Combination of Intense Pulse Light and Topical Eflornithine Therapy versus Intense Pulse Light Therapy alone in the Treatment of Idiopathic Facial Hirsutism: A Randomized Controlled Trial.
Topics: Administration, Topical; Adult; Combined Modality Therapy; Eflornithine; Face; Female; Hirsutism; Hu | 2019 |
Adjuvant eflornithine to maintain IPL-induced hair reduction in women with facial hirsutism: a randomized controlled trial.
Topics: Administration, Topical; Adolescent; Adult; Dose-Response Relationship, Drug; Eflornithine; Face; Fe | 2016 |
Eflornithine cream combined with laser therapy in the management of unwanted facial hair growth in women: a randomized trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Double-Blind Method; Eflornithine; Face; Fe | 2006 |
Randomized, double-blind clinical evaluation of the efficacy and safety of topical eflornithine HCl 13.9% cream in the treatment of women with facial hair.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Double-Blind Method; Eflornithi | 2007 |
A randomized bilateral vehicle-controlled study of eflornithine cream combined with laser treatment versus laser treatment alone for facial hirsutism in women.
Topics: Adult; Aged; Combined Modality Therapy; Double-Blind Method; Eflornithine; Female; Hair Removal; Hir | 2007 |
The effect of eflornithine 13.9% cream on the bother and discomfort due to hirsutism.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Double-Blind Method; Eflornithi | 2007 |
Percutaneous absorption and pharmacokinetics of eflornithine HCl 13.9% cream in women with unwanted facial hair.
Topics: Administration, Topical; Adolescent; Adult; Area Under Curve; Eflornithine; Enzyme Inhibitors; Feces | 2001 |
11 other studies available for eflornithine and Hirsutism
| Article | Year |
|---|---|
Utility of 4-chloro-7-nitrobenzofurazan for spectrofluorimetric and spectrophotometric determinations of the anti-hirsutism agent (α-difluoromethylornithine) in pharmaceutical cream samples.
Topics: 4-Chloro-7-nitrobenzofurazan; Eflornithine; Hirsutism; Humans; Hydrogen-Ion Concentration; Pharmaceu | 2021 |
Micellar sensitized Resonance Rayleigh Scattering and spectrofluorometric methods based on isoindole formation for determination of Eflornithine in cream and biological samples.
Topics: Eflornithine; Hirsutism; Humans; Isoindoles; Micelles; Spectrometry, Fluorescence | 2021 |
A method to improve the efficacy of topical eflornithine hydrochloride cream.
Topics: Administration, Cutaneous; Administration, Topical; Animals; Eflornithine; Face; Female; Hair Follic | 2016 |
Green tea extract: a novel addition to the antihirsutism armamentarium?
Topics: Camellia sinensis; Catechin; Eflornithine; Flavonoids; Hirsutism; Humans; Phytotherapy; Plant Extrac | 2009 |
Hirsutism.
Topics: Contraceptives, Oral; Eflornithine; Enzyme Inhibitors; Female; Hirsutism; Humans; Medical History Ta | 2009 |
Best practice options for hair removal in patients with unwanted facial hair using combination therapy with laser: guidelines drawn up by an expert working group.
Topics: Combined Modality Therapy; Eflornithine; Face; Female; Hair Removal; Hirsutism; Humans; Laser Therap | 2010 |
The investigation and management of hirsutism.
Topics: Adrenal Glands; Androgen Antagonists; Androgens; Contraceptives, Oral, Hormonal; Eflornithine; Endoc | 2012 |
Excess salt and pepper hair treated with a combination of laser hair removal and topical eflornithine HCl.
Topics: Administration, Topical; Eflornithine; Enzyme Inhibitors; Female; Hirsutism; Humans; Low-Level Light | 2006 |
[Eflornithine for hair removal. Topical application for hirsutism].
Topics: Administration, Topical; Eflornithine; Female; Hair Removal; Hirsutism; Humans; Randomized Controlle | 2001 |
The eflornithine story.
Topics: Administration, Topical; Developing Countries; Drug Industry; Eflornithine; Enzyme Inhibitors; Hirsu | 2001 |
Eflornithine.
Topics: Depression, Chemical; Drug Costs; Drug Interactions; Eflornithine; Hair; Hirsutism; Humans | 2001 |