eflornithine has been researched along with Hepatic Encephalopathy in 2 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| " One group, termed stuporous (AS), received only enough ammonium acetate to interfere with grooming and exploratory activity; this dosage was insufficient to completely block the righting response, which was absent in the AC group." | 5.27 | Disruption of the blood-brain barrier in hyperammonemic coma and the pharmacologic effects of dexamethasone and difluoromethyl ornithine. ( Chandler, MD; McCandless, DW; Sears, ES, 1985) |
| " One group, termed stuporous (AS), received only enough ammonium acetate to interfere with grooming and exploratory activity; this dosage was insufficient to completely block the righting response, which was absent in the AC group." | 1.27 | Disruption of the blood-brain barrier in hyperammonemic coma and the pharmacologic effects of dexamethasone and difluoromethyl ornithine. ( Chandler, MD; McCandless, DW; Sears, ES, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yurdaydin, C | 1 |
| Swain, MG | 1 |
| Mininberg, ED | 1 |
| Vergalla, J | 1 |
| Kleiner, D | 1 |
| Paul, SM | 1 |
| Jones, EA | 1 |
| Sears, ES | 1 |
| McCandless, DW | 1 |
| Chandler, MD | 1 |
2 other studies available for eflornithine and Hepatic Encephalopathy
| Article | Year |
|---|---|
Effect of inhibition of ornithine decarboxylase activity in a model of acute hepatocellular necrosis.
Topics: Animals; Cytochrome P-450 Enzyme System; Disease Models, Animal; Eflornithine; Enzyme Inhibitors; He | 1998 |
Disruption of the blood-brain barrier in hyperammonemic coma and the pharmacologic effects of dexamethasone and difluoromethyl ornithine.
Topics: Acetates; Ammonia; Animals; Blood-Brain Barrier; Coma; Dexamethasone; Eflornithine; Exploratory Beha | 1985 |