eflornithine has been researched along with Head and Neck Neoplasms in 4 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three human squamous cell carcinoma (SCC) cell lines, derived from primary head and neck cancers, have been characterized in vitro via flow cytometric analysis of proliferation kinetics, and in vivo via tumor xenograft growth evaluation in athymic mice." | 1.29 | Modulation of proliferation kinetics in human squamous cell carcinomas of the head and neck. ( Contreras, L; Harari, PM; Kinsella, TJ; Pickart, MA; Ritter, MA, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Warrell, RP | 1 |
| Burchenal, JH | 1 |
| Petereit, DG | 1 |
| Harari, PM | 3 |
| Contreras, L | 2 |
| Pickart, MA | 3 |
| Verma, AK | 1 |
| Gerner, EW | 1 |
| Kinsella, TJ | 2 |
| Ritter, MA | 1 |
| Bock, JM | 1 |
| Pink, JJ | 1 |
1 review available for eflornithine and Head and Neck Neoplasms
| Article | Year |
|---|---|
Methylglyoxal-bis(guanylhydrazone) (Methyl-GAG): current status and future prospects.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemical Phenomena; Chemistry; Clinical Tri | 1983 |
1 trial available for eflornithine and Head and Neck Neoplasms
| Article | Year |
|---|---|
Methylglyoxal-bis(guanylhydrazone) (Methyl-GAG): current status and future prospects.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemical Phenomena; Chemistry; Clinical Tri | 1983 |
3 other studies available for eflornithine and Head and Neck Neoplasms
| Article | Year |
|---|---|
Combining polyamine depletion with radiation therapy for rapidly dividing head and neck tumors: strategies for improved locoregional control.
Topics: Animals; Carcinoma, Squamous Cell; Cell Survival; Combined Modality Therapy; Eflornithine; Female; F | 1994 |
Modulation of proliferation kinetics in human squamous cell carcinomas of the head and neck.
Topics: Animals; Carcinoma, Squamous Cell; Cell Cycle; Cell Division; Eflornithine; Flow Cytometry; Head and | 1993 |
Modulation of tumor cell proliferation and apoptosis by polyamine depletion in cells of head and neck squamous cell carcinomas.
Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Division; Cell Survival; Dose-Response Relationship, Drug; | 1999 |