eflornithine has been researched along with Glioma in 23 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study compared the antitumor activity of oral eflornithine with that of oral eflornithine combined with intravenous mitoguazone in the treatment of patients with recurrent or progressive glioblastoma multiforme as well as nonglioblastoma anaplastic gliomas." | 9.07 | Treatment of recurrent gliomas with eflornithine. ( Gleason, MJ; Ictech, S; Levin, VA; Malec, M; Prados, MD; Yung, WK, 1992) |
| "In the current study, we sought to determine whether the addition of DFMO (alpha-difluoromethyl ornithine; eflornithine), an inhibitor of ornithine decarboxylase, to a nitrosourea-based therapy procarbazine, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, vincristine (PCV) would be more effective as a postirradiation adjuvant therapy for anaplastic gliomas (AG) than PCV alone." | 5.10 | Phase III randomized study of postradiotherapy chemotherapy with combination alpha-difluoromethylornithine-PCV versus PCV for anaplastic gliomas. ( Bruner, JM; Choucair, A; Flynn, PJ; Gleason, MJ; Hess, KR; Ictech, S; Jaeckle, KA; Kim, HW; Kyritsis, AP; Levin, VA; Prados, MD; Yung, WK, 2003) |
| "This study compared the antitumor activity of oral eflornithine with that of oral eflornithine combined with intravenous mitoguazone in the treatment of patients with recurrent or progressive glioblastoma multiforme as well as nonglioblastoma anaplastic gliomas." | 5.07 | Treatment of recurrent gliomas with eflornithine. ( Gleason, MJ; Ictech, S; Levin, VA; Malec, M; Prados, MD; Yung, WK, 1992) |
| "889 with respect to OS, while BEV in combination with TMZ - with a probability of 0." | 2.53 | A network meta-analysis: the overall and progression-free survival of glioma patients treated by different chemotherapeutic interventions combined with radiation therapy (RT). ( Ding, L; Gao, L; Lv, P; Qi, L; Wang, S; Wang, W; Xu, Y; Zhao, D; Zhong, Y, 2016) |
| " We will use DFMO with or without AMXT-1501 to identify candidate pharmacodynamic biomarkers of polyamine depletion in patients with high-grade gliomas in situ ." | 1.91 | Glioma Metabolic Feedback In Situ: A First-In-Human Pharmacodynamic Trial of Difluoromethylornithine + AMXT-1501 Through High-Molecular Weight Microdialysis. ( Burns, TC; Hoplin, MD; Kizilbash, SH; Miska, J; Neth, BJ; Riviere-Cazaux, C; Wessel, B, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (21.74) | 18.7374 |
| 1990's | 9 (39.13) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 3 (13.04) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Riviere-Cazaux, C | 1 |
| Neth, BJ | 1 |
| Hoplin, MD | 1 |
| Wessel, B | 1 |
| Miska, J | 1 |
| Kizilbash, SH | 1 |
| Burns, TC | 1 |
| Levin, VA | 5 |
| Ictech, SE | 1 |
| Hess, KR | 3 |
| Alexiou, GA | 1 |
| Tsamis, KI | 1 |
| Vartholomatos, E | 1 |
| Peponi, E | 1 |
| Tzima, E | 1 |
| Tasiou, I | 1 |
| Lykoudis, E | 1 |
| Tsekeris, P | 1 |
| Kyritsis, AP | 3 |
| Qi, L | 1 |
| Ding, L | 1 |
| Wang, S | 2 |
| Zhong, Y | 1 |
| Zhao, D | 1 |
| Gao, L | 1 |
| Wang, W | 1 |
| Lv, P | 1 |
| Xu, Y | 1 |
| Pasanen, T | 1 |
| Karppinen, A | 1 |
| Alhonen, L | 2 |
| Jänne, J | 2 |
| Wahlfors, J | 2 |
| Choucair, A | 1 |
| Flynn, PJ | 1 |
| Jaeckle, KA | 2 |
| Yung, WK | 4 |
| Prados, MD | 3 |
| Bruner, JM | 1 |
| Ictech, S | 2 |
| Gleason, MJ | 2 |
| Kim, HW | 1 |
| Wahlfors, T | 1 |
| Hakkarainen, T | 1 |
| Jochec, JL | 1 |
| Shantz, LM | 1 |
| Aldape, KD | 1 |
| Chapman, SK | 1 |
| Hung, DT | 1 |
| Deen, DF | 2 |
| Seidenfeld, J | 1 |
| Marton, LJ | 1 |
| Kurihara, H | 2 |
| Matsuzaki, S | 2 |
| Tamura, M | 2 |
| Sugimoto, H | 1 |
| Tsukahara, T | 2 |
| Yamazaki, H | 2 |
| Redgate, ES | 3 |
| Grudziak, A | 1 |
| Floyd, KL | 1 |
| Deutsch, M | 2 |
| Boggs, SS | 3 |
| Grudziak, AG | 1 |
| Terzis, AJ | 1 |
| Pedersen, PH | 1 |
| Feuerstein, BG | 1 |
| Arnold, H | 1 |
| Bjerkvig, R | 1 |
| Buckner, JC | 1 |
| Burch, PA | 1 |
| Cascino, TL | 1 |
| O'Fallon, JR | 1 |
| Scheithauer, BW | 1 |
| Wong, ET | 1 |
| Alexander, D | 1 |
| Magra, TR | 1 |
| Henretty, JS | 1 |
| Patrene, KD | 1 |
| Malec, M | 1 |
| Melino, G | 1 |
| Stephanou, A | 1 |
| Annicchiarico-Petruzzelli, M | 1 |
| Finazzi-Agró, A | 1 |
| Knight, RA | 1 |
| Lightman, SL | 1 |
| Steck, PA | 1 |
| Kelleher, PJ | 1 |
| Moser, RP | 1 |
| Rosenblum, MG | 1 |
| Endo, Y | 1 |
| Matsushima, K | 1 |
| Onozaki, K | 1 |
| Oppenheim, JJ | 1 |
| Cohen, AR | 1 |
| Pietronigro, DD | 1 |
| Cravioto, H | 1 |
| Flamm, ES | 1 |
2 reviews available for eflornithine and Glioma
| Article | Year |
|---|---|
Clinical importance of eflornithine (α-difluoromethylornithine) for the treatment of malignant gliomas.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Clinical Trials as Topic; Eflornithine; Glioma; Hum | 2018 |
A network meta-analysis: the overall and progression-free survival of glioma patients treated by different chemotherapeutic interventions combined with radiation therapy (RT).
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bayes Theorem; Bevacizumab; Brain Neoplasm | 2016 |
4 trials available for eflornithine and Glioma
| Article | Year |
|---|---|
Phase III randomized study of postradiotherapy chemotherapy with combination alpha-difluoromethylornithine-PCV versus PCV for anaplastic gliomas.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasm | 2003 |
Phase II trial of recombinant interferon-alpha-2a and eflornithine in patients with recurrent glioma.
Topics: Adult; Aged; Disease Progression; Drug Therapy, Combination; Eflornithine; Female; Glioma; Humans; I | 1998 |
Response and progression in recurrent malignant glioma.
Topics: Actuarial Analysis; Adolescent; Adult; Aged; Aged, 80 and over; Alitretinoin; Antineoplastic Combine | 1999 |
Treatment of recurrent gliomas with eflornithine.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Child; Child, Preschool; Eflornithine; Female; Glioblastom | 1992 |
17 other studies available for eflornithine and Glioma
| Article | Year |
|---|---|
Glioma Metabolic Feedback In Situ: A First-In-Human Pharmacodynamic Trial of Difluoromethylornithine + AMXT-1501 Through High-Molecular Weight Microdialysis.
Topics: Biomarkers; Eflornithine; Feedback; Glioma; Humans; Microdialysis; Molecular Weight; Polyamines | 2023 |
Combination treatment of TRAIL, DFMO and radiation for malignant glioma cells.
Topics: Apoptosis; Blotting, Western; Brain Neoplasms; Cell Adhesion; Cell Movement; Cell Proliferation; Com | 2015 |
Polyamine biosynthesis inhibition enhances HSV-1 thymidine kinase/ganciclovir-mediated cytotoxicity in tumor cells.
Topics: Animals; Antiviral Agents; Cell Cycle; Cell Division; Cell Survival; Drug Resistance, Neoplasm; Eflo | 2003 |
In vivo enhancement of herpes simplex virus thymidine kinase/ganciclovir cancer gene therapy with polyamine biosynthesis inhibition.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Eflornithine; Female; Ganciclovir; Genes, Transgeni | 2006 |
Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO-PCV chemotherapy.
Topics: Anaplasia; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Disease Prog | 2007 |
Antitumor effects of vitamin A and inhibitors of ornithine decarboxylase in cultured neuroblastoma and glioma cells.
Topics: Animals; Antineoplastic Agents; Carboxy-Lyases; Cell Division; Cell Line; Drug Evaluation, Preclinic | 1980 |
Sensitization of 9L rat brain gliosarcoma cells to 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Cycle; Cell Line; Cell Survival; Dose-Response Relationsh | 1981 |
alpha-Difluoromethylornithine increases the anti-tumor effect of cis-diamminedichloroplatinum in G-XII rat glioma.
Topics: Acetyltransferases; Animals; Brain; Brain Neoplasms; Bromodeoxyuridine; Cell Movement; Cells, Cultur | 1995 |
Effect of D,L-alpha-difluoromethylornithine (DFMO) enhanced [3H]putrescine uptake on 9L tumor cell growth and colony forming efficiency.
Topics: Animals; Biological Transport; Brain Neoplasms; Cell Division; Eflornithine; Glioma; Kinetics; Putre | 1993 |
Difluoromethylornithine enhanced uptake of tritiated putrescine in 9L rat brain tumors.
Topics: Animals; Brain; Brain Neoplasms; Eflornithine; Glioma; Male; Ornithine Decarboxylase Inhibitors; Put | 1997 |
Effects of DFMO on glioma cell proliferation, migration and invasion in vitro.
Topics: Adult; Animals; Antineoplastic Agents; Cell Division; Cell Movement; Eflornithine; Female; Glioma; H | 1998 |
The effect of DFMO induced uptake of [3H] putrescine on human glioma cells.
Topics: Biological Transport; Brain Neoplasms; Cell Adhesion; Cell Division; Colony-Forming Units Assay; Efl | 2001 |
IGF-II mRNA expression in LI human glioblastoma cell line parallels cell growth.
Topics: Blotting, Northern; Brain Neoplasms; Eflornithine; Glioma; Growth Hormone-Releasing Hormone; Humans; | 1992 |
The additive effect of alpha-difluoromethylornithine (DFMO) and radiation therapy on a rat glioma model.
Topics: Animals; Biogenic Polyamines; Brain Neoplasms; Combined Modality Therapy; Disease Models, Animal; Ef | 1992 |
Growth inhibitory effect of recombinant alpha and beta interferon on human glioma cells.
Topics: Binding, Competitive; Cell Division; Cell Line; Eflornithine; Glioma; Humans; Interferon Type I; Put | 1987 |
Role of ornithine decarboxylase in the regulation of cell growth by IL-1 and tumor necrosis factor.
Topics: Animals; Cell Division; Cell Line; DNA; Eflornithine; Glioma; Growth Inhibitors; Humans; Interleukin | 1988 |
Effect of difluoromethylornithine on the antiglioma therapeutic efficacy of intra-arterial BCNU.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Eflornithine; | 1986 |