eflornithine has been researched along with Germinoblastoma in 13 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mitogenic stimulation of Nb2 lymphoma cells by lactogenic hormones (prolactin, human growth hormone) caused a dramatic early increase in ornithine decarboxylase (ODC) activity that achieved a maximal level by 6-8 h." | 7.67 | Role of ornithine decarboxylase in proliferation of prolactin-dependent lymphoma cells. ( Elsholtz, HP; Friesen, HG; Shiu, RP, 1986) |
| "Variant S49 mouse lymphoma cells with increased ornithine decarboxylase activity were obtained by selecting for resistance to alpha-difluoromethylornithine (DFMO), a specific inhibitor of the enzyme." | 7.66 | Ornithine decarboxylase in difluoromethylornithine-resistant mouse lymphoma cells. Two-dimensional gel analysis of synthesis and turnover. ( Coffino, P; McConlogue, L, 1983) |
| "Mutant mouse lymphoma cells that overproduce ornithine decarboxylase have been generated by selection for resistance to difluoromethylornithine, an inhibitor of the enzyme." | 7.66 | A mouse lymphoma cell mutant whose major protein product is ornithine decarboxylase. ( Coffino, P; McConlogue, L, 1983) |
| "Mitogenic stimulation of Nb2 lymphoma cells by lactogenic hormones (prolactin, human growth hormone) caused a dramatic early increase in ornithine decarboxylase (ODC) activity that achieved a maximal level by 6-8 h." | 3.67 | Role of ornithine decarboxylase in proliferation of prolactin-dependent lymphoma cells. ( Elsholtz, HP; Friesen, HG; Shiu, RP, 1986) |
| " Using murine lymphoma cells deficient in methylthioadenosine (MTA) phosphorylase, we have analyzed the role of MTA in the regulation of ornithine decarboxylase and S-adenosylmethionine (SAM) decarboxylase, the two rate-limiting enzymes in the polyamine-biosynthetic pathway." | 3.67 | Independent regulation of ornithine decarboxylase and S-adenosylmethionine decarboxylase in methylthioadenosine phosphorylase-deficient malignant murine lymphoblasts. ( Carson, DA; Kajander, EO; Kubota, M, 1985) |
| "Treatment of mouse lymphoma S49 cells with D,L-alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, depleted cellular polyamine levels and stopped cell growth." | 3.66 | Growth regulatory effects of cyclic AMP and polyamine depletion are dissociable in cultured mouse lymphoma cells. ( Coffino, P; Marton, LJ; McConlogue, LC, 1983) |
| "Variant S49 mouse lymphoma cells with increased ornithine decarboxylase activity were obtained by selecting for resistance to alpha-difluoromethylornithine (DFMO), a specific inhibitor of the enzyme." | 3.66 | Ornithine decarboxylase in difluoromethylornithine-resistant mouse lymphoma cells. Two-dimensional gel analysis of synthesis and turnover. ( Coffino, P; McConlogue, L, 1983) |
| "Mutant mouse lymphoma cells that overproduce ornithine decarboxylase have been generated by selection for resistance to difluoromethylornithine, an inhibitor of the enzyme." | 3.66 | A mouse lymphoma cell mutant whose major protein product is ornithine decarboxylase. ( Coffino, P; McConlogue, L, 1983) |
| "Lymphoma was induced in male PIM mice by a single intraperitoneal injection of 50 mg N-ethyl-N-nitrosourea (ENU) per kg body weight." | 1.29 | Comparative activity of N-(4-hydroxyphenyl)-all-trans-retinamide and alpha-difluoromethylornithine as inhibitors of lymphoma induction in PIM transgenic mice. ( Bowman-Gram, T; Johnson, WD; Kelloff, GJ; Lubet, RA; McCormick, DL; Rao, KV; Steele, VE, 1996) |
| "Putrescine has rather a counter-regulatory effect as concluded from the observation that the TPA-induced TCGF production and IL-2-specific mRNA expression are augmented (superinduced) by the ODC inhibitor D,L-alpha-difluoromethylornithine (DFMO) and again suppressed after the administration of putrescine or polyamines to DFMO-treated cultures." | 1.28 | Downregulation of T cell growth factor production by ornithine decarboxylase and its product putrescine: D,L-alpha-difluoromethylornithine suppresses general protein synthesis but augments simultaneously the production of interleukin-2. ( Dröge, W; Mihm, S; Oberdorfer, F; Risso, A; Stöhr, M, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (61.54) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nilsson, JA | 1 |
| Keller, UB | 1 |
| Baudino, TA | 1 |
| Yang, C | 1 |
| Norton, S | 1 |
| Old, JA | 1 |
| Nilsson, LM | 1 |
| Neale, G | 1 |
| Kramer, DL | 1 |
| Porter, CW | 1 |
| Cleveland, JL | 1 |
| McConlogue, LC | 1 |
| Marton, LJ | 1 |
| Coffino, P | 3 |
| McConlogue, L | 2 |
| McCormick, DL | 1 |
| Johnson, WD | 1 |
| Rao, KV | 1 |
| Bowman-Gram, T | 1 |
| Steele, VE | 1 |
| Lubet, RA | 1 |
| Kelloff, GJ | 1 |
| Singh, AB | 1 |
| Thomas, TJ | 1 |
| Thomas, T | 1 |
| Singh, M | 1 |
| Mann, RA | 1 |
| Wang, CC | 1 |
| Negreĭ, GZ | 1 |
| Ianish, IuV | 1 |
| Zavelevich, MP | 1 |
| Shliakhovenko, VA | 1 |
| Mihm, S | 1 |
| Risso, A | 1 |
| Stöhr, M | 1 |
| Oberdorfer, F | 1 |
| Dröge, W | 1 |
| Elsholtz, HP | 1 |
| Shiu, RP | 1 |
| Friesen, HG | 1 |
| Yamanaka, H | 1 |
| Kubota, M | 2 |
| Carson, DA | 2 |
| Kajander, EO | 1 |
| Ofenstein, JP | 1 |
| Rillema, JA | 1 |
| Lawson, DM | 1 |
13 other studies available for eflornithine and Germinoblastoma
| Article | Year |
|---|---|
Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation.
Topics: Animals; Apoptosis; B-Lymphocytes; Cell Cycle Proteins; Cell Proliferation; Cyclin-Dependent Kinase | 2005 |
Growth regulatory effects of cyclic AMP and polyamine depletion are dissociable in cultured mouse lymphoma cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Bucladesine; Cell Division; Cell Line; Cyclic AMP; Eflorn | 1983 |
Ornithine decarboxylase in difluoromethylornithine-resistant mouse lymphoma cells. Two-dimensional gel analysis of synthesis and turnover.
Topics: Animals; Carboxy-Lyases; Cell Line; Drug Resistance; Eflornithine; Electrophoresis, Polyacrylamide G | 1983 |
A mouse lymphoma cell mutant whose major protein product is ornithine decarboxylase.
Topics: Animals; Cell Division; Cell Line; Chromosome Banding; Eflornithine; Karyotyping; Kinetics; Lymphoma | 1983 |
Comparative activity of N-(4-hydroxyphenyl)-all-trans-retinamide and alpha-difluoromethylornithine as inhibitors of lymphoma induction in PIM transgenic mice.
Topics: Animals; Anticarcinogenic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Eflornit | 1996 |
Differential effects of polyamine homologues on the prevention of DL-alpha-difluoromethylornithine-mediated inhibition of malignant cell growth and normal immune response.
Topics: Animals; Cell Division; Cell Line; Concanavalin A; Cytotoxicity, Immunologic; Eflornithine; Isomeris | 1992 |
A novel suicide inhibitor strategy for antiparasitic drug development.
Topics: Amino Acid Sequence; Animals; Chimera; Cloning, Molecular; Eflornithine; Kinetics; Lymphoma; Mice; M | 1991 |
[The proliferative kinetics and acid-soluble proteins of the nuclear chromatin in tumor cells with a modified polyamine level].
Topics: Animals; Cell Division; Cell Nucleus; Chromatin; Eflornithine; Electrophoresis, Polyacrylamide Gel; | 1990 |
Downregulation of T cell growth factor production by ornithine decarboxylase and its product putrescine: D,L-alpha-difluoromethylornithine suppresses general protein synthesis but augments simultaneously the production of interleukin-2.
Topics: Adjuvants, Immunologic; Animals; Cell Line; Eflornithine; Glycolysis; Interleukin-2; Intracellular F | 1989 |
Role of ornithine decarboxylase in proliferation of prolactin-dependent lymphoma cells.
Topics: Animals; Cell Division; Cell Line; Eflornithine; Growth Hormone; Humans; Kinetics; Lymphoma; Ornithi | 1986 |
Synergistic inhibition of polyamine synthesis and growth by difluoromethylornithine plus methylthioadenosine in methylthioadenosine phosphorylase-deficient murine lymphoma cells.
Topics: Adenosine; Animals; Cell Division; Cell Line; Deoxyadenosines; Drug Synergism; Eflornithine; Kinetic | 1987 |
Independent regulation of ornithine decarboxylase and S-adenosylmethionine decarboxylase in methylthioadenosine phosphorylase-deficient malignant murine lymphoblasts.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cell Line; Deoxyadenosines; Ef | 1985 |
Prolactin stimulation of Nb 2 node lymphoma cell division is inhibited by polyamine biosynthesis inhibitors.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; Cell Line; Drug Interactions; Eflornithine | 1985 |