eflornithine has been researched along with Fibrosarcoma in 5 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Fibrosarcoma: A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Rats bearing a subcutaneous fibrosarcoma were randomized to receive a chow diet (n = 5), TPN (n = 5), or TPN + difluoromethylornithine (DFMO) (an irreversible inhibitor of ornithine decarboxylase (ODC), at 1000 mg/kg body wt/day n = 4) for 6 days by continuous central venous infusion." | 3.67 | Effect of difluoromethylornithine on host and tumor polyamine metabolism during total parenteral nutrition. ( Ajani, JA; Chang, T; Grossie, VB; Harris, WB; Nishioka, K; Ota, DM; Patenia, D, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fadok, VA | 1 |
| Daleke, DL | 1 |
| Henson, PM | 1 |
| Bratton, DL | 1 |
| Hessels, J | 1 |
| Kingma, AW | 1 |
| Muskiet, FA | 1 |
| Sarhan, S | 1 |
| Seiler, N | 1 |
| Grossie, VB | 3 |
| Ota, DM | 3 |
| Ajani, JA | 3 |
| Nishioka, K | 3 |
| Patenia, D | 2 |
| Chang, TH | 1 |
| Harris, WB | 1 |
| Chang, T | 1 |
5 other studies available for eflornithine and Fibrosarcoma
| Article | Year |
|---|---|
Loss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblasts.
Topics: Animals; Apoptosis; Bone Marrow Cells; Calcitriol; Cell Differentiation; Cell Survival; Eflornithine | 2001 |
Growth inhibition of two solid tumors in mice, caused by polyamine depletion, is not attended by alterations in cell-cycle phase distribution.
Topics: Animals; Cell Cycle; Cell Division; Eflornithine; Female; Fibrosarcoma; Kinetics; Lung Neoplasms; Mi | 1991 |
Effect of intravenous alpha-difluoromethylornithine on the polyamine levels of normal tissue and a transplantable fibrosarcoma.
Topics: Animals; Eflornithine; Fibrosarcoma; Infusions, Intravenous; Kidney; Kinetics; Liver; Male; Ornithin | 1987 |
Polyamine-directed preferential nutritional repletion of normal tissues in tumor-bearing hosts.
Topics: Animals; Body Weight; Eflornithine; Erythrocytes; Fibrosarcoma; Methylcholanthrene; Nutrition Disord | 1988 |
Effect of difluoromethylornithine on host and tumor polyamine metabolism during total parenteral nutrition.
Topics: Animals; Eflornithine; Erythrocytes; Fibrosarcoma; Liver; Male; Ornithine; Ornithine Decarboxylase I | 1985 |