eflornithine has been researched along with EHS Tumor in 8 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The dose limiting toxicity of difluoromethylornithine (DFMO), when administered by continuous infusion, is thrombocytopenia." | 7.68 | Amelioration of thrombocytopenia with concomitant ornithine in sarcoma-bearing rats receiving high dose difluoromethylornithine. ( Ajani, JA; Grossie, VB; Nishioka, K; Ota, DM, 1991) |
| "The purpose of this study was to evaluate the effect of a concomitant infusion of ornithine on the difluoromethylornithine (DFMO)-induced thrombocytopenia and antitumor activity." | 7.67 | Reduction of difluoromethylornithine-induced thrombocytopenia in rats with ornithine while maintaining antitumor activity. ( Ajani, JA; Chang, TH; Grossie, VB; Nishioka, K; Ota, DM; Patenia, D, 1989) |
| "The dose limiting toxicity of difluoromethylornithine (DFMO), when administered by continuous infusion, is thrombocytopenia." | 3.68 | Amelioration of thrombocytopenia with concomitant ornithine in sarcoma-bearing rats receiving high dose difluoromethylornithine. ( Ajani, JA; Grossie, VB; Nishioka, K; Ota, DM, 1991) |
| "The purpose of this study was to evaluate the effect of a concomitant infusion of ornithine on the difluoromethylornithine (DFMO)-induced thrombocytopenia and antitumor activity." | 3.67 | Reduction of difluoromethylornithine-induced thrombocytopenia in rats with ornithine while maintaining antitumor activity. ( Ajani, JA; Chang, TH; Grossie, VB; Nishioka, K; Ota, DM; Patenia, D, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 7 (87.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lehnert, T | 1 |
| Buhl, K | 1 |
| Ivankovic, S | 1 |
| Westin, T | 1 |
| Soussi, B | 1 |
| Idström, JP | 1 |
| Lindnér, P | 1 |
| Edström, S | 1 |
| Lydén, E | 1 |
| Gustavsson, B | 1 |
| Hafström, L | 1 |
| Lundholm, K | 1 |
| Takeshita, S | 1 |
| Nagatomi, H | 1 |
| Ando, K | 1 |
| Grossie, VB | 2 |
| Ota, DM | 2 |
| Ajani, JA | 2 |
| Nishioka, K | 2 |
| Ljunggren, O | 1 |
| Fredholm, BB | 1 |
| Lerner, UH | 1 |
| Alison, MR | 1 |
| Sarraf, CE | 1 |
| Emons, VE | 1 |
| Hill, SA | 1 |
| Maghsoudloo, M | 1 |
| Murphy, GM | 1 |
| Hessels, J | 1 |
| Kingma, AW | 1 |
| Muskiet, FA | 1 |
| Sarhan, S | 1 |
| Seiler, N | 1 |
| Chang, TH | 1 |
| Patenia, D | 1 |
8 other studies available for eflornithine and EHS Tumor
| Article | Year |
|---|---|
Inhibition of gastric tumorigenesis by alpha-difluoromethylornithine in rats treated with N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Adenocarcinoma; Adenoma; Animals; Cell Transformation, Neoplastic; Duodenal Neoplasms; Eflornithine; | 1993 |
Energetics of nutrition and polyamine-related tumor growth alterations in experimental cancer.
Topics: Adenosine Triphosphate; Animals; Eating; Eflornithine; Energy Metabolism; Female; Magnetic Resonance | 1993 |
Alleviation of intestinal lesions by combined treatment with a 5-fluoro-2'-deoxyuridine (FUDR) derivative and alpha-difluoromethylornithine (DFMO)[correction of DMFO] in tumor-bearing mice.
Topics: Amine Oxidase (Copper-Containing); Animals; Antineoplastic Combined Chemotherapy Protocols; Body Wei | 1992 |
Amelioration of thrombocytopenia with concomitant ornithine in sarcoma-bearing rats receiving high dose difluoromethylornithine.
Topics: Animals; Biogenic Polyamines; Drug Therapy, Combination; Eflornithine; Kidney; Liver; Male; Ornithin | 1991 |
On the role of polyamines in bone resorption induced by parathyroid hormone.
Topics: Animals; Bone Neoplasms; Bone Resorption; Calcium; Eflornithine; Mice; Ornithine Decarboxylase; Para | 1991 |
Effect of alpha-difluoromethylornithine on the polyamine levels and proliferation in two transplantable tumours.
Topics: Animals; Cell Division; Cell Nucleus; Eflornithine; Female; Mammary Neoplasms, Experimental; Mice; M | 1991 |
Growth inhibition of two solid tumors in mice, caused by polyamine depletion, is not attended by alterations in cell-cycle phase distribution.
Topics: Animals; Cell Cycle; Cell Division; Eflornithine; Female; Fibrosarcoma; Kinetics; Lung Neoplasms; Mi | 1991 |
Reduction of difluoromethylornithine-induced thrombocytopenia in rats with ornithine while maintaining antitumor activity.
Topics: Animals; Biogenic Polyamines; Eflornithine; Male; Ornithine; Rats; Rats, Inbred F344; Sarcoma, Exper | 1989 |