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eflornithine and EHS Tumor

eflornithine has been researched along with EHS Tumor in 8 studies

Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.

Research Excerpts

ExcerptRelevanceReference
"The dose limiting toxicity of difluoromethylornithine (DFMO), when administered by continuous infusion, is thrombocytopenia."7.68Amelioration of thrombocytopenia with concomitant ornithine in sarcoma-bearing rats receiving high dose difluoromethylornithine. ( Ajani, JA; Grossie, VB; Nishioka, K; Ota, DM, 1991)
"The purpose of this study was to evaluate the effect of a concomitant infusion of ornithine on the difluoromethylornithine (DFMO)-induced thrombocytopenia and antitumor activity."7.67Reduction of difluoromethylornithine-induced thrombocytopenia in rats with ornithine while maintaining antitumor activity. ( Ajani, JA; Chang, TH; Grossie, VB; Nishioka, K; Ota, DM; Patenia, D, 1989)
"The dose limiting toxicity of difluoromethylornithine (DFMO), when administered by continuous infusion, is thrombocytopenia."3.68Amelioration of thrombocytopenia with concomitant ornithine in sarcoma-bearing rats receiving high dose difluoromethylornithine. ( Ajani, JA; Grossie, VB; Nishioka, K; Ota, DM, 1991)
"The purpose of this study was to evaluate the effect of a concomitant infusion of ornithine on the difluoromethylornithine (DFMO)-induced thrombocytopenia and antitumor activity."3.67Reduction of difluoromethylornithine-induced thrombocytopenia in rats with ornithine while maintaining antitumor activity. ( Ajani, JA; Chang, TH; Grossie, VB; Nishioka, K; Ota, DM; Patenia, D, 1989)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19901 (12.50)18.7374
1990's7 (87.50)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lehnert, T1
Buhl, K1
Ivankovic, S1
Westin, T1
Soussi, B1
Idström, JP1
Lindnér, P1
Edström, S1
Lydén, E1
Gustavsson, B1
Hafström, L1
Lundholm, K1
Takeshita, S1
Nagatomi, H1
Ando, K1
Grossie, VB2
Ota, DM2
Ajani, JA2
Nishioka, K2
Ljunggren, O1
Fredholm, BB1
Lerner, UH1
Alison, MR1
Sarraf, CE1
Emons, VE1
Hill, SA1
Maghsoudloo, M1
Murphy, GM1
Hessels, J1
Kingma, AW1
Muskiet, FA1
Sarhan, S1
Seiler, N1
Chang, TH1
Patenia, D1

Other Studies

8 other studies available for eflornithine and EHS Tumor

ArticleYear
Inhibition of gastric tumorigenesis by alpha-difluoromethylornithine in rats treated with N-methyl-N'-nitro-N-nitrosoguanidine.
    Journal of cancer research and clinical oncology, 1993, Volume: 119, Issue:10

    Topics: Adenocarcinoma; Adenoma; Animals; Cell Transformation, Neoplastic; Duodenal Neoplasms; Eflornithine;

1993
Energetics of nutrition and polyamine-related tumor growth alterations in experimental cancer.
    British journal of cancer, 1993, Volume: 68, Issue:4

    Topics: Adenosine Triphosphate; Animals; Eating; Eflornithine; Energy Metabolism; Female; Magnetic Resonance

1993
Alleviation of intestinal lesions by combined treatment with a 5-fluoro-2'-deoxyuridine (FUDR) derivative and alpha-difluoromethylornithine (DFMO)[correction of DMFO] in tumor-bearing mice.
    Biochemical pharmacology, 1992, Mar-17, Volume: 43, Issue:6

    Topics: Amine Oxidase (Copper-Containing); Animals; Antineoplastic Combined Chemotherapy Protocols; Body Wei

1992
Amelioration of thrombocytopenia with concomitant ornithine in sarcoma-bearing rats receiving high dose difluoromethylornithine.
    Investigational new drugs, 1991, Volume: 9, Issue:4

    Topics: Animals; Biogenic Polyamines; Drug Therapy, Combination; Eflornithine; Kidney; Liver; Male; Ornithin

1991
On the role of polyamines in bone resorption induced by parathyroid hormone.
    Acta physiologica Scandinavica, 1991, Volume: 142, Issue:2

    Topics: Animals; Bone Neoplasms; Bone Resorption; Calcium; Eflornithine; Mice; Ornithine Decarboxylase; Para

1991
Effect of alpha-difluoromethylornithine on the polyamine levels and proliferation in two transplantable tumours.
    Virchows Archiv. A, Pathological anatomy and histopathology, 1991, Volume: 419, Issue:3

    Topics: Animals; Cell Division; Cell Nucleus; Eflornithine; Female; Mammary Neoplasms, Experimental; Mice; M

1991
Growth inhibition of two solid tumors in mice, caused by polyamine depletion, is not attended by alterations in cell-cycle phase distribution.
    International journal of cancer, 1991, Jul-09, Volume: 48, Issue:5

    Topics: Animals; Cell Cycle; Cell Division; Eflornithine; Female; Fibrosarcoma; Kinetics; Lung Neoplasms; Mi

1991
Reduction of difluoromethylornithine-induced thrombocytopenia in rats with ornithine while maintaining antitumor activity.
    Cancer research, 1989, Aug-01, Volume: 49, Issue:15

    Topics: Animals; Biogenic Polyamines; Eflornithine; Male; Ornithine; Rats; Rats, Inbred F344; Sarcoma, Exper

1989