eflornithine has been researched along with Distorted Hearing in 6 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Eflornithine was offered as compassionate treatment of 33 episodes of Pneumocystis carinii pneumonia in 31 patients with acquired immunodeficiency syndrome who were intolerant of and/or unresponsive to conventional trimethoprim-sulfamethoxazole or pentamidine therapy." | 7.68 | Eflornithine treatment of refractory Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome. ( Boylen, CT; Gilman, TM; Heseltine, PN; Paulson, YJ; Sharma, OP, 1992) |
| "Eflornithine was offered as compassionate treatment of 33 episodes of Pneumocystis carinii pneumonia in 31 patients with acquired immunodeficiency syndrome who were intolerant of and/or unresponsive to conventional trimethoprim-sulfamethoxazole or pentamidine therapy." | 3.68 | Eflornithine treatment of refractory Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome. ( Boylen, CT; Gilman, TM; Heseltine, PN; Paulson, YJ; Sharma, OP, 1992) |
| "Patients with resected superficial bladder cancers were studied." | 2.68 | Toxicity evaluation of difluoromethylornithine: doses for chemoprevention trials. ( Loprinzi, CL; Love, RR; Messing, EM; Morton, RF; Novotny, P; O'Fallon, JR; Poon, MA; Quella, SK; Trump, DL, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 5 (83.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Loprinzi, CL | 1 |
| Messing, EM | 1 |
| O'Fallon, JR | 1 |
| Poon, MA | 1 |
| Love, RR | 2 |
| Quella, SK | 1 |
| Trump, DL | 1 |
| Morton, RF | 1 |
| Novotny, P | 1 |
| Pasic, TR | 1 |
| Heisey, D | 1 |
| Paulson, YJ | 1 |
| Gilman, TM | 1 |
| Heseltine, PN | 1 |
| Sharma, OP | 1 |
| Boylen, CT | 1 |
| Croghan, MK | 1 |
| Aickin, MG | 1 |
| Meyskens, FL | 1 |
| Marks, SC | 1 |
| Mattox, DE | 1 |
| Casero, RA | 1 |
| Schweitzer, L | 1 |
| Casseday, JH | 1 |
| Sjoerdsma, A | 1 |
| McCann, PP | 1 |
| Bartolome, JV | 1 |
2 trials available for eflornithine and Distorted Hearing
| Article | Year |
|---|---|
Toxicity evaluation of difluoromethylornithine: doses for chemoprevention trials.
Topics: Antineoplastic Agents; Carcinoma, Transitional Cell; Chemoprevention; Dose-Response Relationship, Dr | 1996 |
alpha-difluoromethylornithine ototoxicity. Chemoprevention clinical trial results.
Topics: Anticarcinogenic Agents; Audiometry; Auditory Threshold; Clinical Trials, Phase I as Topic; Clinical | 1997 |
4 other studies available for eflornithine and Distorted Hearing
| Article | Year |
|---|---|
Eflornithine treatment of refractory Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Eflornithine; Female; Hearing Disorders; Humans; Male; Pn | 1992 |
Dose-related alpha-difluoromethylornithine ototoxicity.
Topics: Adolescent; Adult; Age Factors; Aged; Audiometry; Dose-Response Relationship, Drug; Drug Evaluation; | 1991 |
The effects of DFMO on polyamine metabolism in the inner ear.
Topics: Animals; Ear, Inner; Eflornithine; Guinea Pigs; Hearing; Hearing Disorders; Male; Ornithine Decarbox | 1991 |
Identification of polyamines in the cochlea of the rat and their potential role in hearing.
Topics: Animals; Auditory Threshold; Cochlea; Eflornithine; Hearing; Hearing Disorders; Male; Ornithine; Orn | 1986 |