eflornithine has been researched along with Diarrhea in 5 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-two patients with the acquired immune deficiency syndrome (AIDS) and severe debilitating diarrhea caused by Cryptosporidium received eflornithine as therapy." | 3.67 | Intestinal crytosporidiosis treated with eflornithine: a prospective study among patients with AIDS. ( Bodey, GP; Fainstein, V; Rolston, KV, 1989) |
| "Subacute (2 week) oral or intravenous administration of DL-alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), caused diarrhea and frequent emesis as early as 4 to 5 days in dogs (dose greater than or equal to 200 mg/kg/day)." | 3.66 | Intestinal changes caused by DL-alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase. ( Diekema, KA; Gibson, JP; Loudy, DE; McCann, PP; Sprinkle, DJ; Yarrington, JT, 1983) |
| " This open trial shows that DFMO is as active as and possibly less toxic than melarsoprol." | 2.67 | Efficacy and toxicity of eflornithine for treatment of Trypanosoma brucei gambiense sleeping sickness. ( Ethier, L; Loko, L; Milord, F; Mpia, B; Pépin, J, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Warrell, RP | 1 |
| Burchenal, JH | 1 |
| Yarrington, JT | 1 |
| Sprinkle, DJ | 1 |
| Loudy, DE | 1 |
| Diekema, KA | 1 |
| McCann, PP | 1 |
| Gibson, JP | 1 |
| Milord, F | 2 |
| Pépin, J | 2 |
| Loko, L | 1 |
| Ethier, L | 1 |
| Mpia, B | 1 |
| Rolston, KV | 1 |
| Fainstein, V | 1 |
| Bodey, GP | 1 |
| Guern, C | 1 |
| Schechter, PJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563] | Phase 2 | 70 participants (Anticipated) | Interventional | 2023-03-14 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for eflornithine and Diarrhea
| Article | Year |
|---|---|
Methylglyoxal-bis(guanylhydrazone) (Methyl-GAG): current status and future prospects.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemical Phenomena; Chemistry; Clinical Tri | 1983 |
2 trials available for eflornithine and Diarrhea
| Article | Year |
|---|---|
Methylglyoxal-bis(guanylhydrazone) (Methyl-GAG): current status and future prospects.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemical Phenomena; Chemistry; Clinical Tri | 1983 |
Efficacy and toxicity of eflornithine for treatment of Trypanosoma brucei gambiense sleeping sickness.
Topics: Administration, Oral; Animals; Cerebrospinal Fluid; Democratic Republic of the Congo; Diarrhea; Eflo | 1992 |
3 other studies available for eflornithine and Diarrhea
| Article | Year |
|---|---|
Intestinal changes caused by DL-alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase.
Topics: Animals; Depression, Chemical; Diarrhea; Dogs; Eflornithine; Female; Intestinal Absorption; Intestin | 1983 |
Intestinal crytosporidiosis treated with eflornithine: a prospective study among patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; Cryptosporidiosis; Diarrhea; Eflornithine; Female; Humans | 1989 |
Difluoromethylornithine for arseno-resistant Trypanosoma brucei gambiense sleeping sickness.
Topics: Administration, Oral; Adolescent; Animals; Arsenicals; Child; Child, Preschool; Diarrhea; Drug Resis | 1987 |