eflornithine has been researched along with Diabetes Mellitus, Type 1 in 4 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The underlying pathophysiology of type 1 diabetes involves autoimmune-mediated islet inflammation, leading to dysfunction and death of insulin-secreting islet β cells." | 1.40 | Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy. ( Colvin, SC; Maier, B; Mirmira, RG; Tersey, SA, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sims, EK | 1 |
| Kulkarni, A | 1 |
| Hull, A | 1 |
| Woerner, SE | 1 |
| Cabrera, S | 1 |
| Mastrandrea, LD | 1 |
| Hammoud, B | 1 |
| Sarkar, S | 1 |
| Nakayasu, ES | 1 |
| Mastracci, TL | 1 |
| Perkins, SM | 1 |
| Ouyang, F | 1 |
| Webb-Robertson, BJ | 1 |
| Enriquez, JR | 1 |
| Tersey, SA | 2 |
| Evans-Molina, C | 1 |
| Long, SA | 1 |
| Blanchfield, L | 1 |
| Gerner, EW | 1 |
| Mirmira, RG | 2 |
| DiMeglio, LA | 1 |
| Colvin, SC | 1 |
| Maier, B | 1 |
| Satriano, J | 1 |
| Parekh, VV | 1 |
| Hoffman, JL | 1 |
| Younoszai, MK | 1 |
1 review available for eflornithine and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Kidney growth, hypertrophy and the unifying mechanism of diabetic complications.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; Cell Cycle Proteins; Cyclin-Depende | 2007 |
1 trial available for eflornithine and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Inhibition of polyamine biosynthesis preserves β cell function in type 1 diabetes.
Topics: Animals; Diabetes Mellitus, Type 1; Eflornithine; Humans; Mice; Ornithine Decarboxylase; Ornithine D | 2023 |
2 other studies available for eflornithine and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Dose-Re | 2014 |
Role of tyrosine kinase, ODC, and p34cdc2 kinase and cyclin B-associated cdc2 in jejunal enterocyte proliferation, maturation, and exfoliation in diabetic and DFMO-treated rats.
Topics: Animals; Biomarkers; CDC2 Protein Kinase; Cell Division; Cyclin B; Cyclin-Dependent Kinase-Activatin | 1999 |