eflornithine has been researched along with Dermatitis in 1 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Dermatitis: Any inflammation of the skin.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Chronic administration (52 weeks) by gavage to Charles River CD rats at dosages of 400, 800, and 1600 mg/kg produced weight loss, increased platelets, alopecia and skin abrasions, dermatitis, liver necrosis, and gastric inflammation." | 1.29 | Chronic toxicity studies of the potential cancer preventive 2-(difluoromethyl)-dl-ornithine. ( Boone, CW; Crowell, JA; Goldenthal, EI; Kelloff, GJ; Malone, WF, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Crowell, JA | 1 |
| Goldenthal, EI | 1 |
| Kelloff, GJ | 1 |
| Malone, WF | 1 |
| Boone, CW | 1 |
1 other study available for eflornithine and Dermatitis
| Article | Year |
|---|---|
Chronic toxicity studies of the potential cancer preventive 2-(difluoromethyl)-dl-ornithine.
Topics: Animals; Anticarcinogenic Agents; Blood Cell Count; Blood Chemical Analysis; Body Weight; Cell Divis | 1994 |