eflornithine has been researched along with Deafness in 6 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Deafness: A general term for the complete loss of the ability to hear from both ears.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Previous neonatal gerbil studies have identified a dosing regimen of 1 g/kg per day of DFMO given for 3 weeks that results in reversible HL on click-evoked auditory brainstem response (ABR)." | 1.32 | Difluoromethylornithine-induced reversible hearing loss across a wide frequency range. ( Doyle, KJ; Smith, MC; Tinling, S, 2004) |
| " The objectives of these three experiments were to: 1) determine a dose and dosing schedule of DFMO that produces significant hearing loss (HL) in newborn gerbils; 2) compare the HL level for control and newborn gerbils receiving daily subcutaneous injections of DFMO; and 3) to determine if DFMO-related HL is significantly reversible following discontinuation of DFMO treatment." | 1.31 | Delayed, reversible hearing loss caused by difluoromethylornithine (DFMO). ( Doyle, KJ, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, X | 1 |
| Levic, S | 1 |
| Gratton, MA | 1 |
| Doyle, KJ | 4 |
| Yamoah, EN | 1 |
| Pegg, AE | 1 |
| Smith, MC | 1 |
| Tinling, S | 1 |
| McWilliams, ML | 1 |
| Chen, GD | 1 |
| Fechter, LD | 1 |
| McLaren, CE | 1 |
| Shanks, JE | 1 |
| Galus, CM | 1 |
| Meyskens, FL | 1 |
| Splinter, TA | 1 |
| Romijn, JC | 1 |
1 trial available for eflornithine and Deafness
| Article | Year |
|---|---|
Effects of difluoromethylornithine chemoprevention on audiometry thresholds and otoacoustic emissions.
Topics: Antineoplastic Agents; Audiometry, Pure-Tone; Auditory Threshold; Colonic Polyps; Colorectal Neoplas | 2001 |
5 other studies available for eflornithine and Deafness
| Article | Year |
|---|---|
Spermine synthase deficiency leads to deafness and a profound sensitivity to alpha-difluoromethylornithine.
Topics: Animals; Body Weight; Deafness; Eflornithine; Enzyme Inhibitors; Female; Male; Mice; Spermine Syntha | 2009 |
Difluoromethylornithine-induced reversible hearing loss across a wide frequency range.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antineoplastic Agents; Auditory Threshold; Deafness | 2004 |
Characterization of the ototoxicity of difluoromethylornithine and its enantiomers.
Topics: Animals; Auditory Threshold; Deafness; Eflornithine; Enzyme Inhibitors; Guinea Pigs; Hair Cells, Aud | 2000 |
Delayed, reversible hearing loss caused by difluoromethylornithine (DFMO).
Topics: Animals; Animals, Newborn; Antineoplastic Agents; Deafness; Eflornithine; Evoked Potentials, Auditor | 2001 |
Phase I study of alpha-difluoromethylornithine and methyl-GAG.
Topics: Adolescent; Adult; Aged; Anemia, Hemolytic; Antineoplastic Combined Chemotherapy Protocols; Deafness | 1986 |