eflornithine has been researched along with Cytomegalovirus in 3 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Cytomegalovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Both the nucleoside analog 9[(1,3-dihydroxy-2-propoxy)methyl]guanine (ganciclovir; DHPG) and the polyamine synthesis inhibitor difluoromethylornithine (DFMO) have been reported to inhibit replication of cytomegalovirus (CMV) in vitro." | 3.67 | Effect of combinations of difluoromethylornithine (DFMO) and 9[(1,3-dihydroxy-2-propoxy) methyl]guanine (DHPG) on human cytomegalovirus. ( Mills, J; Rush, J, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tyms, AS | 1 |
| Williamson, JD | 1 |
| Gibson, W | 1 |
| van Breemen, R | 1 |
| Fields, A | 1 |
| LaFemina, R | 1 |
| Irmiere, A | 1 |
| Rush, J | 1 |
| Mills, J | 1 |
3 other studies available for eflornithine and Cytomegalovirus
| Article | Year |
|---|---|
Inhibitors of polyamine biosynthesis block human cytomegalovirus replication.
Topics: Antiviral Agents; Cells, Cultured; Cytomegalovirus; Eflornithine; Guanidines; Humans; Mitoguazone; O | 1982 |
D,L-alpha-difluoromethylornithine inhibits human cytomegalovirus replication.
Topics: Cells, Cultured; Cytomegalovirus; DNA, Viral; Eflornithine; Humans; Male; Ornithine; Ornithine Decar | 1984 |
Effect of combinations of difluoromethylornithine (DFMO) and 9[(1,3-dihydroxy-2-propoxy) methyl]guanine (DHPG) on human cytomegalovirus.
Topics: Acyclovir; Cells, Cultured; Cytomegalovirus; Drug Synergism; Eflornithine; Fibroblasts; Ganciclovir; | 1987 |