Page last updated: 2024-10-25

eflornithine and Colonic Neoplasms

eflornithine has been researched along with Colonic Neoplasms in 80 studies

Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.

Colonic Neoplasms: Tumors or cancer of the COLON.

Research Excerpts

ExcerptRelevanceReference
"We have investigated effects of alpha-difluoromethylornithine (DFMO), both as a single agent and in combination with 5-fluorouracil (5-FU) against a human colon tumor xenograft (T6) grown as primary tissue culture in serum-free medium and in combination with doxorubicin (DX) against a human lung adenocarcinoma cell line (A549)."7.68In vitro response of a human colon tumor xenograft and a lung adenocarcinoma cell line to alpha-difluoromethylornithine alone and in combination with 5-fluorouracil and doxorubicin. ( Atabek, U; Zirvi, KA, 1991)
"A phase III clinical trial assessed the recurrence of adenomatous polyps after treatment for 36 months with difluoromethylornithine (DFMO) plus sulindac or matched placebos."5.13Longitudinal assessment of air conduction audiograms in a phase III clinical trial of difluoromethylornithine and sulindac for prevention of sporadic colorectal adenomas. ( Chen, WP; Fujikawa-Brooks, S; Gerner, EW; Gillen, DL; McLaren, CE; Meyskens, FL; Pelot, D, 2008)
"We have investigated effects of alpha-difluoromethylornithine (DFMO), both as a single agent and in combination with 5-fluorouracil (5-FU) against a human colon tumor xenograft (T6) grown as primary tissue culture in serum-free medium and in combination with doxorubicin (DX) against a human lung adenocarcinoma cell line (A549)."3.68In vitro response of a human colon tumor xenograft and a lung adenocarcinoma cell line to alpha-difluoromethylornithine alone and in combination with 5-fluorouracil and doxorubicin. ( Atabek, U; Zirvi, KA, 1991)
" The dosage of PXM 10 mg q."2.69Phase I chemoprevention study of piroxicam and alpha-difluoromethylornithine. ( Blair, IA; Carbone, PP; Douglas, JA; Larson, PO; Pomplun, M; Tutsch, KD; Verma, AK, 1998)
" DFMO has shown a dose-response effect in tumor inhibition in mice."2.67Randomized phase I chemoprevention dose-seeking study of alpha-difluoromethylornithine. ( Carbone, PP; Carey, P; Gilmore, D; Love, RR; Pomplun, M; Tutsch, KD; Verma, AK; Wilding, G, 1993)
"In spite of improvements in care of colon cancer patients, prevention may enable potential patients to avoid cancer therapy."2.45Nutrition and colon cancer prevention. ( Marshall, JR, 2009)
"Recent clinical cancer chemoprevention trials, using dose de-escalation designs, indicate that DFMO can be given over long periods of time at low doses that suppress polyamine contents in gastrointestinal and other epithelial tissues but cause no detectable hearing loss or other side effects."2.40Development of difluoromethylornithine (DFMO) as a chemoprevention agent. ( Gerner, EW; Meyskens, FL, 1999)
"As case study, colon cancer HT-29 cells, a human cell model to investigate colon cancer, are employed."1.42Metabolomics of adherent mammalian cells by capillary electrophoresis-mass spectrometry: HT-29 cells as case study. ( Campone, L; Cifuentes, A; García-Cañas, V; Ibáñez, C; Piccinelli, AL; Simó, C; Valdés, A, 2015)
"Phospho-sulindac (PS; OXT-328) prevents colon cancer in mice, especially when combined with difluoromethylornithine (DFMO)."1.38The metabolism and pharmacokinetics of phospho-sulindac (OXT-328) and the effect of difluoromethylornithine. ( Alston, N; Constantinides, PP; Huang, L; Kopelovich, L; Mackenzie, GG; Murray, OT; Nie, T; Ouyang, N; Rigas, B; Sun, Y; Xie, G; Zhu, C, 2012)
" Study results show that P-S/DFMO is an efficacious drug combination for colon cancer prevention and also show the safety of P-S, which may overcome the limiting side effects of conventional sulindac."1.37Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice. ( Huang, L; Komninou, D; Kopelovich, L; Mackenzie, GG; Ouyang, N; Rigas, B; Sun, Y; Vrankova, K; Xie, G, 2011)
" However, chronic administration of NSAIDs is associated with significant side effects, mainly of the gastrointestinal tract."1.36Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice. ( Gupta, RC; Huang, L; Johnson, F; Komninou, D; Kopelovich, L; Mackenzie, GG; Ouyang, N; Rigas, B; Sun, Y; Xie, G, 2010)
"Clinical familial adenomatous polyposis (FAP) syndrome represents a high risk pre-invasive precursor for colon cancer, and is characterized by germ line mutation in the adenomatous polyposis coli (APC) tumor suppressor gene."1.35Novel cell culture model for prevention of carcinogenic risk in familial adenomatous polyposis syndrome. ( Katdare, M; Telang, N, 2009)
"The majority of colon cancers have somatic mutations in the APC (adenomatous polyposis coli) tumour-suppressor gene."1.34Impact of dietary amino acids and polyamines on intestinal carcinogenesis and chemoprevention in mouse models. ( Gerner, EW, 2007)
"Hence, agents that prevented colon cancer decreased the mitotic index and altered the expression of c-myc, p16 and p27 suggesting that modulation in the expression of these genes are potential biomarkers for chemopreventive activity."1.31Altered expression of c-myc, p16 and p27 in rat colon tumors and its reversal by short-term treatment with chemopreventive agents. ( Kramer, PM; Lubet, RA; Pereira, MA; Steele, VE; Tao, L; Wang, W; Yang, S, 2002)
"The dose-response relationship in male F344 rats was determined for the ability of aspirin administered in the diet to prevent azoxymethane (AOM)-induced colon cancer and aberrant crypt foci (ACF) and to reduce prostaglandin E2 (PGE2) levels."1.30Prevention by aspirin and its combination with alpha-difluoromethylornithine of azoxymethane-induced tumors, aberrant crypt foci and prostaglandin E2 levels in rat colon. ( Conran, P; Hawk, EE; Kelloff, GJ; Kramer, PM; Li, H; Lubet, RA; Pereira, MA; Schut, HA; Steele, VE, 1999)
"Rat colon neoplasms are distributed 60% in the distal colon (DC) and 40% in the proximal colon (PC), similar to distribution of colon cancers in the industrialized world."1.29Regional chemoprevention of carcinogen-induced tumors in rat colon. ( Holt, PR; Liu, T; Mokuolu, AO; Rao, CV; Reddy, BS, 1995)
"once weekly for 20 wk to induce colon cancer."1.28Reduced growth rate of dimethylhydrazine-induced colon tumors in rats. ( Koike, T; Shibusawa, M; Tsunoda, A; Tsunoda, Y; Yasuda, N, 1992)
"A human colon cancer cell line Hce-8693 was heterotransplanted in nude mice."1.28[Inhibition by polyamine biosynthesis inhibitor DFMO of the growth of transplanted human colon cancer in nude mice]. ( Wang, M, 1991)
" The dose-response curve for ODC activation by VIP indicates an EC50 value of 0."1.28Involvement of ornithine decarboxylase in the control of proliferation of the HT29 human colon cancer cell line. Effect of vasoactive intestinal peptide on enzyme activity. ( Cazenave, Y; Denis-Pouxviel, C; Gamet, L; Murat, JC; Trocheris, V, 1991)
"Flavone acetic acid (FAA) is a novel antitumor agent which appears to work through a different mechanism than the conventional chemotherapeutic agents."1.28Combination of flavone acetic acid (FAA) with adriamycin, cis-platinum and difluoromethylornithine (DFMO) in vitro against human colon cancer cells. ( Bernabei, A; Corbett, TH; Freedland, C; Luk, GD; Neelam, SS; Thompson, R, 1990)
"Throughout the experiment, 50 colon cancers developed in 16 DMH-treated mice (mean, 3."1.27Inhibition of ornithine decarboxylase with 2-difluoromethylornithine: reduced incidence of dimethylhydrazine-induced colon tumors in mice. ( Diekema, KA; King, WW; Kingsnorth, AN; Malt, RA; McCann, PP; Ross, JS, 1983)
"CsA had inhibitory effects on MC-26 colon cancer growth which were similar to DFMO; these effects were blocked by the addition of the polyamine, putrescine."1.27Effects of cyclosporine and alpha-difluoromethylornithine on the growth of mouse colon cancer in vitro. ( Barranco, SC; Saydjari, R; Thompson, JC; Townsend, CM, 1987)

Research

Studies (80)

TimeframeStudies, this research(%)All Research%
pre-199019 (23.75)18.7374
1990's32 (40.00)18.2507
2000's17 (21.25)29.6817
2010's12 (15.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gerner, EW13
Bruckheimer, E1
Cohen, A2
Mohammed, A2
Janakiram, NB2
Brewer, M2
Vedala, K1
Steele, VE5
Rao, CV4
Ibáñez, C1
Simó, C1
Valdés, A1
Campone, L1
Piccinelli, AL1
García-Cañas, V1
Cifuentes, A1
Renaud, S1
Corcé, V1
Cannie, I1
Ropert, M1
Lepage, S1
Loréal, O1
Deniaud, D1
Gaboriau, F1
Zell, J1
You, YN1
Boughey, JC1
Burke, CA1
Dekker, E1
Samadder, NJ1
Stoffel, E1
Bryant, T1
Zhang, Y1
Duff, A1
Biddick, L1
Singh, A1
Lightfoot, S1
McLaren, CE1
Fujikawa-Brooks, S1
Chen, WP1
Gillen, DL1
Pelot, D3
Meyskens, FL6
Telang, N1
Katdare, M1
Devita, VT1
Marshall, JR1
Uemura, T1
Stringer, DE2
Blohm-Mangone, KA2
Mackenzie, GG4
Sun, Y4
Huang, L4
Xie, G4
Ouyang, N3
Gupta, RC1
Johnson, F1
Komninou, D3
Kopelovich, L3
Rigas, B4
Zhu, C2
Qiao, G1
Vrankova, K1
Nie, T1
Alston, N1
Murray, OT1
Constantinides, PP1
Tao, L2
Kramer, PM2
Wang, W2
Yang, S1
Lubet, RA3
Pereira, MA4
Hudson, EA1
Howells, LM1
Gallacher-Horley, B1
Fox, LH1
Gescher, A1
Manson, MM1
Ignatenko, NA4
Zhang, H1
Watts, GS1
Skovan, BA1
Reddy, BS7
Li, Y1
Umar, A2
Nemoto, T1
Kubota, S1
Ishida, H1
Murata, N1
Hashimoto, D1
Lance, P2
Hurley, LH1
Goldschmid, S1
Raul, F1
Gosse, F1
Osswald, AB1
Bouhadjar, M1
Foltzer-Jourdainne, C1
Marescaux, J1
Soler, L1
Tuma, R1
Warrell, RP1
Burchenal, JH1
Kingsnorth, AN2
King, WW1
Diekema, KA1
McCann, PP1
Ross, JS2
Malt, RA2
Liu, T1
Mokuolu, AO1
Holt, PR1
Wallon, UM1
Shassetz, LR1
Cress, AE1
Bowden, GT1
Singh, J2
Kulkarni, N1
Kelloff, G4
McGarrity, TJ1
Peiffer, LP1
Smith, JP1
Kramer, ST1
Demers, LM1
Love, RR2
Carbone, PP2
Verma, AK3
Gilmore, D1
Carey, P1
Tutsch, KD2
Pomplun, M2
Wilding, G1
Löser, C1
Starp, F1
Fölsch, UR1
Emerson, S1
Durbin, T1
Doyle, K1
Lagerberg, W1
Douglas, JA1
Larson, PO1
Blair, IA1
Li, H1
Schut, HA1
Conran, P1
Hawk, EE1
Kelloff, GJ1
Reynolds, S1
Rajagopal, S1
Chakrabarty, S1
Hudmon, KS1
Chamberlain, RM1
Erdman, SH1
Powell, MB1
Holubec, H1
Guillén-Rodriguez, JM1
Viner, JL1
Hawk, ET1
Yu, D1
Seitz, PK1
Selvanayagam, P1
Rajaraman, S1
Townsend, CM7
Cooper, CW1
Lakanen, JR1
Coward, JK1
Pegg, AE1
Tsunoda, A1
Shibusawa, M1
Tsunoda, Y1
Yasuda, N1
Koike, T1
Wang, M1
Tokumo, K2
Rigotty, J2
Zang, E2
Khoury, MD1
Gamet, L1
Cazenave, Y1
Trocheris, V1
Denis-Pouxviel, C1
Murat, JC1
Zirvi, KA1
Atabek, U1
Saydjari, R6
Alexander, RW2
Upp, JR2
Barranco, SC5
Thompson, JC6
Eggstein, S1
Imdahl, A1
Kohler, M1
Waibel, M1
Farthmann, EH1
Nayini, J1
D'Agostino, L1
Pignata, S1
Daniele, B1
D'Adamo, G1
Ferraro, C1
Silvestro, G1
Tagliaferri, P1
Contegiacomo, A1
Gentile, R1
Tritto, G1
Neelam, SS1
Bernabei, A1
Freedland, C1
Thompson, R1
Corbett, TH1
Luk, GD4
Zhang, SZ2
Hamilton, SR2
Celano, P3
Baylin, SB3
Casero, RA3
Halline, AG1
Dudeja, PK1
Brasitus, TA1
Waldrop, RD1
Rubin, NH1
Rayford, PL1
Tempero, MA1
Nishioka, K2
Knott, K1
Zetterman, RK1
Umemoto, S1
Berchtold, CM1
Giardiello, FM2
Abeloff, MD1
Rosen, ST1
Zeltzman, M1
Sjoerdsma, A1
Tutton, PJ1
Barkla, DH1
Nelkin, BD1
Arundel, CM1
Tofilon, PJ1
Lamuraglia, GM1
Lacaine, F1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase III Trial of the Safety and Efficacy of Eflornithine Combined With Sulindac Compared to Eflornithine, Sulindac as Single Agents in Patients With Familial Adenomatous Polyposis[NCT01483144]Phase 3171 participants (Actual)Interventional2013-10-31Completed
Bowman Birk Inhibitor Concentrate and Oral Leukoplakia: A Randomized Phase IIb Trial[NCT00330382]Phase 2325 participants (Actual)Interventional1999-01-31Completed
TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563]Phase 270 participants (Anticipated)Interventional2023-03-14Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Improvement in Investigator Lower GI Assessment

Global assessment of change in lower GI polyp burden. These are binary outcomes derived from scores assigned by the investigator during each procedure, using a scale (-2, -1, 0, +1, +2) which corresponds, respectively, to the investigator's overall qualitative assessment of: much worse, worse, no change, improved, much improved. Summarizes the corresponding 6- and 12-month investigator change scores according to whether or not there was any positive improvement at either month 6 (compared to baseline) or at month 12 (compared to baseline or month 6), under the condition that there be no worsening at either timepoint. (NCT01483144)
Timeframe: through month 12 assessment

,,
InterventionParticipants (Count of Participants)
ImprovedNot Improved
Eflornithine Plus Sulindac2234
Eflornithine Plus Sulindac Placebo1641
Sulindac Plus Eflornithine Placebo2236

Improvement in Investigator Upper GI Assessment

Global assessment of change in upper GI polyp burden. These are binary outcomes derived from scores assigned by the investigator during each procedure, using a scale (-2, -1, 0, +1, +2) which corresponds, respectively, to the investigator's overall qualitative assessment of: much worse, worse, no change, improved, much improved. Summarizes the corresponding 6- and 12-month investigator change scores according to whether or not there was any positive improvement at either month 6 (compared to baseline) or at month 12 (compared to baseline or month 6), under the condition that there be no worsening at either timepoint. (NCT01483144)
Timeframe: through month 12 assessment

,,
InterventionParticipants (Count of Participants)
ImprovedNot Improved
Eflornithine Plus Sulindac1145
Eflornithine Plus Sulindac Placebo1047
Sulindac Plus Eflornithine Placebo1048

Number of Subjects With Any FAP-related Event.

Progression of disease by evaluation of FAP-related events over the course of study treatment (NCT01483144)
Timeframe: Up to 48 months from the start of treatment

,,
InterventionParticipants (Count of Participants)
Number with FAP-related eventsNumber with Lower GI FAP-related events
Eflornithine Plus Sulindac182
Eflornithine Plus Sulindac Placebo2310
Sulindac Plus Eflornithine Placebo229

Clinical Impression From Photographs

"A secondary clinical response measure was bsaed on blinded, comparative judgments of pairs of photographs of the same lesion at baseline and 6 months on study. Picture pairs were assigned to album page, one pair per page, at random. Five physicians experienced with evaluation of oral mucosal tissue abnormalities, but blinded to study arm and time point, independently compared the pictures in each pair using a 7-point scale. The scale ranged from, top photo shows a complete response relative to the bottom photo, through, the same degree of disease is shown by top photo and bottom photo, to bottom photo shows a complete response relative to the top photo. Raw scores were transformed to account for relative position of the earlier and later photo, and averaged across the 5 reviewers. Final scores ranged from one, denoting a CR at 6 months, to 4, which indicated no change, through 7, which indicated that the 6-month photo depicted a much worse situation than the pretreatment photo." (NCT00330382)
Timeframe: Baseline to 6 months

Interventionscore (Mean)
Arm I (Bowman-Birk Inhibitor Concentrate)4.0
Arm II (Placebo)3.6

Relative Percent Change in Buccal-Cell Neu Protein (ng/mg)

100% x (Posttreatment value - pretreatment value)/(pretreatment value) (NCT00330382)
Timeframe: Baseline to 6 months

Interventionpercentage change (Median)
Arm I (Bowman-Birk Inhibitor Concentrate)-10.1
Arm II (Placebo)-4.2

Relative Percent Change in Protease Activity (Delta RFU/Min/µg)

100% x (Posttreatment value - pretreatment value)/(pretreatment value) (NCT00330382)
Timeframe: Baseline to 6 months

Interventionpercentage change (Median)
Arm I (Bowman-Birk Inhibitor Concentrate)15.7
Arm II (Placebo)17.2

Relative Percent Change in Serum Neu Protein (ng/ml)

100% x (Posttreatment value - pretreatment value)/(pretreatment value) (NCT00330382)
Timeframe: Baseline to 6 months

Interventionpercentage change (Median)
Arm I (Bowman-Birk Inhibitor Concentrate)-3.9
Arm II (Placebo)-8.1

Relative Percent Change in Total Lesion Area After 6 Months on Study

Relative percent change in total lesion area was defined as 100 times (area posttreatment minus area pretreatment) all divided by pretreatment area. (NCT00330382)
Timeframe: 6 months

Interventionpercentage change (Mean)
Arm I (Bowman-Birk Inhibitor Concentrate)-20.6
Arm II (Placebo)-17.1

The Difference in Rated Degree of Malignancy Between Randomization and 6-month Specimen

The reviewer was blinded to study-arm assignment (drug or placebo), but not to time point of specimen. For each specimen, the reviewer marked a continuum to indicate degree of tissue abnormality. The continuum was 140 mm long, and anchored by the word 'Normal' on the left and 'Malignant' on the right. The distance from the left edge of the continuum to the reviewer's mark, in mm, was determined. For analyses, a score was formed by subtracting the pretreatment value from the 6-month value. Thus, a retreat from 'Malignancy' over time produces a negative score, a score of zero denotes no change, and a positive score denotes a worsening situation. Positive values indicate histologic worsening, whereas negative scores denote improvement over the 6-month study period. (NCT00330382)
Timeframe: Baselie to 6 months

Interventionscore (Mean)
Arm I (Bowman-Birk Inhibitor Concentrate)1.2
Arm II (Placebo)3.6

Combined Percentage Change From Baseline in Proteolytic Activity, Buccal-cell Erb-B2 (Neu) and Serum Levels of Neu at 6 Months

(NCT00330382)
Timeframe: Baseline to 6 months

Interventionpercentage change (Median)
Buccal-Cell NewProtease ActivitySerum Neu (n=41)
Combined Bowman-Birk Inhibitor Concentrate and Placebo Groups-8.916.2-4.1

Number of Participants by Category of Clinical Response at 6 Months

Category of clinical response was based on the magnitude of relative percent change in total lesion area. A complete response (CR) was declared if the relative percent change in total lesion area was minus 100 percent. A partial response (PR) was a relative percent decrease in total lesion area of 50% or more, without being a CR. Disease progression was a relative percent increase in total lesion area of at least 50%. Remaining cases were declared to be stable disease. (NCT00330382)
Timeframe: 6 months

,
Interventionparticipants (Number)
Complete response (CR)Partial response (PR)Stable diseaseDisease progression
Arm I (Bowman-Birk Inhibitor Concentrate)210274
Arm II (Placebo)212266

Number of Participants Report at Least 1 Adverse Event During the Study

The onset of adverse event is between the randomizaiton date and off-study date (NCT00330382)
Timeframe: Randomized date to Off-study date, up to 21 months

,
Interventionparticipants (Number)
Yes: report at least 1 AENo: no AE reported
Arm I (Bowman-Birk Inhibitor Concentrate)3334
Arm II (Placebo)2540

Reviews

12 reviews available for eflornithine and Colonic Neoplasms

ArticleYear
Cancer pharmacoprevention: Targeting polyamine metabolism to manage risk factors for colon cancer.
    The Journal of biological chemistry, 2018, 11-30, Volume: 293, Issue:48

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemoprevention; Colonic Neoplasms; Eflornithine;

2018
Nutrition and colon cancer prevention.
    Current opinion in clinical nutrition and metabolic care, 2009, Volume: 12, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Colonic Neoplasms; Diet;

2009
Studies with the azoxymethane-rat preclinical model for assessing colon tumor development and chemoprevention.
    Environmental and molecular mutagenesis, 2004, Volume: 44, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Chemoprevention; Colonic Neoplasms;

2004
A comprehensive strategy to combat colon cancer targeting the adenomatous polyposis coli tumor suppressor gene.
    Annals of the New York Academy of Sciences, 2005, Volume: 1059

    Topics: Adenomatous Polyposis Coli Protein; Antineoplastic Agents; Aspirin; Base Sequence; Colonic Neoplasms

2005
Rationale for, and design of, a clinical trial targeting polyamine metabolism for colon cancer chemoprevention.
    Amino acids, 2007, Volume: 33, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Che

2007
Methylglyoxal-bis(guanylhydrazone) (Methyl-GAG): current status and future prospects.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1983, Volume: 1, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemical Phenomena; Chemistry; Clinical Tri

1983
Chemoprevention of colon cancer by dietary administration of naturally-occurring and related synthetic agents.
    Advances in experimental medicine and biology, 1997, Volume: 400B

    Topics: Allyl Compounds; Anethole Trithione; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinoge

1997
Development of difluoromethylornithine (DFMO) as a chemoprevention agent.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Cell Division; Cell Trans

1999
Development of difluoromethyl-ornithine and Bowman-Birk inhibitor as chemopreventive agents by assessment of relevant biomarker modulation: some lessons learned.
    IARC scientific publications, 2001, Volume: 154

    Topics: Antineoplastic Agents; Biomarkers, Tumor; Colonic Neoplasms; Drug Evaluation; Eflornithine; Humans;

2001
The future of colon cancer prevention.
    Annals of the New York Academy of Sciences, 2001, Volume: 952

    Topics: Adenocarcinoma; Adenoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents;

2001
Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase.
    Basic life sciences, 1990, Volume: 52

    Topics: Animals; Carcinogens; Colonic Neoplasms; Eflornithine; Female; Mammary Neoplasms, Experimental; Mice

1990
Chemoprevention and chemotherapy by inhibition of ornithine decarboxylase activity and polyamine synthesis: colonic, pancreatic, mammary, and renal carcinomas.
    Advances in enzyme regulation, 1985, Volume: 24

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Division; Colonic Neoplasms; Eflornithine; Fe

1985

Trials

8 trials available for eflornithine and Colonic Neoplasms

ArticleYear
Efficacy and safety of eflornithine (CPP-1X)/sulindac combination therapy versus each as monotherapy in patients with familial adenomatous polyposis (FAP): design and rationale of a randomized, double-blind, Phase III trial.
    BMC gastroenterology, 2016, Aug-02, Volume: 16, Issue:1

    Topics: Adenomatous Polyposis Coli; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Proto

2016
Longitudinal assessment of air conduction audiograms in a phase III clinical trial of difluoromethylornithine and sulindac for prevention of sporadic colorectal adenomas.
    Cancer prevention research (Philadelphia, Pa.), 2008, Volume: 1, Issue:7

    Topics: Adenomatous Polyps; Antineoplastic Combined Chemotherapy Protocols; Audiometry, Pure-Tone; Colonic N

2008
Rationale for, and design of, a clinical trial targeting polyamine metabolism for colon cancer chemoprevention.
    Amino acids, 2007, Volume: 33, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Che

2007
Methylglyoxal-bis(guanylhydrazone) (Methyl-GAG): current status and future prospects.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1983, Volume: 1, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemical Phenomena; Chemistry; Clinical Tri

1983
Randomized phase I chemoprevention dose-seeking study of alpha-difluoromethylornithine.
    Journal of the National Cancer Institute, 1993, May-05, Volume: 85, Issue:9

    Topics: Adult; Carcinoma; Colonic Neoplasms; Eflornithine; Enzyme Induction; Female; Humans; Male; Ornithine

1993
Development of difluoromethylornithine as a chemoprevention agent for the management of colon cancer.
    Journal of cellular biochemistry. Supplement, 1995, Volume: 22

    Topics: Anticarcinogenic Agents; Cell Division; Colonic Neoplasms; Dose-Response Relationship, Drug; Eflorni

1995
Effect of alpha-difluoromethylornithine on rectal mucosal levels of polyamines in a randomized, double-blinded trial for colon cancer prevention.
    Journal of the National Cancer Institute, 1998, Aug-19, Volume: 90, Issue:16

    Topics: Adult; Aged; Aged, 80 and over; Anticarcinogenic Agents; Audiometry; Colonic Neoplasms; Double-Blind

1998
Phase I chemoprevention study of piroxicam and alpha-difluoromethylornithine.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1998, Volume: 7, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Anticarcinogenic Agents; Biopsy; Breast Neoplasms; Colonic Neoplasms

1998

Other Studies

62 other studies available for eflornithine and Colonic Neoplasms

ArticleYear
Multitargeted low-dose GLAD combination chemoprevention: a novel and promising approach to combat colon carcinogenesis.
    Neoplasia (New York, N.Y.), 2013, Volume: 15, Issue:5

    Topics: Adenomatous Polyps; Animals; Antineoplastic Combined Chemotherapy Protocols; Atorvastatin; Carcinoge

2013
Metabolomics of adherent mammalian cells by capillary electrophoresis-mass spectrometry: HT-29 cells as case study.
    Journal of pharmaceutical and biomedical analysis, 2015, Jun-10, Volume: 110

    Topics: Adenocarcinoma; Antineoplastic Agents; Cell Adhesion; Cell Proliferation; Colonic Neoplasms; Eflorni

2015
Quilamine HQ1-44, an iron chelator vectorized toward tumor cells by the polyamine transport system, inhibits HCT116 tumor growth without adverse effect.
    Biochemical pharmacology, 2015, Aug-01, Volume: 96, Issue:3

    Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Cycle; Cell Survival; Colonic Neoplasms;

2015
PACES trial: Evaluating the effectiveness of eflornithine and sulindac in preventing colon adenomas.
    Bulletin of the American College of Surgeons, 2015, Volume: 100, Issue:8

    Topics: Adenoma; Antineoplastic Agents; Clinical Trials as Topic; Colon; Colonic Neoplasms; Eflornithine; Hu

2015
Potentiating NK cell activity by combination of Rosuvastatin and Difluoromethylornithine for effective chemopreventive efficacy against Colon Cancer.
    Scientific reports, 2016, 11-14, Volume: 6

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; beta Catenin; Colonic Neoplasms; Cyclin D1; Disease

2016
Novel cell culture model for prevention of carcinogenic risk in familial adenomatous polyposis syndrome.
    Oncology reports, 2009, Volume: 21, Issue:4

    Topics: Adenomatous Polyposis Coli; Animals; Anticarcinogenic Agents; Catechin; Cell Line; Colonic Neoplasms

2009
Off-label use of approved drugs.
    Nature reviews. Clinical oncology, 2009, Volume: 6, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colonic Neoplasms; Drug Ap

2009
Polyamine transport is mediated by both endocytic and solute carrier transport mechanisms in the gastrointestinal tract.
    American journal of physiology. Gastrointestinal and liver physiology, 2010, Volume: 299, Issue:2

    Topics: Animals; Biological Transport; Catalysis; Caveolae; Caveolin 1; Cell Line, Tumor; Colonic Neoplasms;

2010
Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice.
    Gastroenterology, 2010, Volume: 139, Issue:4

    Topics: Acetyltransferases; Animals; Antineoplastic Agents; Biogenic Polyamines; Cell Line, Tumor; Colonic N

2010
Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect.
    Carcinogenesis, 2010, Volume: 31, Issue:11

    Topics: Acetyltransferases; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumo

2010
Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice.
    Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:7

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Prol

2011
The metabolism and pharmacokinetics of phospho-sulindac (OXT-328) and the effect of difluoromethylornithine.
    British journal of pharmacology, 2012, Volume: 165, Issue:7

    Topics: Animals; Cell Line, Tumor; Colonic Neoplasms; Cytosol; Eflornithine; Female; Humans; In Vitro Techni

2012
Altered expression of c-myc, p16 and p27 in rat colon tumors and its reversal by short-term treatment with chemopreventive agents.
    Carcinogenesis, 2002, Volume: 23, Issue:9

    Topics: Animals; Antineoplastic Agents; Calcium Chloride; Cell Cycle Proteins; Chemoprevention; Colonic Neop

2002
Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line.
    BMC cancer, 2003, Jan-14, Volume: 3

    Topics: Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Biological Transport; Cell Cycle; Cell Di

2003
The chemopreventive agent alpha-difluoromethylornithine blocks Ki-ras-dependent tumor formation and specific gene expression in Caco-2 cells.
    Molecular carcinogenesis, 2004, Volume: 39, Issue:4

    Topics: Animals; Antineoplastic Agents; Caco-2 Cells; Cell Communication; Cell Movement; Colonic Neoplasms;

2004
Modulation by celecoxib and difluoromethylornithine of the methylation of DNA and the estrogen receptor-alpha gene in rat colon tumors.
    Carcinogenesis, 2004, Volume: 25, Issue:10

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azoxymethane; Biomarkers, Tumor; Carcinogen

2004
Ornithine decarboxylase, mitogen-activated protein kinase and matrix metalloproteinase-2 expressions in human colon tumors.
    World journal of gastroenterology, 2005, May-28, Volume: 11, Issue:20

    Topics: Antineoplastic Agents; Colonic Neoplasms; Eflornithine; Humans; Matrix Metalloproteinase 2; Mitogen-

2005
Impact of dietary amino acids and polyamines on intestinal carcinogenesis and chemoprevention in mouse models.
    Biochemical Society transactions, 2007, Volume: 35, Issue:Pt 2

    Topics: Amino Acids; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Colonic Neoplasms; Diet; Disea

2007
Follow-up of tumor development in the colons of living rats and implications for chemoprevention trials: assessment of aspirin-difluoromethylornithine combination.
    International journal of oncology, 2007, Volume: 31, Issue:1

    Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspi

2007
Drugs to prevent colon cancer show promise, but hurdles remain for chemoprevention.
    Journal of the National Cancer Institute, 2008, Jun-04, Volume: 100, Issue:11

    Topics: Adenoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Prot

2008
Inhibition of ornithine decarboxylase with 2-difluoromethylornithine: reduced incidence of dimethylhydrazine-induced colon tumors in mice.
    Cancer research, 1983, Volume: 43, Issue:6

    Topics: 1,2-Dimethylhydrazine; Animals; Carboxy-Lyases; Carcinogens; Cell Survival; Colonic Neoplasms; Dimet

1983
Regional chemoprevention of carcinogen-induced tumors in rat colon.
    Gastroenterology, 1995, Volume: 109, Issue:4

    Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Colonic Neoplasms; Eflornithine; Ellagic Acid; Male;

1995
Polyamine-dependent expression of the matrix metalloproteinase matrilysin in a human colon cancer-derived cell line.
    Molecular carcinogenesis, 1994, Volume: 11, Issue:3

    Topics: Adenocarcinoma; Antibody Specificity; Biogenic Polyamines; Blotting, Western; Cell Division; Colonic

1994
Modulation of azoxymethane-induced mutational activation of ras protooncogenes by chemopreventive agents in colon carcinogenesis.
    Carcinogenesis, 1994, Volume: 15, Issue:7

    Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Base Sequence; Colon; Colonic Neoplasms; Eflornithin

1994
Selenium and difluoromethylornithine additively inhibit DMH-induced distal colon tumor formation in rats fed a fiber-free diet.
    Carcinogenesis, 1993, Volume: 14, Issue:11

    Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; Colonic Neoplasms; Diet; Dietary Fiber; Dimethyl

1993
Effects of gastrin and difluoromethylornithine on growth of human colon cancer.
    Digestive diseases and sciences, 1993, Volume: 38, Issue:3

    Topics: Animals; Colonic Neoplasms; Eflornithine; Humans; In Vitro Techniques; Mice; Mice, Nude; Neoplasm Tr

1993
Intermediate biomarkers of colon cancer: modulation of expression of ras oncogene by chemopreventive agents during azoxymethane induced colon carcinogenesis.
    Carcinogenesis, 1993, Volume: 14, Issue:4

    Topics: Affinity Labels; Animals; Azoxymethane; Biomarkers, Tumor; Blotting, Western; Colonic Neoplasms; Efl

1993
Dissimilar activation patterns of the carcinogen dimethylhydrazine (DMH) on intracellular polyamine metabolism in various organs.
    Zeitschrift fur Gastroenterologie, 1996, Volume: 34, Issue:12

    Topics: 1,2-Dimethylhydrazine; Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Carcinogens; C

1996
Growth arrest- and polyamine-dependent expression of spermidine/spermine N1-acetyltransferase in human tumor cells.
    Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1996, Volume: 7, Issue:4

    Topics: Acetyltransferases; Blotting, Northern; Cell Division; Colonic Neoplasms; Dactinomycin; Eflornithine

1996
Prevention by aspirin and its combination with alpha-difluoromethylornithine of azoxymethane-induced tumors, aberrant crypt foci and prostaglandin E2 levels in rat colon.
    Carcinogenesis, 1999, Volume: 20, Issue:3

    Topics: Animals; Aspirin; Azoxymethane; Colon; Colonic Neoplasms; Dinoprostone; Dose-Response Relationship,

1999
Differentiation-inducing effect of retinoic acid, difluoromethylornithine, sodium butyrate and sodium suramin in human colon cancer cells.
    Cancer letters, 1998, Dec-11, Volume: 134, Issue:1

    Topics: Antineoplastic Agents; Butyrates; Carcinoembryonic Antigen; Cell Differentiation; Cell Division; Col

1998
Perceived benefits of and barriers to participation in a phase I/II colon cancer chemoprevention trial.
    Journal of cancer education : the official journal of the American Association for Cancer Education, 1999,Summer, Volume: 14, Issue:2

    Topics: Adult; Aged; Anticarcinogenic Agents; Chemoprevention; Clinical Trials as Topic; Clinical Trials, Ph

1999
APC-dependent changes in expression of genes influencing polyamine metabolism, and consequences for gastrointestinal carcinogenesis, in the Min mouse.
    Carcinogenesis, 1999, Volume: 20, Issue:9

    Topics: Acetyltransferases; Animals; Anticarcinogenic Agents; Colon; Colonic Neoplasms; Eflornithine; Gene E

1999
Effects of vasoactive intestinal peptide on adenosine 3',5'-monophosphate, ornithine decarboxylase, and cell growth in a human colon cell line.
    Endocrinology, 1992, Volume: 131, Issue:3

    Topics: Adenocarcinoma; Blotting, Northern; Cell Division; Cell Line; Colonic Neoplasms; Cyclic AMP; Dose-Re

1992
alpha-Methyl polyamines: metabolically stable spermidine and spermine mimics capable of supporting growth in cells depleted of polyamines.
    Journal of medicinal chemistry, 1992, Feb-21, Volume: 35, Issue:4

    Topics: Animals; Cell Division; Cell Line, Transformed; Colonic Neoplasms; Eflornithine; Humans; Leukemia L1

1992
Reduced growth rate of dimethylhydrazine-induced colon tumors in rats.
    Cancer research, 1992, Feb-01, Volume: 52, Issue:3

    Topics: Animals; Body Weight; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Eflornithine; Male; Mito

1992
[Inhibition by polyamine biosynthesis inhibitor DFMO of the growth of transplanted human colon cancer in nude mice].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 1991, Volume: 13, Issue:5

    Topics: Animals; Bone Marrow; Cecal Neoplasms; Colonic Neoplasms; Eflornithine; Humans; Mice; Mice, Inbred B

1991
Chemoprevention of colon carcinogenesis by dietary administration of piroxicam, alpha-difluoromethylornithine, 16 alpha-fluoro-5-androsten-17-one, and ellagic acid individually and in combination.
    Cancer research, 1991, Sep-01, Volume: 51, Issue:17

    Topics: Animals; Body Weight; Colonic Neoplasms; Dehydroepiandrosterone; Drug Combinations; Drug Evaluation,

1991
Prevention by chemopreventive agents of azoxymethane-induced foci of aberrant crypts in rat colon.
    Cancer letters, 1991, Dec-09, Volume: 61, Issue:1

    Topics: Acetylcysteine; Allyl Compounds; Animals; Anticarcinogenic Agents; Azoxymethane; Colon; Colonic Neop

1991
Involvement of ornithine decarboxylase in the control of proliferation of the HT29 human colon cancer cell line. Effect of vasoactive intestinal peptide on enzyme activity.
    International journal of cancer, 1991, Feb-20, Volume: 47, Issue:4

    Topics: Cell Division; Colonic Neoplasms; Cyclic AMP; Eflornithine; Fetal Blood; Humans; Ornithine Decarboxy

1991
In vitro response of a human colon tumor xenograft and a lung adenocarcinoma cell line to alpha-difluoromethylornithine alone and in combination with 5-fluorouracil and doxorubicin.
    Journal of surgical oncology, 1991, Volume: 48, Issue:1

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Colonic Neoplasms; Do

1991
Differential sensitivity of various human tumors to inhibition of polyamine biosynthesis in vivo.
    International journal of cancer, 1991, Jan-02, Volume: 47, Issue:1

    Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Eflornithine; Humans; Mice; Mice, Inbred BALB

1991
Influence of gastrin, gastrin receptor blockers, epidermal growth factor, and difluoromethylornithine on the growth and the activity of ornithine decarboxylase of colonic carcinoma cells.
    Journal of cancer research and clinical oncology, 1991, Volume: 117, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Benzamides; Cell Division; Colonic Neoplasms; Eflornithine; Epidermal Gr

1991
Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal antiinflammatory drug with D,L-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor, in diet.
    Cancer research, 1990, May-01, Volume: 50, Issue:9

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Colonic Neopla

1990
Polyamine uptake by human colon carcinoma cell line CaCo-2.
    Digestion, 1990, Volume: 46 Suppl 2

    Topics: Biogenic Polyamines; Cell Line; Colonic Neoplasms; Eflornithine; Humans; Ornithine Decarboxylase; Or

1990
Combination of flavone acetic acid (FAA) with adriamycin, cis-platinum and difluoromethylornithine (DFMO) in vitro against human colon cancer cells.
    Investigational new drugs, 1990, Volume: 8, Issue:3

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cisplatin; Col

1990
Effects of timing of administration and dose of difluoromethylornithine on rat colonic carcinogenesis.
    Journal of the National Cancer Institute, 1989, Mar-15, Volume: 81, Issue:6

    Topics: Animals; Azoxymethane; Colon; Colonic Neoplasms; Eflornithine; Enzyme Induction; Intestinal Mucosa;

1989
Polyamines differentially modulate the transcription of growth-associated genes in human colon carcinoma cells.
    The Journal of biological chemistry, 1989, May-25, Volume: 264, Issue:15

    Topics: Actins; Cell Division; Cell Line; Colonic Neoplasms; Eflornithine; Genes; Histones; Humans; Ornithin

1989
1,2-Dimethylhydrazine-induced alterations in N1-acetylspermidine levels in rat distal colonic mucosa: effects of 2-difluoromethylornithine.
    Biochimica et biophysica acta, 1989, Jul-21, Volume: 992, Issue:1

    Topics: 1,2-Dimethylhydrazine; Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Chromatography

1989
Photoperiod influences the growth of colon cancer in mice.
    Life sciences, 1989, Volume: 45, Issue:8

    Topics: Adenocarcinoma; Animals; Body Weight; Circadian Rhythm; Colonic Neoplasms; Eflornithine; Light; Male

1989
Chemoprevention of mouse colon tumors with difluoromethylornithine during and after carcinogen treatment.
    Cancer research, 1989, Nov-01, Volume: 49, Issue:21

    Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; Eflornithine; Erythrocytes; Male; Mice; Polyamines;

1989
2-Deoxy-D-glucose inhibits the antitumor effects of alpha-difluoromethylornithine on the growth of colon cancer in vivo.
    Investigational new drugs, 1989, Volume: 7, Issue:2-3

    Topics: Animals; Biogenic Polyamines; Cell Survival; Colonic Neoplasms; Deoxy Sugars; Deoxyglucose; DNA, Neo

1989
[Antitumor effect of alpha-difluoromethylornithine (DFMO) changes in ornithine decarboxylase (ODC) activity and polyamine (PA) levels in human tumor transplanted into nude mice].
    Nihon Geka Gakkai zasshi, 1989, Volume: 90, Issue:5

    Topics: Animals; Biogenic Polyamines; Breast Neoplasms; Colonic Neoplasms; Drug Screening Assays, Antitumor;

1989
Modulation of growth gene expression by selective alteration of polyamines in human colon carcinoma cells.
    Biochemical and biophysical research communications, 1989, Nov-30, Volume: 165, Issue:1

    Topics: Adenosine; Blotting, Northern; Cell Division; Cell Line; Colonic Neoplasms; Eflornithine; Gene Expre

1989
Phase II trials of alpha-difluoromethylornithine, an inhibitor of polyamine synthesis, in advanced small cell lung cancer and colon cancer.
    Cancer treatment reports, 1986, Volume: 70, Issue:7

    Topics: Aged; Antineoplastic Agents; Carcinoma, Small Cell; Colonic Neoplasms; Drug Evaluation; Eflornithine

1986
Comparison of the effects of an ornithine decarboxylase inhibitor on the intestinal epithelium and on intestinal tumors.
    Cancer research, 1986, Volume: 46, Issue:12 Pt 1

    Topics: Animals; Cell Division; Colonic Neoplasms; Eflornithine; Epithelium; Female; Intestines; Male; Mice;

1986
Effects of cyclosporine and alpha-difluoromethylornithine on the growth of mouse colon cancer in vitro.
    Life sciences, 1987, Jan-26, Volume: 40, Issue:4

    Topics: Adenocarcinoma; Animals; Cell Division; Colonic Neoplasms; Cyclosporins; Eflornithine; In Vitro Tech

1987
Cyclosporine and alpha-difluoromethylornithine exhibit differential effects on colon and pancreatic cancer in vitro.
    Investigational new drugs, 1987, Volume: 5, Issue:3

    Topics: Animals; Colonic Neoplasms; Cyclosporins; Dose-Response Relationship, Drug; Eflornithine; Humans; Mi

1987
Effect of polyamine depletion on c-myc expression in human colon carcinoma cells.
    The Journal of biological chemistry, 1988, Apr-25, Volume: 263, Issue:12

    Topics: Actins; Cell Cycle; Cell Division; Colonic Neoplasms; Dactinomycin; Eflornithine; Gene Expression Re

1988
Effects of alpha-difluoromethylornithine-induced polyamine depletion on the radiosensitivity of a human colon carcinoma cell line.
    Radiation research, 1988, Volume: 114, Issue:3

    Topics: Cell Line; Cell Survival; Cesium Radioisotopes; Colonic Neoplasms; Eflornithine; Gamma Rays; Humans;

1988
Alpha-difluoromethylornithine-induced inhibition of growth of autochthonous experimental colonic tumors produced by azoxymethane in male F344 rats.
    Cancer research, 1988, Nov-15, Volume: 48, Issue:22

    Topics: Animals; Azoxymethane; Colonic Neoplasms; Eflornithine; Male; Ornithine Decarboxylase; Rats; Rats, I

1988
Differential sensitivity of pancreatic and colon cancer to cyclosporine and alpha-difluoromethylornithine in vivo.
    Investigational new drugs, 1988, Volume: 6, Issue:4

    Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Cricetinae; Cyclosporins; Eflornithine; Mesocricetus; Mi

1988