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eflornithine and Chronic Illness

eflornithine has been researched along with Chronic Illness in 4 studies

Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.

Research Excerpts

ExcerptRelevanceReference
"This study was designed to determine the efficacy of L-arginine in healing of gastric ulcers induced by acetic acid and to assess the role of nitric oxide (NO), prostaglandins, gastrin and polyamines in the healing process."7.69Healing of chronic gastric ulcerations by L-arginine. Role of nitric oxide, prostaglandins, gastrin and polyamines. ( Brzozowski, T; Dembiński, A; Drozdowicz, D; Konturek, SJ; Stachura, J, 1995)
"In a single-blind, placebo-controlled, cross-over study in 11 patients with chronic non-suppurative, culture-negative prostatitis, alpha-difluoromethylornithine (alpha DFMO) (18 g/day) was administered orally for 1 month."7.66alpha-Difluoromethylornithine (alpha DFMO) and phenoxybenzamine hydrochloride in the treatment of chronic non-suppurative prostatitis. ( Dunzendorfer, U, 1981)
"This study was designed to determine the efficacy of L-arginine in healing of gastric ulcers induced by acetic acid and to assess the role of nitric oxide (NO), prostaglandins, gastrin and polyamines in the healing process."3.69Healing of chronic gastric ulcerations by L-arginine. Role of nitric oxide, prostaglandins, gastrin and polyamines. ( Brzozowski, T; Dembiński, A; Drozdowicz, D; Konturek, SJ; Stachura, J, 1995)
"DL-alpha-Difluoromethylornithine (DFMO), a specific enzyme-activated irreversible inhibitor of ornithine decarboxylase (ODC) was previously shown to cure mice infected with Trypanosoma brucei brucei, a parasite of game and cattle in Africa and Trypanosoma brucei rhodesiense, a human African Sleeping Sickness pathogen."3.66Further studies on difluoromethylornithine in African trypanosomes. ( Amole, BO; Bacchi, CJ; Clarkson, AB; Hutner, SH; McCann, PP; Nathan, HC; Seed, JR; Sjoerdsma, A, 1981)
"In a single-blind, placebo-controlled, cross-over study in 11 patients with chronic non-suppurative, culture-negative prostatitis, alpha-difluoromethylornithine (alpha DFMO) (18 g/day) was administered orally for 1 month."3.66alpha-Difluoromethylornithine (alpha DFMO) and phenoxybenzamine hydrochloride in the treatment of chronic non-suppurative prostatitis. ( Dunzendorfer, U, 1981)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19902 (50.00)18.7374
1990's2 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
McCann, PP1
Bacchi, CJ1
Clarkson, AB1
Seed, JR1
Nathan, HC1
Amole, BO1
Hutner, SH1
Sjoerdsma, A1
Dunzendorfer, U1
Konturek, SJ2
Brzozowski, T2
Majka, I1
Pawlik, W1
Stachura, J2
Drozdowicz, D1
Dembiński, A1

Other Studies

4 other studies available for eflornithine and Chronic Illness

ArticleYear
Further studies on difluoromethylornithine in African trypanosomes.
    Medical biology, 1981, Volume: 59, Issue:5-6

    Topics: Acute Disease; Animals; Arvicolinae; Bleomycin; Carboxy-Lyases; Central Nervous System Diseases; Chr

1981
alpha-Difluoromethylornithine (alpha DFMO) and phenoxybenzamine hydrochloride in the treatment of chronic non-suppurative prostatitis.
    Arzneimittel-Forschung, 1981, Volume: 31, Issue:2

    Topics: Adult; Blood Cell Count; Chronic Disease; Drug Therapy, Combination; Eflornithine; Humans; Male; Mid

1981
Omentum and basic fibroblast growth factor in healing of chronic gastric ulcerations in rats.
    Digestive diseases and sciences, 1994, Volume: 39, Issue:5

    Topics: Animals; Blood Flow Velocity; Chronic Disease; Dinoprostone; Eflornithine; Fibroblast Growth Factor

1994
Healing of chronic gastric ulcerations by L-arginine. Role of nitric oxide, prostaglandins, gastrin and polyamines.
    Digestion, 1995, Volume: 56, Issue:6

    Topics: Animals; Arginine; Chronic Disease; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Efl

1995