eflornithine has been researched along with Chronic Disease in 4 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was designed to determine the efficacy of L-arginine in healing of gastric ulcers induced by acetic acid and to assess the role of nitric oxide (NO), prostaglandins, gastrin and polyamines in the healing process." | 7.69 | Healing of chronic gastric ulcerations by L-arginine. Role of nitric oxide, prostaglandins, gastrin and polyamines. ( Brzozowski, T; Dembiński, A; Drozdowicz, D; Konturek, SJ; Stachura, J, 1995) |
| "In a single-blind, placebo-controlled, cross-over study in 11 patients with chronic non-suppurative, culture-negative prostatitis, alpha-difluoromethylornithine (alpha DFMO) (18 g/day) was administered orally for 1 month." | 7.66 | alpha-Difluoromethylornithine (alpha DFMO) and phenoxybenzamine hydrochloride in the treatment of chronic non-suppurative prostatitis. ( Dunzendorfer, U, 1981) |
| "This study was designed to determine the efficacy of L-arginine in healing of gastric ulcers induced by acetic acid and to assess the role of nitric oxide (NO), prostaglandins, gastrin and polyamines in the healing process." | 3.69 | Healing of chronic gastric ulcerations by L-arginine. Role of nitric oxide, prostaglandins, gastrin and polyamines. ( Brzozowski, T; Dembiński, A; Drozdowicz, D; Konturek, SJ; Stachura, J, 1995) |
| "DL-alpha-Difluoromethylornithine (DFMO), a specific enzyme-activated irreversible inhibitor of ornithine decarboxylase (ODC) was previously shown to cure mice infected with Trypanosoma brucei brucei, a parasite of game and cattle in Africa and Trypanosoma brucei rhodesiense, a human African Sleeping Sickness pathogen." | 3.66 | Further studies on difluoromethylornithine in African trypanosomes. ( Amole, BO; Bacchi, CJ; Clarkson, AB; Hutner, SH; McCann, PP; Nathan, HC; Seed, JR; Sjoerdsma, A, 1981) |
| "In a single-blind, placebo-controlled, cross-over study in 11 patients with chronic non-suppurative, culture-negative prostatitis, alpha-difluoromethylornithine (alpha DFMO) (18 g/day) was administered orally for 1 month." | 3.66 | alpha-Difluoromethylornithine (alpha DFMO) and phenoxybenzamine hydrochloride in the treatment of chronic non-suppurative prostatitis. ( Dunzendorfer, U, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McCann, PP | 1 |
| Bacchi, CJ | 1 |
| Clarkson, AB | 1 |
| Seed, JR | 1 |
| Nathan, HC | 1 |
| Amole, BO | 1 |
| Hutner, SH | 1 |
| Sjoerdsma, A | 1 |
| Dunzendorfer, U | 1 |
| Konturek, SJ | 2 |
| Brzozowski, T | 2 |
| Majka, I | 1 |
| Pawlik, W | 1 |
| Stachura, J | 2 |
| Drozdowicz, D | 1 |
| Dembiński, A | 1 |
4 other studies available for eflornithine and Chronic Disease
| Article | Year |
|---|---|
Further studies on difluoromethylornithine in African trypanosomes.
Topics: Acute Disease; Animals; Arvicolinae; Bleomycin; Carboxy-Lyases; Central Nervous System Diseases; Chr | 1981 |
alpha-Difluoromethylornithine (alpha DFMO) and phenoxybenzamine hydrochloride in the treatment of chronic non-suppurative prostatitis.
Topics: Adult; Blood Cell Count; Chronic Disease; Drug Therapy, Combination; Eflornithine; Humans; Male; Mid | 1981 |
Omentum and basic fibroblast growth factor in healing of chronic gastric ulcerations in rats.
Topics: Animals; Blood Flow Velocity; Chronic Disease; Dinoprostone; Eflornithine; Fibroblast Growth Factor | 1994 |
Healing of chronic gastric ulcerations by L-arginine. Role of nitric oxide, prostaglandins, gastrin and polyamines.
Topics: Animals; Arginine; Chronic Disease; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Efl | 1995 |